INT109652

Context Info Confidence 0.32 First Reported 2003 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 0.92 Pain Relevance 0.07

Golgi apparatus (Tjp1) plasma membrane (Tjp1) nucleus (Tjp1) cytoplasm (Tjp1)

Anatomy Link Frequency brain 1 Tjp1 (Mus musculus)

Pain Link Frequency Relevance Heat Crohn's disease 4 91.40 Inflammation 11 25.00 anesthesia 2 25.00 cytokine 2 5.00 Versed 2 5.00 spastic colon 1 5.00 tetrodotoxin 1 5.00

Disease Link Frequency Relevance Heat Colitis 31 97.90 Disease 4 91.40 Weight Loss 2 88.00 Muscular Dystrophy 3 76.84 Inflammatory Bowel Disease 17 66.84 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super 2 50.00 INFLAMMATION 10 25.00 Injury 2 25.00 Diarrhoea 8 5.00 Body Weight 7 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Western blot showed a 60% reduction in the ZO-1 protein content in mdx mice and a similar reduction in AQP4 content compared with the control brain.

Negative_regulation (reduction) of ZO-1 protein in brain

1) Confidence 0.32 Published 2003 Journal Glia Section Abstract Doc Link 12673830 Disease Relevance 0.15 Pain Relevance 0

In mice, colonic exposure to supernatants from IBS-D patients resulted in a rapid increase in the phosphorylation of myosin light chain and delayed redistribution of ZO-1 in colonocytes.

Negative_regulation (redistribution) of ZO-1

2) Confidence 0.31 Published 2008 Journal Gut Section Body Doc Link 18194983 Disease Relevance 0 Pain Relevance 0

Moreover, using a mouse colitis model, Resta-Lenert et al. have shown that the increase in intestinal permeability is associated with a decrease of occludin and ZO-1 phosphorylation [54].

Negative_regulation (decrease) of ZO-1 associated with colitis

3) Confidence 0.30 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2110898 Disease Relevance 0.77 Pain Relevance 0.07

General Comments

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