INT109650

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Context Info
Confidence 0.78
First Reported 2003
Last Reported 2011
Negated 4
Speculated 4
Reported most in Body
Documents 87
Total Number 109
Disease Relevance 51.52
Pain Relevance 20.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Aqp4) plasma membrane (Aqp4) protein complex (Aqp4)
transmembrane transport (Aqp4) cytoplasm (Aqp4)
Anatomy Link Frequency
astrocytes 15
T cell 13
brain 12
spinal cords 6
microglial cells 5
Aqp4 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 527 100.00 Very High Very High Very High
Spinal cord 497 99.96 Very High Very High Very High
addiction 59 99.92 Very High Very High Very High
Neuropathic pain 114 99.68 Very High Very High Very High
Peripheral nervous system 282 99.60 Very High Very High Very High
tolerance 47 99.32 Very High Very High Very High
Inflammation 466 98.94 Very High Very High Very High
fluoxetine 24 98.76 Very High Very High Very High
Hippocampus 87 98.04 Very High Very High Very High
analgesia 32 97.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 327 100.00 Very High Very High Very High
Immunization 144 100.00 Very High Very High Very High
Autism 160 99.92 Very High Very High Very High
Disorder Of Lipid Metabolism 1 99.92 Very High Very High Very High
Cerebral Edema 160 99.80 Very High Very High Very High
Disease 482 99.68 Very High Very High Very High
Neuropathic Pain 184 99.68 Very High Very High Very High
Pressure And Volume Under Development 470 99.62 Very High Very High Very High
Anaplastic Astrocytoma 27 99.60 Very High Very High Very High
Neuromyelitis Optica 719 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Aquaporin 4 (AQP4) is most strongly expressed in astrocytes throughout central nervous system, and plays an important role in some pathophysiological processes in brain.
Gene_expression (expressed) of AQP4 in brain associated with central nervous system
1) Confidence 0.78 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18973795 Disease Relevance 0.14 Pain Relevance 1.17
Aquaporin 4 (AQP4) is most strongly expressed in astrocytes throughout central nervous system, and plays an important role in some pathophysiological processes in brain.
Gene_expression (expressed) of Aquaporin 4 in brain associated with central nervous system
2) Confidence 0.78 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18973795 Disease Relevance 0.14 Pain Relevance 1.17
Notably, CMS procedure significantly increased the hippocampal AQP4 expression, which was reversed by 4-week fluoxetine treatment.
Gene_expression (expression) of AQP4 associated with stress and fluoxetine
3) Confidence 0.78 Published 2009 Journal Neuropsychopharmacology Section Abstract Doc Link 18923397 Disease Relevance 1.23 Pain Relevance 0.71
Aquaporin-4 (AQP4), a key molecule for maintaining water homeostasis in the central nervous system, is expressed in adult neural stem cells (ANSCs) as well as astrocytes.
Gene_expression (expressed) of AQP4 in astrocytes associated with central nervous system
4) Confidence 0.78 Published 2009 Journal Neuropsychopharmacology Section Abstract Doc Link 18923397 Disease Relevance 0.85 Pain Relevance 0.27
Aquaporin-4 (AQP4), a key molecule for maintaining water homeostasis in the central nervous system, is expressed in adult neural stem cells (ANSCs) as well as astrocytes.
Gene_expression (expressed) of Aquaporin-4 in astrocytes associated with central nervous system
5) Confidence 0.78 Published 2009 Journal Neuropsychopharmacology Section Abstract Doc Link 18923397 Disease Relevance 0.85 Pain Relevance 0.27
Altered expression of aquaporin 4, apolipoprotein D, and prostaglandin synthase is indicative of modified LH physiology.
Gene_expression (expression) of aquaporin 4 associated with disorder of lipid metabolism
6) Confidence 0.75 Published 2008 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 18591478 Disease Relevance 0.27 Pain Relevance 0.54
METHODS: We used confocal microscopy and flow cytometry to evaluate the selectivity and immunopathological consequences of Ig binding to surface epitopes of living target cells expressing aquaporin-4 fused at its cytoplasmic N-terminus with GFP.
Gene_expression (expressing) of aquaporin-4
7) Confidence 0.73 Published 2007 Journal Neurology Section Body Doc Link 17928579 Disease Relevance 0 Pain Relevance 0
Paranodal astrocytic endfeet highly express aquaporin-4.
Gene_expression (express) of aquaporin-4
8) Confidence 0.73 Published 2007 Journal Neurology Section Body Doc Link 17928579 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: NMO patients' serum IgG has a selective pathologic effect on cell membranes expressing aquaporin-4.
Gene_expression (expressing) of aquaporin-4
9) Confidence 0.73 Published 2007 Journal Neurology Section Body Doc Link 17928579 Disease Relevance 0 Pain Relevance 0
To this purpose, we used two tight junction markers, the Zonula occludens (ZO-1) and claudin-1 proteins, and a glial marker, the aquaporin-4 (AQP4) protein, whose expression is correlated with BBB differentiation and integrity.
Gene_expression (expression) of aquaporin-4
10) Confidence 0.72 Published 2003 Journal Glia Section Abstract Doc Link 12673830 Disease Relevance 0.19 Pain Relevance 0
For exemple, AQP4 over-expression in human astrocytomas correlates with the presence of brain edema on magnetic resonance scans [80].
Gene_expression (over) of AQP4 in brain associated with anaplastic astrocytoma and cerebral edema
11) Confidence 0.70 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 1.18 Pain Relevance 0.13
AQP4 is abundantly expressed in the basolateral membrane of the ependyma and glia limitans lining subependymal layer and pia.
Gene_expression (expressed) of AQP4
12) Confidence 0.70 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 0.62 Pain Relevance 0
Decreased AQP4 expression may mean that cell structure, cell volume and ionic homeostatis are compromised.
Gene_expression (expression) of AQP4
13) Confidence 0.70 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 0.73 Pain Relevance 0
The highly polarized expression of AQP4 suggests it may be involved in maintaining the structural and functional integrity of the ependyma.
Gene_expression (expression) of AQP4
14) Confidence 0.70 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 0.48 Pain Relevance 0
Moreover a recent study demonstrated the expression of AQP4 mRNA and protein within reactive microglial cells in vivo [95].
Gene_expression (expression) of AQP4 in microglial cells
15) Confidence 0.70 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 0.11 Pain Relevance 0.26
In addition to GFAP, altered expression of AQP4 has been associated with this neurologic disease; in particular AQP4 expression was decreased in cerebellum of subjects with autism.
Gene_expression (expression) of AQP4 in cerebellum associated with autism and disease
16) Confidence 0.70 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 0.85 Pain Relevance 0.03
Although AQP4 expression is polarized in astrocytes foot processes adjacent to endothelial cells, in the absence of endothelia (e.g. cultured astrocytes and malignant astrocytes) [78, 80, 105] AQP4 redistributes throughout the astrocyte cell membrane, suggesting that endothelial cells signal astrocytes to polarize AQP4 expression in the cell membrane [93].
Gene_expression (expression) of AQP4 in astrocytes associated with malignant neoplastic disease
17) Confidence 0.70 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 0.45 Pain Relevance 0.11
Correlations between AQP4 expression and brain edema have been reported after brain ischaemia [17, 50], and traumatic brain injury in rodents [17, 91].
Gene_expression (expression) of AQP4 in brain associated with brain hemorrhage, cerebral edema and brain injury
18) Confidence 0.70 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 1.36 Pain Relevance 0.15
It is possible that all cells expressing AQP4 expression within microglial cells may represent a molecular adaptation to maintain ion water homeostasis in the injured brain.
Gene_expression (expression) of AQP4 in microglial cells
19) Confidence 0.70 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 0.09 Pain Relevance 0
Nevertheless, additional studies are necessary to determine whether altered AQP4 expression represents a protective and/or maladaptive response to CNS inflammation.
Gene_expression (expression) of AQP4 associated with inflammation and central nervous system
20) Confidence 0.70 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 1.35 Pain Relevance 0.16

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