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Context Info
Confidence 0.32
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.92
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Tjp1) plasma membrane (Tjp1) nucleus (Tjp1)
cytoplasm (Tjp1)
Anatomy Link Frequency
brain 1
Tjp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Crohn's disease 4 91.40 High High
Inflammation 11 25.00 Low Low
anesthesia 2 25.00 Low Low
cytokine 2 5.00 Very Low Very Low Very Low
Versed 2 5.00 Very Low Very Low Very Low
spastic colon 1 5.00 Very Low Very Low Very Low
tetrodotoxin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colitis 31 97.90 Very High Very High Very High
Disease 4 91.40 High High
Weight Loss 2 88.00 High High
Muscular Dystrophy 3 76.84 Quite High
Inflammatory Bowel Disease 17 66.84 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

2 50.00 Quite Low
INFLAMMATION 10 25.00 Low Low
Injury 2 25.00 Low Low
Diarrhoea 8 5.00 Very Low Very Low Very Low
Body Weight 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blot showed a 60% reduction in the ZO-1 protein content in mdx mice and a similar reduction in AQP4 content compared with the control brain.
Negative_regulation (reduction) of ZO-1 protein in brain
1) Confidence 0.32 Published 2003 Journal Glia Section Abstract Doc Link 12673830 Disease Relevance 0.15 Pain Relevance 0
In mice, colonic exposure to supernatants from IBS-D patients resulted in a rapid increase in the phosphorylation of myosin light chain and delayed redistribution of ZO-1 in colonocytes.
Negative_regulation (redistribution) of ZO-1
2) Confidence 0.31 Published 2008 Journal Gut Section Body Doc Link 18194983 Disease Relevance 0 Pain Relevance 0
Moreover, using a mouse colitis model, Resta-Lenert et al. have shown that the increase in intestinal permeability is associated with a decrease of occludin and ZO-1 phosphorylation [54].
Negative_regulation (decrease) of ZO-1 associated with colitis
3) Confidence 0.30 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2110898 Disease Relevance 0.77 Pain Relevance 0.07

General Comments

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