INT10982

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Context Info
Confidence 0.58
First Reported 1992
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 42
Total Number 44
Disease Relevance 22.42
Pain Relevance 10.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Agtr1a) aging (Agtr1a) Golgi apparatus (Agtr1a)
plasma membrane (Agtr1a) cytoplasm (Agtr1a) signal transducer activity (Agtr1a)
Anatomy Link Frequency
plasma 2
medulla 2
brain 2
heart 2
brainstem 1
Agtr1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 184 100.00 Very High Very High Very High
Rostral ventrolateral medulla 21 99.84 Very High Very High Very High
Hyperalgesia 15 99.84 Very High Very High Very High
dorsal root ganglion 213 99.46 Very High Very High Very High
medulla 23 99.40 Very High Very High Very High
agonist 730 99.24 Very High Very High Very High
Chronic pancreatitis 4 98.52 Very High Very High Very High
Inflammation 62 98.48 Very High Very High Very High
cINOD 2 98.36 Very High Very High Very High
fibrosis 13 97.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Myocardial Infarction 237 99.84 Very High Very High Very High
Nerve Compression Syndromes 135 99.84 Very High Very High Very High
Hyperalgesia 16 99.84 Very High Very High Very High
Chronic Renal Failure 662 99.72 Very High Very High Very High
Natriuresis 17 99.66 Very High Very High Very High
Ganglion Cysts 216 99.46 Very High Very High Very High
Injury 30 99.24 Very High Very High Very High
Hypertension 35 99.20 Very High Very High Very High
Diabetes Mellitus 18 98.72 Very High Very High Very High
Pancreatitis 4 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This was followed by a significant downregulation of both mRNA and protein levels of AT1R in the ventrolateral medulla, alongside reduced efficacy of angiotensin II (50 pmol) to induce an increase in systemic arterial pressure, heart rate, or sympathetic vasomotor outflow on unilateral microinjection into the RVLM.
Negative_regulation (downregulation) of AT1R in heart associated with medulla and rostral ventrolateral medulla
1) Confidence 0.58 Published 2003 Journal Hypertension Section Abstract Doc Link 12810755 Disease Relevance 0.41 Pain Relevance 0.48
Downregulation of angiotensin subtype 1 receptor in rostral ventrolateral medulla during endotoxemia.
Negative_regulation (Downregulation) of angiotensin subtype 1 receptor in medulla associated with endotoxemia and rostral ventrolateral medulla
2) Confidence 0.58 Published 2003 Journal Hypertension Section Title Doc Link 12810755 Disease Relevance 0.41 Pain Relevance 0.36
Losartan is a novel orally active nonpeptidal antihypertensive agent that specifically blocks the angiotensin II type 1 receptor.
Negative_regulation (blocks) of angiotensin II type 1 receptor
3) Confidence 0.51 Published 1997 Journal Clin Ther Section Abstract Doc Link 9377606 Disease Relevance 0.27 Pain Relevance 0
The blockade of AT1 receptor results in enhanced stimulation of the AT2 receptor.
Negative_regulation (blockade) of AT1 receptor
4) Confidence 0.50 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291334 Disease Relevance 0.99 Pain Relevance 0
ARBs selectively block AT1 receptor activity with no blocking effect on the AT2 receptor.
Negative_regulation (block) of AT1 receptor
5) Confidence 0.50 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291334 Disease Relevance 1.04 Pain Relevance 0
ARBs have beneficial effects by blocking the AT1 receptor in heart failure.
Negative_regulation (blocking) of AT1 receptor in heart associated with myocardial infarction
6) Confidence 0.50 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291334 Disease Relevance 0.92 Pain Relevance 0.18
The current study was conducted to determine the potential influence of ibuprofen on the renal and systemic response to AT1 receptor blockade in conscious rats developing spontaneous hypertension.
Negative_regulation (blockade) of AT1 associated with hypertension
7) Confidence 0.43 Published 1999 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 9892151 Disease Relevance 0.35 Pain Relevance 0.08
These results demonstrate that nonsteroidal anti-inflammatory drug treatment has no effect on the antihypertensive efficacy and diuretic effects of AT1 receptor blockade in rats developing hypertension.
Negative_regulation (blockade) of AT1 associated with inflammation, hypertension and cinod
8) Confidence 0.43 Published 1999 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 9892151 Disease Relevance 0.27 Pain Relevance 0.14
Pretreatment with microinjection of a selective iNOS inhibitor, S-methylisothiourea (250 pmol) bilaterally into the RVLM significantly reversed the reduction in both synthesis and activity of AT1R.
Negative_regulation (reduction) of AT1R in RVLM associated with rostral ventrolateral medulla
9) Confidence 0.42 Published 2003 Journal Hypertension Section Abstract Doc Link 12810755 Disease Relevance 0.34 Pain Relevance 0.50
The purpose of the present study was to determine the effects of an angiotensin II (AII) AT1 antagonist, losartan 10, 15, and 20 mg/kg IP, and the AII AT2 antagonist, PD 123319, 20 mg/kg IP on ethanol (EtOH) intoxication as measured by the aerial righting reflex in male rats.
Negative_regulation (antagonist) of AT1 associated with antagonist and poisoning
10) Confidence 0.42 Published 1996 Journal Alcohol Section Abstract Doc Link 8734844 Disease Relevance 0.10 Pain Relevance 0.25
Our results demonstrate that adult rat skin contains predominantly AT1 receptors and also that these receptors are downregulated for 12-24 hours after wounding.
Negative_regulation (downregulated) of AT1 in skin
11) Confidence 0.41 Published 1992 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 1530605 Disease Relevance 0.15 Pain Relevance 0.08
We conclude that blockade of angiotensin II, AT1 receptors unmasks a vasodilator response to ET antagonists.
Negative_regulation (blockade) of AT1 associated with antagonist
12) Confidence 0.41 Published 2000 Journal Fundam Clin Pharmacol Section Abstract Doc Link 10796056 Disease Relevance 0.27 Pain Relevance 0.25
We investigated the effect of AT1 receptor blockade in the NTS on the response to stimulation of HDA in anaesthetised rats treated with the neuromuscular blocking agent pancuronium bromide.
Spec (investigated) Negative_regulation (blockade) of AT1 receptor
13) Confidence 0.40 Published 2003 Journal Exp. Physiol. Section Abstract Doc Link 12719755 Disease Relevance 0.09 Pain Relevance 0.12
RT-PCR data revealed that the AT1 receptor was down-regulated at 24 h after the pulp exposure.
Negative_regulation (down-regulated) of AT1 receptor
14) Confidence 0.40 Published 2007 Journal Regul. Pept. Section Abstract Doc Link 17197045 Disease Relevance 0.55 Pain Relevance 0.35
Angiotensin-converting enzyme inhibition or angiotensin II type 1 receptor blockade in neonatal, but not in weaned, rats induces irreversible renal histologic abnormalities and an impaired urinary concentrating ability.
Negative_regulation (blockade) of angiotensin II type 1 receptor associated with congenital anomalies
15) Confidence 0.40 Published 1999 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 10405211 Disease Relevance 0.10 Pain Relevance 0.06
We injected the AT1 and AT2 angiotensin II receptor antagonists, losartan and PD123319, L-NAME, 7-nitroindazole (nitric oxide synthetase inhibitors), and FK409 (nitric oxide donor agent) into the lateral ventricles.
Negative_regulation (antagonists) of AT1 in lateral ventricles
16) Confidence 0.38 Published 2007 Journal Anesth. Analg. Section Body Doc Link 17959957 Disease Relevance 0 Pain Relevance 0
Angiotensin receptor blockers (ARBs) specifically inhibit the AT1 receptor.
Negative_regulation (inhibit) of AT1 receptor
17) Confidence 0.37 Published 2007 Journal Vascular Health and Risk Management Section Abstract Doc Link PMC2291334 Disease Relevance 0.78 Pain Relevance 0
ARBs act by a different mechanism than ACE inhibitors by blocking the binding of angiotensin II to the AT1 receptor (Goodfriend et al 1996).
Negative_regulation (blocking) of AT1 receptor
18) Confidence 0.36 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291334 Disease Relevance 0.90 Pain Relevance 0.26
Exaggerated natriuresis after selective AT1 receptor blockade in Dahl salt-sensitive rats.
Negative_regulation (blockade) of AT1 receptor associated with natriuresis
19) Confidence 0.33 Published 2001 Journal Clin. Exp. Hypertens. Section Title Doc Link 11728007 Disease Relevance 0.20 Pain Relevance 0.12
AT1 receptor blockade with candesartan treatment in CRF rats was associated with decreased kidney weight and increased BUN levels, compared with CRF rats treated with vehicle alone.
Negative_regulation (blockade) of AT1 receptor in kidney associated with chronic renal failure
20) Confidence 0.29 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 1.21 Pain Relevance 0.03

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