INT109688

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Context Info
Confidence 0.47
First Reported 2003
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.01
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TNNT1)
Anatomy Link Frequency
blood 2
plaques 1
chest 1
band 1
autonomic 1
TNNT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Percutaneous transluminal coronary angioplasty 8 98.44 Very High Very High Very High
Angina 26 97.20 Very High Very High Very High
ischemia 6 93.72 High High
Catecholamine 141 67.72 Quite High
cytokine 18 63.84 Quite High
Dopamine 12 54.20 Quite High
Central nervous system 6 53.76 Quite High
Inflammation 11 21.76 Low Low
Inflammatory response 5 12.72 Low Low
Kinase C 3 10.28 Low Low
Disease Link Frequency Relevance Heat
Acute Coronary Syndrome 39 99.80 Very High Very High Very High
Necrosis 28 98.98 Very High Very High Very High
Myocardial Infarction 38 98.28 Very High Very High Very High
Angina 15 97.20 Very High Very High Very High
Diabetes Mellitus 2 95.48 Very High Very High Very High
Injury 4 94.96 High High
Atherosclerosis 14 94.48 High High
Coronary Artery Disease 10 94.16 High High
Disease 14 90.40 High High
Anaerobic Bacterial Infections 153 85.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A significant univariate association with time to peak concentration of serum troponin T was identified for primary stenting (p < 0.0005), time from onset of chest pain to intervention (p < 0.04), and diabetes mellitus (p < 0.01).
troponin T Binding (association) of in chest associated with angina and diabetes mellitus
1) Confidence 0.47 Published 2003 Journal Angiology Section Abstract Doc Link 12678195 Disease Relevance 0.57 Pain Relevance 0.62
The use of human heart-type fatty acid-binding protein as an early diagnostic biochemical marker of myocardial necrosis in patients with acute coronary syndrome, and its comparison with troponin-T and creatine kinase-myocardial band.
troponin-T Binding (comparison) of in band associated with acute coronary syndrome and necrosis
2) Confidence 0.36 Published 2006 Journal Heart Vessels Section Title Doc Link 17151819 Disease Relevance 0.85 Pain Relevance 0.34
However, we observed an inverse association of troponin T and systolic pressure, a positive association with diastolic pressure and mean blood pressure variations, suggesting that pressure instability contributed to elevation of troponin T in these patients.
troponin T Binding (association) of in blood
3) Confidence 0.36 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1434771 Disease Relevance 0.86 Pain Relevance 0.09
However, we observed an inverse association of troponin T and systolic pressure, a positive association with diastolic pressure and mean blood pressure variations, suggesting that pressure instability contributed to elevation of troponin T in these patients.
troponin T Binding (association) of in blood
4) Confidence 0.36 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1434771 Disease Relevance 0.84 Pain Relevance 0.09
Troponin T was inversely associated with systolic pressure (r = -0.53, p = 0.01) during autonomic instability period.
Troponin T Binding (associated) of in autonomic
5) Confidence 0.35 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1434771 Disease Relevance 0.07 Pain Relevance 0.03
Recently, a substudy from GUSTO-IV clearly demonstrated that TnT is associated with early and late risk of mortality and myocardial infarction, probably due to greater microembolization risk or to major extension of coronary atherosclerosis.8 Hence, the persistence of increased risk over time may reflect more severe disease with greater likelihood of continued coronary plaques instability.
TnT Binding (associated) of in plaques associated with atherosclerosis, disease and myocardial infarction
6) Confidence 0.29 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 0.83 Pain Relevance 0.08

General Comments

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