INT109649

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Context Info
Confidence 0.37
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.51
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Cldn1) plasma membrane (Cldn1)
Cldn1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 27 90.48 High High
anesthesia 2 25.00 Low Low
cytokine 8 11.80 Low Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
member 8 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Inflammatory stimuli 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Muscular Dystrophy 3 96.48 Very High Very High Very High
INFLAMMATION 30 90.48 High High
Alopecia 3 89.12 High High
Targeted Disruption 15 76.48 Quite High
Aging 4 30.32 Quite Low
Coronary Artery Disease 6 27.32 Quite Low
Injury 4 25.00 Low Low
Congenital Anomalies 10 5.00 Very Low Very Low Very Low
Acanthosis 8 5.00 Very Low Very Low Very Low
Psoriasis 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The following primers were used for identification: Cldn1 (sense 5?
Gene_expression (sense) of Cldn1
1) Confidence 0.37 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2575783 Disease Relevance 0 Pain Relevance 0
To this purpose, we used two tight junction markers, the Zonula occludens (ZO-1) and claudin-1 proteins, and a glial marker, the aquaporin-4 (AQP4) protein, whose expression is correlated with BBB differentiation and integrity.
Gene_expression (expression) of claudin-1
2) Confidence 0.27 Published 2003 Journal Glia Section Abstract Doc Link 12673830 Disease Relevance 0.19 Pain Relevance 0
Western blot analysis of epidermal lysates confirmed the down-regulation of claudin 3 and occludin at the protein level and also revealed reduced claudin-1 expression in K5-R1/R2 mice (Fig. 8 C).
Gene_expression (expression) of claudin-1
3) Confidence 0.13 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.31 Pain Relevance 0.05

General Comments

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