INT109699

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Context Info
Confidence 0.43
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 2.21
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (BMP2) growth (BMP2) extracellular region (BMP2)
embryo development (BMP2) protein complex (BMP2) cell-cell signaling (BMP2)
Anatomy Link Frequency
cartilage 1
femur 1
crest 1
BMP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 8 98.44 Very High Very High Very High
Osteoarthritis 26 84.16 Quite High
cytokine 25 69.40 Quite High
Pain 20 68.96 Quite High
imagery 2 29.96 Quite Low
rheumatoid arthritis 2 5.68 Low Low
psoriasis 3 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
visual analogue scale 2 5.00 Very Low Very Low Very Low
drug abuse 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fracture Healing 64 99.84 Very High Very High Very High
INFLAMMATION 10 98.44 Very High Very High Very High
Injury 42 92.28 High High
Malignant Neoplastic Disease 12 90.16 High High
Cancer 26 88.64 High High
Osteophyte 2 88.32 High High
Aging 4 85.12 High High
Osteoarthritis 26 84.16 Quite High
Pressure Volume 2 Under Development 9 84.08 Quite High
Shock 1 82.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further studies [29] have added a partial catabolic effect on cartilage ECM indicating a regulative role for BMP-2 in ECM maintenance, especially during inflammatory induced turnover.
Regulation (regulative) of BMP-2 in cartilage associated with inflammation
1) Confidence 0.43 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2920860 Disease Relevance 0.41 Pain Relevance 0.16
The down-regulation of Cox-2 and BMP-2 was also in concordance with NHEK data.
Regulation (regulation) of BMP-2
2) Confidence 0.38 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.19 Pain Relevance 0
Of these patients, 277 had their cages implanted with rhBMP-2 on an absorbable collagen sponge and 402 received autograft transferred from the iliac crest.
Regulation (cages) of rhBMP-2 in crest
3) Confidence 0.36 Published 2003 Journal J Spinal Disord Tech Section Abstract Doc Link 12679664 Disease Relevance 0.08 Pain Relevance 0.07
To the best of our knowledge only ID1, ID2 and ID3 have been identified as most significantly up-regulated early targets of the osteogenic BMP2, BMP6 and BMP8 [46].
Regulation (targets) of BMP2
4) Confidence 0.35 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0.29 Pain Relevance 0
Einhorn et al (2003) used a femur fracture model in 144 rats to determine the effects of a single percutaneous injection of rhBMP-2 on fracture healing.
Spec (determine) Regulation (effects) of rhBMP-2 in femur associated with fracture healing
5) Confidence 0.34 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721393 Disease Relevance 0.29 Pain Relevance 0
The concentrations of BMP-2 and BMP-7 were determined by ELISA.
Regulation (concentrations) of BMP-2
6) Confidence 0.26 Published 2010 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2920860 Disease Relevance 0 Pain Relevance 0
In a prospective randomized, controlled study, Jones et al (2004a, b) studied the efficacy of rhBMP-2 (INFUSE bone graft; Medtronic Sofamor Danek, Memphis, TN, USA) on an absorbable collagen sponge combined with freeze-dried cancellous autograft for grafting of diaphyseal tibial defects.
Regulation (efficacy) of rhBMP-2
7) Confidence 0.20 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721393 Disease Relevance 0.93 Pain Relevance 0

General Comments

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