INT109714

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Context Info
Confidence 0.72
First Reported 2003
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 7
Total Number 10
Disease Relevance 3.80
Pain Relevance 6.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SLC6A4) endosome (SLC6A4) plasma membrane (SLC6A4)
Anatomy Link Frequency
gut 3
JAR 2
Caco-2 2
lymphoblast 1
T cells 1
SLC6A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 64 100.00 Very High Very High Very High
fluoxetine 15 96.56 Very High Very High Very High
spastic colon 24 96.08 Very High Very High Very High
sSRI 17 96.08 Very High Very High Very High
Desipramine 8 91.76 High High
depression 25 86.12 High High
Nicotine 102 84.04 Quite High
addiction 21 79.60 Quite High
cocaine 2 63.48 Quite High
Potency 4 62.04 Quite High
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

18 96.08 Very High Very High Very High
Reprotox - General 1 3 94.28 High High
Stress 6 91.68 High High
Depression 25 86.12 High High
Functional Bowel Disorder 6 83.92 Quite High
Nicotine Addiction 195 82.08 Quite High
Congenital Anomalies 3 76.28 Quite High
Substance Withdrawal Syndrome 3 42.72 Quite Low
Heart Disease 3 5.00 Very Low Very Low Very Low
Premenstrual Syndrome 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent molecular studies have raised critical questions about multiple SERT mRNA transcripts in the human gut, the role of polymorphic SERT promoter in the regulation of enteric SERT expression and the ability of 5-HTTLPR to affect human SERT gene transcription.
Transcription (transcripts) of SERT in gut
1) Confidence 0.72 Published 2008 Journal Trends Mol Med Section Abstract Doc Link 18550438 Disease Relevance 0.24 Pain Relevance 1.01
Recent molecular studies have raised critical questions about multiple SERT mRNA transcripts in the human gut, the role of polymorphic SERT promoter in the regulation of enteric SERT expression and the ability of 5-HTTLPR to affect human SERT gene transcription.
Transcription (transcription) of SERT in gut
2) Confidence 0.72 Published 2008 Journal Trends Mol Med Section Abstract Doc Link 18550438 Disease Relevance 0.22 Pain Relevance 0.97
Functionality studies of the 5-HTT gene transcription of 5-HTTLPR have shown that the short variant is associated with lower expression of 5-HTT and lower 5-HT reuptake activity in lymphoblasts and placental choriocarcinoma (JAR) cells (8,9).
Transcription (transcription) of 5-HTT in JAR associated with reprotox - general 1
3) Confidence 0.72 Published 2009 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2852756 Disease Relevance 0.64 Pain Relevance 0.12
Functionality studies of the 5-HTT gene transcription of 5-HTTLPR have shown that the short variant is associated with lower expression of 5-HTT and lower 5-HT reuptake activity in lymphoblasts and placental choriocarcinoma (JAR) cells (8,9).
Transcription (transcription) of 5-HTTLPR in JAR associated with reprotox - general 1
4) Confidence 0.63 Published 2009 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2852756 Disease Relevance 0.64 Pain Relevance 0.12
Recent studies have shown that 5-HTTLPR polymorphisms have significant effects on 5-HTT mRNA expression in lymphoblast cell lines and that the average methylation was higher among short alleles with trends for linearity with heterozygotes as an intermediate (41,42).
Transcription (expression) of 5-HTT in lymphoblast
5) Confidence 0.63 Published 2009 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2852756 Disease Relevance 0.20 Pain Relevance 0.20
Recent molecular studies have raised critical questions about multiple SERT mRNA transcripts in the human gut, the role of polymorphic SERT promoter in the regulation of enteric SERT expression and the ability of 5-HTTLPR to affect human SERT gene transcription.
Transcription (transcripts) of SERT in gut
6) Confidence 0.60 Published 2008 Journal Trends Mol Med Section Abstract Doc Link 18550438 Disease Relevance 0.23 Pain Relevance 1.01
Reverse transcriptase-polymerase chain reaction indicates that mRNA of the neuronal serotonin transporter (SERT) is present in Caco-2 cells and in human small intestine.
Transcription (present) of SERT in Caco-2 associated with serotonin
7) Confidence 0.53 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12682218 Disease Relevance 0 Pain Relevance 0.94
Reverse transcriptase-polymerase chain reaction indicates that mRNA of the neuronal serotonin transporter (SERT) is present in Caco-2 cells and in human small intestine.
Transcription (present) of serotonin transporter in Caco-2 associated with serotonin
8) Confidence 0.53 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12682218 Disease Relevance 0 Pain Relevance 0.95
The levels of MAPK phosphorylation, 5-HTT mRNA expression and 5-HT uptake all increased in the IFN-alpha-treated cells but were blocked in those that were pretreated with MAPK inhibitors and fluoxetine.
Transcription (expression) of 5-HTT associated with fluoxetine
9) Confidence 0.52 Published 2008 Journal J. Psychopharmacol. (Oxford) Section Abstract Doc Link 18308792 Disease Relevance 0.16 Pain Relevance 0.46
By performing Western blotting, real-time reverse transcriptase-polymerase chain reaction and [3H]5-HT labelling, we examined MAPK phosphorylation, 5-HTT mRNA expression and 5-HT uptake in Jurkat T cells.
Spec (examined) Transcription (expression) of 5-HTT in T cells
10) Confidence 0.52 Published 2008 Journal J. Psychopharmacol. (Oxford) Section Abstract Doc Link 18308792 Disease Relevance 0.14 Pain Relevance 0.41

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