INT109651

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Context Info
Confidence 0.53
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 23
Total Number 24
Disease Relevance 8.50
Pain Relevance 10.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Aqp4) plasma membrane (Aqp4) protein complex (Aqp4)
transmembrane transport (Aqp4) cytoplasm (Aqp4)
Anatomy Link Frequency
glial cells 1
retina 1
spinal cord 1
ependymal cells 1
brain 1
Aqp4 (Mus musculus)
Pain Link Frequency Relevance Heat
potassium channel 29 99.86 Very High Very High Very High
opioid receptor 54 99.84 Very High Very High Very High
Kinase C 2 99.56 Very High Very High Very High
Morphine 66 99.48 Very High Very High Very High
analgesia 20 99.12 Very High Very High Very High
Neurotransmitter 22 98.84 Very High Very High Very High
Dorsal horn 12 98.84 Very High Very High Very High
Physical dependence 14 98.44 Very High Very High Very High
Spinal cord 60 98.12 Very High Very High Very High
tolerance 26 98.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 128 100.00 Very High Very High Very High
Targeted Disruption 51 100.00 Very High Very High Very High
Cerebral Edema 16 100.00 Very High Very High Very High
Brain Hemorrhage 5 100.00 Very High Very High Very High
Drug Dependence 18 98.44 Very High Very High Very High
Retina Disease 100 97.26 Very High Very High Very High
Apoptosis 167 97.04 Very High Very High Very High
Stress 155 96.96 Very High Very High Very High
Hydrocephalus 4 94.36 High High
Disease 41 87.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This may be responsible for the mislocation of Kir4.1 and the downregulation of AQP4, ?
Negative_regulation (downregulation) of AQP4
1) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.32 Pain Relevance 0
This observation was confirmed by immunoblot analysis of AQP4 expression, revealing a significant decrease of the AQP4 expression level by 30% as compared to the controls (Fig. 2A,B).
Negative_regulation (decrease) of AQP4
2) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.32 Pain Relevance 0
In the present study, effects of AQP4 deficiency on opioid receptor characteristics were investigated by [(3)H]-diprenorphine binding assays.
Negative_regulation (deficiency) of AQP4 associated with opioid receptor
3) Confidence 0.43 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19429174 Disease Relevance 0.10 Pain Relevance 0.75
Our previous study indicated that aquaporin4 (AQP4) deficiency potentiated morphine analgesia, but attenuated tolerance and physical dependence induced by chronic exposure to morphine.
Negative_regulation (deficiency) of AQP4 associated with physical dependence, tolerance, analgesia and morphine
4) Confidence 0.43 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19429174 Disease Relevance 0.10 Pain Relevance 0.61
Effects of aquaporin4 deficiency on opioid receptors characteristics in naive and chronic morphine-treated mice.
Negative_regulation (deficiency) of aquaporin4 associated with opioid receptor and morphine
5) Confidence 0.43 Published 2009 Journal Neurosci. Lett. Section Title Doc Link 19429174 Disease Relevance 0.15 Pain Relevance 0.85
Taken together, at the first time, we found that AQP4 deficiency decreased the affinity and increased the density of opioid receptors.
Negative_regulation (deficiency) of AQP4 associated with opioid receptor
6) Confidence 0.43 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19429174 Disease Relevance 0.15 Pain Relevance 0.92
Additionally, AQP4 deficiency did not affect chronic morphine-induced alterations of opioid receptor characteristics.
Negative_regulation (deficiency) of AQP4 associated with opioid receptor and morphine
7) Confidence 0.43 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19429174 Disease Relevance 0.14 Pain Relevance 0.90
Our previous study indicated that aquaporin4 (AQP4) deficiency potentiated morphine analgesia, but attenuated tolerance and physical dependence induced by chronic exposure to morphine.
Negative_regulation (deficiency) of aquaporin4 associated with physical dependence, tolerance, analgesia and morphine
8) Confidence 0.43 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19429174 Disease Relevance 0.10 Pain Relevance 0.61
This suggested that AQP4 deficiency inhibited the development of morphine physical dependence. (4) Repeated morphine administration down-regulated cerebral glutamate transporter 1 (GLT-1) expression in wild-type mice.
Negative_regulation (deficiency) of AQP4 associated with glutamate, physical dependence and morphine
9) Confidence 0.43 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18973795 Disease Relevance 0.59 Pain Relevance 2.16
Taken together, these results demonstrated that AQP4 deficiency potentiated morphine analgesia, attenuated morphine tolerance and physical dependence.
Negative_regulation (deficiency) of AQP4 associated with physical dependence, tolerance, analgesia and morphine
10) Confidence 0.43 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18973795 Disease Relevance 0.57 Pain Relevance 1.90
Although it is unlikely that RNAi could be used as an efficient drug to rapidly block astrocytes swelling, AQP4 inhibition studies by RNAi in animals will be very useful to test the hypothesis that the inhibition of AQP4 activity is a potential target for the treatment of brain edema.
Negative_regulation (inhibition) of AQP4 in astrocytes associated with pressure and volume under development
11) Confidence 0.40 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923373 Disease Relevance 0.73 Pain Relevance 0.04
Moreover, animal models imply a protective effect of AQP4 by facilitating excess fluid assembled in the brain parenchyma after BBB disruption [69, 70].
Negative_regulation (effect) of AQP4 in parenchyma
12) Confidence 0.39 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 1.70 Pain Relevance 0.04
Here we show that experimental detachment of mouse retina induces mislocation of the inwardly rectifying potassium channels (Kir4.1) and a downregulation of the water channel protein (AQP4) in Müller cells.
Negative_regulation (downregulation) of AQP4 in retina associated with potassium channel
13) Confidence 0.39 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2754330 Disease Relevance 0.30 Pain Relevance 0.08
Using an experimental mouse model of retinal detachment, we (i) confirm morpho-functional alterations in reactive Müller glial cells including a mislocation of Kir4.1 potassium channels and a downregulation of AQP4 water channels, accompanied by disturbed volume regulation of the cells; (ii) show a fast and strong decrease of the dystrophin protein, Dp71; and finally (iii) demonstrate an impaired BRB function as evidenced by increased retinal vascular permeability.
Negative_regulation (downregulation) of AQP4 in glial cells associated with potassium channel and retina disease
14) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.20 Pain Relevance 0.08
AQP4 is also expressed in ependymal cells, but is absent from neurons, oligodendrocytes, and microglia [32].
Negative_regulation (absent) of AQP4 in ependymal cells
15) Confidence 0.37 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 0.52 Pain Relevance 0.65
AQP4 deficiency influences K+-stimulated releases of striatal neurotransmitters [9].
Negative_regulation (deficiency) of AQP4 associated with neurotransmitter
16) Confidence 0.37 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 0.30 Pain Relevance 0.88
Western blot showed a 60% reduction in the ZO-1 protein content in mdx mice and a similar reduction in AQP4 content compared with the control brain.
Negative_regulation (reduction) of AQP4 in brain
17) Confidence 0.35 Published 2003 Journal Glia Section Abstract Doc Link 12673830 Disease Relevance 0.15 Pain Relevance 0
Compared to normal mice, AQP4 knock-out mice exhibit reduced brain edema and neurologic improvement following ischemic brain injury [46, 99]; in these animals the rate of osmotic swelling is significantly reduced in the deeper lamina of the dorsal horn of the spinal cord [86].
Negative_regulation (reduced) of AQP4 in spinal cord associated with brain hemorrhage, targeted disruption, pressure and volume under development, dorsal horn, cerebral edema and spinal cord
18) Confidence 0.34 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 1.06 Pain Relevance 0.15
Furthermore, it has been reported that the water permeability of AQP4 is reduced following protein kinase C activation [34] and that AQP1 could be gated by cyclic GMP [6, 13].
Negative_regulation (reduced) of AQP4 associated with kinase c
19) Confidence 0.29 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923373 Disease Relevance 0 Pain Relevance 0.05
The downregulation of AQP4 gene was also observed in microarray studies (Table 1).
Negative_regulation (downregulation) of AQP4 gene
20) Confidence 0.28 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.59 Pain Relevance 0

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