INT10980
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
HD2-Mns produced depolarizations with longer latencies and durations than those of the HD1-Mns. | |||||||||||||||
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On the other hand, cells expressing NUP98-HOXA9/N51S did not show morphologic evidence of erythroid immaturity in Giemsa-stained preparations (Fig. 8 and Table 1); yet a clear block in erythroid differentiation was observed by flow cytometry as evidenced by decreased expression of CD235a (Fig. 9A). | |||||||||||||||
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HD2-Mns produced depolarizations with longer latencies and durations than those of the HD1-Mns. | |||||||||||||||
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IS-5-MN is rapidly absorbed after oral administration and the maximum concentration in serum was reached 1.2 +/- 0.2 h after doses of 10 to 50 mg. | |||||||||||||||
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In contrast, no significant reduction in CD235a expression was seen in cells expressing HOXA9 and HOXA9? | |||||||||||||||
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It has been suggested that a central pattern generator that contains a serial network of linked neurons must produce the successive excitation of motoneurons (Mns) and then the sequential activation of muscle through excitatory connections. | |||||||||||||||
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These results show that MnPO neurons projecting to the PVN may carry the information from osmosensitive elements and that there is a difference between WKY and SHR in the responsivity of these MnPO neurons to the osmotic stimulation. | |||||||||||||||
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The gender difference in the mu suppression in the human MNS during action observation may result from nonspecifically physiologic as well as empathic gender differences. | |||||||||||||||
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Activation of MNS areas has been shown to increase during social interaction, as well as during observation and imitation of emotional faces [25]. | |||||||||||||||
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However this mutation is more likely to be involve in hereditary aging-related neurodegenerative disease, as shown by the finding that leukocytes lose the ability to induce Mn-SOD expression in response to increases in reactive oxygen species levels in tissue, in subjects over the age of 55 years [14]. | |||||||||||||||
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Mitochondrial Mn-SOD activity is preserved in recreationally active, but not sedentary, older adults | |||||||||||||||
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The Val variant of the Mn-SOD may be present in a lower concentration in mitochondria. | |||||||||||||||
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Odds ratios and 95% confidence interval (95% CI) were calculated to assess the strength of the relationship between the Mn-SOD or EC-SOD polymorphisms and DN.
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Both Mn-SOD and Cu/Zn-SOD activity were expressed in Umg protein? | |||||||||||||||
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The most consistent observation of these early studies was that Mn produced morphological changes in the globus pallidus, subthalamic nuclei, and substantia nigra pars reticulata, whereas the SNpc remained intact (Table 4). | |||||||||||||||
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This finding is likely because Mn is excreted in the bile, and in persons with chronic liver disease, the excretion of Mn is markedly impaired, with subsequent accumulation in the brain. | |||||||||||||||
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However, a firm conclusion that chronic Mn results in the loss of DAT and presumably dopamine neuron terminals in the striatum cannot be made because [11C]-nomifensine is not a selective DAT ligand and because Mn can directly inhibit ligand binding to DAT. | |||||||||||||||
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Also, the progression of Mn-induced parkinsonism appears to be a gait disorder of early onset with dystonia that occurs much later in the slow progression of the movement abnormalities in PD.
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Further, Mn exposure had no effect on D1R or cannabinoid receptor 1 levels in the basal ganglia. | |||||||||||||||
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From a clinical perspective, most persons who were occupationally exposed to Mn, users of ephedron, and patients with liver disease and parkinsonism are not responsive or are minimally responsive to l-dopa therapy, the mainstay therapy that ameliorates the early movement abnormalities in PD (Table 1). | |||||||||||||||
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