INT109655

Context Info Confidence 0.08 First Reported 2001 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 11 Total Number 15 Disease Relevance 7.90 Pain Relevance 2.41

mitochondrion (TFAM) nucleus (TFAM) DNA binding (TFAM)

TFAM (Homo sapiens)

Pain Link Frequency Relevance Heat Multiple sclerosis 260 99.12 Nerve growth factor 5 98.24 Osteoarthritis 412 95.52 Pain 9 83.64 cytokine 82 66.72 metalloproteinase 24 56.16 Inflammation 138 54.08 qutenza 1 50.96 Inflammatory response 33 50.24 rheumatoid arthritis 24 45.36

Disease Link Frequency Relevance Heat Multiple Sclerosis 276 99.12 Peripheral Arterial Disease 108 98.68 Diabetes Mellitus 58 97.96 Osteoarthritis 416 95.52 Cardiovascular Disease 70 89.12 Cold Sores 4 89.04 Aging 22 88.76 Disease 356 88.44 Atherosclerosis 78 87.44 Anaemia 1 85.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

If a group of genes shares the same cis-regulatory motif, then the transcription factor that binds to the motif may regulate the group of genes.

transcription factor Binding (binds) of

1) Confidence 0.08 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 0.80 Pain Relevance 0

-induced DNA binding activity of the transcription factor RUNX-2 we used a sandwich ELISA assay kit.

transcription factor Binding (binding) of

2) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.63 Pain Relevance 0.32

Of the 89 motifs, 36 matched to 26 known transcription factor binding sites (TFBS) in JASPAR [50] with a matching score ?

transcription factor Binding (binding) of

3) Confidence 0.06 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 0.49 Pain Relevance 0

Onto-Express analyses depicted in Figure 4 shows that transcription factor binding is a highly significant component in our microarray data.

transcription factor Binding (binding) of

4) Confidence 0.05 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2227948 Disease Relevance 0.39 Pain Relevance 0.19

-induced DNA binding activity of the transcription factor RUNX-2 we used a sandwich ELISA assay kit.

transcription factor Binding (activity) of

5) Confidence 0.05 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.63 Pain Relevance 0.32

-MAPK isoform and the activation and DNA binding activity of the transcription factor RUNX-2.

transcription factor Binding (activity) of

6) Confidence 0.05 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.64 Pain Relevance 0.34

-MAPK isoform and the activation and DNA binding activity of the transcription factor RUNX-2.

transcription factor Binding (binding) of

7) Confidence 0.05 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.69 Pain Relevance 0.36

We found that TCF2 and CDC5L bind very similar promoter motifs and seem to control overlapping sets of up and down regulated genes in this study.

TCF2 Binding (bind) of

8) Confidence 0.04 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2227948 Disease Relevance 0.24 Pain Relevance 0.08

Our regulatory network was constructed by integrating transcription factor binding site information (from TRANSFAC) with gene expression data using graph TFs (Bioconductor functions for transcription network analysis).

transcription factor Binding (integrating) of

9) Confidence 0.04 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2227948 Disease Relevance 0.21 Pain Relevance 0.07

Another transcription factor that we found in our transcription analysis, CDC5L, was downregulated.

transcription factor Binding (found) of

10) Confidence 0.04 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2227948 Disease Relevance 1.18 Pain Relevance 0.31

It also suppresses Luman, another cellular transcription factor that binds HCF.

transcription factor Binding (binds) of

11) Confidence 0.04 Published 2008 Journal J. Neurovirol. Section Abstract Doc Link 19016376 Disease Relevance 0.34 Pain Relevance 0.22

Molecular mechanisms involving changes in chromatin structure and/or transcription factor binding have been demonstrated for gamma gene induction by butyrate.

transcription factor Binding (binding) of

12) Confidence 0.03 Published 2001 Journal Pediatr Pathol Mol Med Section Abstract Doc Link 12673846 Disease Relevance 0.25 Pain Relevance 0.08

In these cells, the inhibition of p38 MAPK affects the activity of the IL-10 promoter by inhibiting binding of the transcription factor Sp1 [81].

transcription factor Binding (binding) of

13) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.05 Pain Relevance 0.09

This transcription factor binds as a homodimer to the cAMP-responsive element and induces transcription of genes in response to hormonal stimulation [25].

transcription factor Binding (binds) of

14) Confidence 0.01 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2529314 Disease Relevance 0.71 Pain Relevance 0

Through the Fisher Exact test, binding sites of transcription factor AP-1 and CREB appeared to be significantly enriched (q-value < 0.05).

transcription factor Spec (appeared) Binding (binding) of

15) Confidence 0.01 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2529314 Disease Relevance 0.66 Pain Relevance 0.03

General Comments

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