INT109724

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Context Info
Confidence 0.07
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 3.15
Pain Relevance 8.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (FSCN1) cell motility (FSCN1) protein binding, bridging (FSCN1)
cytoplasm (FSCN1)
Anatomy Link Frequency
spinal cord 2
spinal nerve 1
spinal 1
FSCN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal nerve ligature 154 100.00 Very High Very High Very High
nMDA receptor 12 100.00 Very High Very High Very High
Brush evoked pain 4 100.00 Very High Very High Very High
ketamine 188 99.92 Very High Very High Very High
intrathecal 65 99.48 Very High Very High Very High
Etanercept 6 99.40 Very High Very High Very High
Spinal cord 21 99.06 Very High Very High Very High
Neuropathic pain 111 98.96 Very High Very High Very High
allodynia 77 96.96 Very High Very High Very High
Pain 13 93.80 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 192 100.00 Very High Very High Very High
Pain 17 93.80 High High
Necrosis 4 75.00 Quite High
Cancer 4 75.00 Quite High
Nervous System Injury 8 5.00 Very Low Very Low Very Low
Sleep Disorders 6 5.00 Very Low Very Low Very Low
Nociception 6 5.00 Very Low Very Low Very Low
Vomiting 4 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Xerostomia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In separate experiments using Western blots and immunohistochemistry, ipsilateral lumbar spinal cord and L5 and L6 DRG were analyzed for total and phosphorylated p38 after SNL alone or SNL combined with etanercept pretreatment.
Phosphorylation (phosphorylated) of SNL in spinal cord associated with spinal nerve ligature, etanercept and spinal cord
1) Confidence 0.07 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12684435 Disease Relevance 0.68 Pain Relevance 1.77
In separate experiments using Western blots and immunohistochemistry, ipsilateral lumbar spinal cord and L5 and L6 DRG were analyzed for total and phosphorylated p38 after SNL alone or SNL combined with etanercept pretreatment.
Phosphorylation (phosphorylated) of SNL in spinal cord associated with spinal nerve ligature, etanercept and spinal cord
2) Confidence 0.06 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12684435 Disease Relevance 0.73 Pain Relevance 1.83
Intrathecal D-JNKI-1 also suppressed SNL-induced phosphorylation of the JNK substrate, c-Jun, in spinal astrocytes.
Phosphorylation (phosphorylation) of SNL in spinal associated with spinal nerve ligature and intrathecal
3) Confidence 0.04 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16571763 Disease Relevance 0.71 Pain Relevance 1.83
Western blot and immunohistochemistry were performed to confirm the effects of these two agents, administered individually or together, on SNL-induced NMDA receptor phosphorylation and astrocytic activation.


Phosphorylation (phosphorylation) of SNL associated with nmda receptor and spinal nerve ligature
4) Confidence 0.04 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.50 Pain Relevance 1.67
Effects of ketamine on SNL-induced NMDAR phosphorylation
Phosphorylation (phosphorylation) of SNL associated with ketamine and spinal nerve ligature
5) Confidence 0.04 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.18 Pain Relevance 0.94
This study examined effects of age (young rats, approximately 35 days, vs mature rats, approximately 75-110 days) on spinal nerve ligation (SNL)-induced tactile allodynia and phosphorylation of p38 (as measured by phospho-p38 MAP kinase [P-p38]) in dorsal root ganglia and spinal cord.
Phosphorylation (phosphorylation) of SNL in spinal nerve associated with brush evoked pain, spinal nerve ligature and spinal cord
6) Confidence 0.03 Published 2006 Journal J Pain Section Abstract Doc Link 16632323 Disease Relevance 0.33 Pain Relevance 0.78

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