INT109618

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Context Info
Confidence 0.42
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.31
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

3a4 (Mus musculus)
Pain Link Frequency Relevance Heat
Bioavailability 1 98.50 Very High Very High Very High
Paracetamol 14 96.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 2 90.48 High High
Necrosis 1 79.96 Quite High
Hepatotoxicity 1 63.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Grapefruit juice increases bioavailability of a number of drugs because of inhibition of the P-glycoprotein pump and inhibition of intestinal cytochrome P450 3A4 enzyme.
Negative_regulation (inhibition) of 3A4 associated with bioavailability
1) Confidence 0.42 Published 2008 Journal J Med Food Section Abstract Doc Link 19053875 Disease Relevance 0 Pain Relevance 0.65
On the other hand, in mice treated with PP (10 and 25 mg/kg, p.o.), the activities of P4501A2, 2B1, 3A4 and 2E1 were dramatically inhibited, and the activity of PST was significantly enhanced.
Negative_regulation (inhibited) of 3A4
2) Confidence 0.41 Published 2003 Journal Phytother Res Section Abstract Doc Link 12672155 Disease Relevance 0.31 Pain Relevance 0.13

General Comments

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