INT109643

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Context Info
Confidence 0.78
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (HCRT) cytoplasm (HCRT)
Anatomy Link Frequency
lateral 1
somatotropes 1
HCRT (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 7 99.40 Very High Very High Very High
Locus ceruleus 2 97.86 Very High Very High Very High
Thalamus 2 81.80 Quite High
agonist 7 65.44 Quite High
conotoxin 1 65.08 Quite High
tetrodotoxin 1 54.52 Quite High
antagonist 3 53.68 Quite High
midbrain 1 43.60 Quite Low
Neuropeptide 2 36.48 Quite Low
nMDA receptor 12 7.52 Low Low
Disease Link Frequency Relevance Heat
Sleep Disorders 2 48.48 Quite Low
Encephalitis 1 39.08 Quite Low
Targeted Disruption 8 5.00 Very Low Very Low Very Low
Unconsciousness 4 5.00 Very Low Very Low Very Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Amnesia 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Ganglion Cysts 1 5.00 Very Low Very Low Very Low
Depression 1 5.00 Very Low Very Low Very Low
Hepatotoxicity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The descending sleep pathway includes projections from the ventro-lateral pre-optic nucleus and the lateral hypothalamic orexinogenic neurons to the TMN, raphé, locus coeruleus and pedunculo-pontine and latero-dorsal tegmental nuclei; in addition, lateral hypothalamic neurons which release orexin also innervate the cerebral cortices and the basal forebrain.
Localization (release) of orexin in lateral associated with locus ceruleus
1) Confidence 0.78 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989583 Disease Relevance 0 Pain Relevance 0.19
We conclude that orexin-B increases the L-type Ca(2+) current and GH secretion through orexin receptors and PKC-mediated signalling pathways in ovine somatotropes.
Localization (secretion) of orexin in somatotropes associated with kinase c
2) Confidence 0.73 Published 2003 Journal Neuroendocrinology Section Abstract Doc Link 12673048 Disease Relevance 0 Pain Relevance 0.35

General Comments

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