INT109658

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Context Info
Confidence 0.67
First Reported 2003
Last Reported 2009
Negated 0
Speculated 1
Reported most in Title
Documents 3
Total Number 4
Disease Relevance 1.80
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL1RAPL1) plasma membrane (IL1RAPL1) intracellular (IL1RAPL1)
cytoplasm (IL1RAPL1)
Anatomy Link Frequency
chondrocytes 1
immune cells 1
temporomandibular joints 1
IL1RAPL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 22 100.00 Very High Very High Very High
antagonist 12 100.00 Very High Very High Very High
Snapping jaw 2 98.48 Very High Very High Very High
Inflammation 35 93.56 High High
Inflammatory response 2 88.32 High High
Bioavailability 1 72.52 Quite High
Central nervous system 2 51.68 Quite High
Etanercept 7 5.00 Very Low Very Low Very Low
rheumatoid arthritis 6 5.00 Very Low Very Low Very Low
Infliximab 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Temporomandibular Joint Syndrome 2 98.48 Very High Very High Very High
Necrosis 1 98.32 Very High Very High Very High
Cancer 2 97.96 Very High Very High Very High
INFLAMMATION 36 93.56 High High
Disease 63 93.04 High High
Infection 2 88.04 High High
Sprains And Strains 29 64.76 Quite High
Mouth Ulcer 5 54.64 Quite High
Inflammatory Bowel Disease 22 44.24 Quite Low
Uveitis 7 43.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: The purpose of this study was to investigate methods and expression of the recombinant human interleukin-1 receptor antagonist gene transfected into chondrocytes of temporomandibular joints (TMJ).
Spec (investigate) Gene_expression (expression) of interleukin-1 receptor in temporomandibular joints associated with antagonist
1) Confidence 0.67 Published 2003 Journal Hua Xi Kou Qiang Yi Xue Za Zhi Section Abstract Doc Link 12674613 Disease Relevance 0.07 Pain Relevance 0.16
[An experimental study on gene transfection of human interleukin-1 receptor antagonist gene into chondrocytes of temporomandibular joint].
Gene_expression (transfection) of interleukin-1 receptor in chondrocytes associated with snapping jaw and antagonist
2) Confidence 0.67 Published 2003 Journal Hua Xi Kou Qiang Yi Xue Za Zhi Section Title Doc Link 12674613 Disease Relevance 0.10 Pain Relevance 0.19
, which in turn leads to production of other proinflammatory cytokines like interleukin-1 (IL-1) and IL-6 by other immune cells.
Gene_expression (production) of interleukin-1 in immune cells associated with cytokine
3) Confidence 0.06 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697543 Disease Relevance 1.12 Pain Relevance 0.20
In vivo mucosal delivery of bioactive human interleukin 1 receptor antagonist produced by Streptococcus gordonii

Background

Gene_expression (produced) of interleukin 1 receptor associated with antagonist
4) Confidence 0.04 Published 2003 Journal BMC Biotechnol Section Title Doc Link PMC222906 Disease Relevance 0.50 Pain Relevance 0.31

General Comments

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