INT109633

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Context Info
Confidence 0.15
First Reported 2003
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 2.29
Pain Relevance 6.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (TP53INP2)
Anatomy Link Frequency
spinal cord 2
TP53INP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 25 100.00 Very High Very High Very High
Ultiva 18 99.74 Very High Very High Very High
Endogenous opioid 3 99.44 Very High Very High Very High
Enkephalin 33 98.20 Very High Very High Very High
Opioid 7 97.96 Very High Very High Very High
Perioperative pain 4 97.16 Very High Very High Very High
Spinal cord 6 96.36 Very High Very High Very High
Hyperalgesia 2 95.20 Very High Very High Very High
allodynia 4 94.36 High High
agonist 11 94.12 High High
Disease Link Frequency Relevance Heat
Nociception 10 98.04 Very High Very High Very High
Post Operative Pain 4 97.16 Very High Very High Very High
Charcot Marie Tooth Disease 1 95.68 Very High Very High Very High
Hyperalgesia 4 95.20 Very High Very High Very High
Neuropathic Pain 4 94.36 High High
Neuroblastoma 2 93.60 High High
Pain 4 89.72 High High
Herpes Simplex Virus 2 79.16 Quite High
Intraoperative Complications 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we examined the role of hDOR internalization and down-regulation in this differential desensitization.
Negative_regulation (down-regulation) of hDOR
1) Confidence 0.15 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12672796 Disease Relevance 0.19 Pain Relevance 0.54
The study suggests that down-regulation of DOR contributes to remifentanil and surgery-induced nociception, and that postoperative pain is completely reversed by increasing enkephalin levels in the spinal cord and the periphery.
Negative_regulation (regulation) of DOR in spinal cord associated with nociception, enkephalin, perioperative pain, ultiva and spinal cord
2) Confidence 0.06 Published 2009 Journal Pain Section Abstract Doc Link 19058913 Disease Relevance 1.05 Pain Relevance 1.71
Both remifentanil and surgery decreased DOR mRNA levels (up to days 2 and 4, respectively) in the dorsal root ganglia, but not in the spinal cord.
Negative_regulation (decreased) of DOR in spinal cord associated with ultiva and spinal cord
3) Confidence 0.06 Published 2009 Journal Pain Section Abstract Doc Link 19058913 Disease Relevance 0.97 Pain Relevance 1.71
In the present study, we examined desensitization of the human delta-opioid receptor (hDOR) produced by endogenous opioid peptides Leu-enkephalin (Tyr-Gly-Gly-Phe-Leu) and Met-enkephalin (Tyr-Gly-Gly-Phe-Met), and the contribution of internalization in this process.
Spec (examined) Negative_regulation (desensitization) of hDOR associated with endogenous opioid, enkephalin and opioid receptor
4) Confidence 0.03 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15102931 Disease Relevance 0 Pain Relevance 0.76
In conclusion, hDOR desensitization depends both on its internalization and its sorting either to the recycling pathway or to lysosomes.
Negative_regulation (desensitization) of hDOR
5) Confidence 0.02 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15102931 Disease Relevance 0 Pain Relevance 0.51
SNC-80 also caused a marked hDOR down-regulation by 30% as observed by Western blot.
Negative_regulation (down-regulation) of hDOR
6) Confidence 0.02 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15102931 Disease Relevance 0 Pain Relevance 0.93
While in functional experiments, we were not able to observe a major effect in non-sorted SK-N-BE cells expressing beta-arrestin1-GFP, the enrichment by 18-fold with FACS resulted in a robust increase of beta-arrestin1-GFP expression associated with strong hDOR desensitization.
Negative_regulation (desensitization) of hDOR
7) Confidence 0.00 Published 2006 Journal Brain Res. Section Abstract Doc Link 16938287 Disease Relevance 0.07 Pain Relevance 0.31

General Comments

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