INT109800

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Context Info
Confidence 0.42
First Reported 2003
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 1.79
Pain Relevance 1.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Esr2) plasma membrane (Esr2) nucleus (Esr2)
enzyme binding (Esr2) DNA binding (Esr2) cytoplasm (Esr2)
Anatomy Link Frequency
uterus 1
neurons 1
uterine 1
autonomic 1
Esr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 2 99.56 Very High Very High Very High
orphanin 4 97.56 Very High Very High Very High
nud 4 97.40 Very High Very High Very High
Opioid 4 96.48 Very High Very High Very High
Neuropeptide 3 96.20 Very High Very High Very High
Nucleus accumbens 5 96.00 Very High Very High Very High
withdrawal 1 92.92 High High
Autonomic response 1 91.88 High High
Pain 33 91.40 High High
Inflammation 1 85.84 High High
Disease Link Frequency Relevance Heat
Adenocarcinoma 1 98.48 Very High Very High Very High
Dyspepsia 4 97.40 Very High Very High Very High
Uterine Cancer 1 97.36 Very High Very High Very High
Stress 55 92.16 High High
Pain 54 91.40 High High
Breast Cancer 4 79.92 Quite High
Galactorrhea 14 70.68 Quite High
Disease 2 70.00 Quite High
Cancer 2 67.52 Quite High
Nociception 24 59.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
(R)-(+)-7,9-difluoro-5-[4-(2-piperidin-1-ylethoxy)phenyl]-5H-6-oxachrysen-2-ol, LSN2120310, potently binds ERalpha and ERbeta and is an antagonist in MCF-7 breast adenocarcinoma and Ishikawa uterine cancer cell lines.
ERbeta Binding (binds) of in uterine associated with adenocarcinoma, uterine cancer and antagonist
1) Confidence 0.42 Published 2006 Journal J. Med. Chem. Section Abstract Doc Link 16451049 Disease Relevance 0.20 Pain Relevance 0.17
Potential interactions between the ERbeta and the well-characterized AVP-OXY neurosecretory system as well as the novel OFQ-ORL1 opioid neuropeptide system may provide new leads for the functional significance of ERbeta, specifically in stress/autonomic responses.
ERbeta Binding (interactions) of in autonomic associated with stress, autonomic response, neuropeptide and opioid
2) Confidence 0.34 Published 2003 Journal Anat. Embryol. Section Abstract Doc Link 12690447 Disease Relevance 0.09 Pain Relevance 0.58
Estrogen regulates neurons not only by binding to estrogen receptors (ERalpha and ERbeta) to initiate transcription but also via the G-protein coupled receptor GPR30, which binds and rapidly mediates actions of estrogen.
ERbeta Binding (binding) of in neurons
3) Confidence 0.30 Published 2009 Journal Gastroenterology Section Abstract Doc Link 19344720 Disease Relevance 0.27 Pain Relevance 0.22
Ovariectomized Sprague-Dawley rats were treated for 2 weeks with estradiol, a specific ligand for estrogen receptor alpha (ERalpha), 4,4',4-(4-propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol (PPT) and estrogen receptor beta (ERbeta) 2,3-bis(4-hydroxyphenyl)-propionitrile (DPN), or the selective estrogen receptor modulators (SERMs) tamoxifen and raloxifene.
ERbeta Binding (ligand) of
4) Confidence 0.28 Published 2005 Journal Psychoneuroendocrinology Section Abstract Doc Link 15511599 Disease Relevance 0 Pain Relevance 0.20
Recent data have shown that a metabolite of DHT, 5-alpha-androstane-3-beta-17-beta-diol (3-beta-diol), once considered inactive, is also present in high concentrations in the male and indeed has biological activity. 3-beta-diol does not bind to the androgen receptor, but rather to estrogen receptors ER-alpha and ER-beta, with higher affinity for ER-beta.
ER-beta Neg (not) Binding (bind) of
5) Confidence 0.22 Published 2006 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1615873 Disease Relevance 0 Pain Relevance 0
Moreover, equol appears to bind ER beta > ER alpha, similar to that of genistein [2].
ER beta Binding (bind) of
6) Confidence 0.10 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1276816 Disease Relevance 0.31 Pain Relevance 0.05
Apigenin has increased binding activity to ER beta, which appears to be involved in regulation of the mammary fat tissue, but has no effect on uterus and only little effect on bones (15).
ER beta Binding (activity) of in uterus
7) Confidence 0.09 Published 2008 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2529385 Disease Relevance 0.35 Pain Relevance 0.27
It is well established that genistein has a greater affinity for ER beta than ER alpha [3].
ER beta Binding (affinity) of
8) Confidence 0.08 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1276816 Disease Relevance 0.16 Pain Relevance 0.06
Experimental evidence found that A. castus demonstrates a significant competitive binding to estrogen receptors alpha (ER alpha) and beta (ER beta) as well as stimulating Progesterone Receptor expression (25).
ER beta Binding (binding) of
9) Confidence 0.08 Published 2008 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2529385 Disease Relevance 0.41 Pain Relevance 0.37

General Comments

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