INT109821

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Context Info
Confidence 0.55
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 21
Disease Relevance 6.86
Pain Relevance 3.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpv4) plasma membrane (Trpv4) cilium (Trpv4)
transmembrane transport (Trpv4)
Anatomy Link Frequency
pore 1
urothelial cell 1
endothelium 1
ciliary 1
carotid artery 1
Trpv4 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 90 100.00 Very High Very High Very High
allodynia 8 99.28 Very High Very High Very High
Mechanosensation 5 98.84 Very High Very High Very High
Hyperalgesia 32 98.72 Very High Very High Very High
qutenza 53 97.76 Very High Very High Very High
TRP channel 65 96.52 Very High Very High Very High
antagonist 74 93.72 High High
nociceptor 74 93.56 High High
Inflammatory mediators 13 90.76 High High
Inflammation 61 87.48 High High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 208 100.00 Very High Very High Very High
Stress 153 100.00 Very High Very High Very High
Targeted Disruption 66 99.96 Very High Very High Very High
Nociception 34 99.32 Very High Very High Very High
Neuropathic Pain 29 99.28 Very High Very High Very High
Hyperalgesia 46 98.72 Very High Very High Very High
Overactive Bladder 48 98.48 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

3 97.60 Very High Very High Very High
Pressure And Volume Under Development 54 95.56 Very High Very High Very High
Polycystic Kidney Disease 14 91.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Fig. 5, A and B, incubation of HEK-293 cells with cycloheximide (to block new protein synthesis) led to a substantial decrease in the TRPV4 levels in the cells.
Negative_regulation (decrease) of TRPV4
1) Confidence 0.55 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
Experiments were performed on 24–34 g adult male C57BL6 mice lacking a functional TRPV4 gene (TRPV4-/-) and TRPV4 wild-type (TRPV4+/+) littermates [5].
Negative_regulation (lacking) of TRPV4
2) Confidence 0.43 Published 2007 Journal Mol Pain Section Body Doc Link PMC2173885 Disease Relevance 0.73 Pain Relevance 0.54
Impaired pressure sensation in mice lacking TRPV4.
Negative_regulation (lacking) of TRPV4
3) Confidence 0.43 Published 2003 Journal J. Biol. Chem. Section Title Doc Link 12692122 Disease Relevance 0.08 Pain Relevance 0.16
The vasodilation elicited by sodium nitro prusside (SNP, 10 µmol/L) was similar in both groups (Fig. 3A and B), which thus suggests that TRPV4 deficiency does not compromise endothelium-independent relaxation of smooth muscle.
Negative_regulation (deficiency) of TRPV4 in endothelium associated with increased venous pressure under development
4) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1959246 Disease Relevance 0.26 Pain Relevance 0.05
mice, loss of the TRPV4 protein was confirmed by Western blot, immunohistochemistry and by in situ-patch–clamp techniques in carotid artery endothelial cells (CAEC).
Negative_regulation (loss) of TRPV4 in carotid artery
5) Confidence 0.43 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1959246 Disease Relevance 0.71 Pain Relevance 0
By using electrophysiology and intracellular calcium influx in rat and mouse TRPV4 channels, these authors demonstrated that RN-1734 completely inhibited both ligand- and hypotonicity-activated TRPV4.
Negative_regulation (inhibited) of TRPV4
6) Confidence 0.43 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948364 Disease Relevance 0.21 Pain Relevance 0.12
Furthermore, they found that mice lacking TRPV4 displayed a severely disturbed urine-voiding pattern.
Negative_regulation (lacking) of TRPV4 in urine associated with overactive bladder
7) Confidence 0.43 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948364 Disease Relevance 0.92 Pain Relevance 0.16
Similarly, only the nociceptive behavior caused by 2% saline was reduced in TRPV4(-/-) knockout mice.
Negative_regulation (reduced) of TRPV4 associated with targeted disruption and nociception
8) Confidence 0.43 Published 2005 Journal Pain Section Abstract Doc Link 16213085 Disease Relevance 0.88 Pain Relevance 0.54
Depletion of TRPV4 in renal epithelial cells abolishes flow-induced calcium transients, demonstrating that TRPV4, like TRPP2, is an essential component of the ciliary mechanosensor.
Negative_regulation (Depletion) of TRPV4 in ciliary
9) Confidence 0.42 Published 2008 Journal The Journal of Cell Biology Section Abstract Doc Link PMC2500130 Disease Relevance 0.17 Pain Relevance 0
However, the addition of angiotensin in addition to cycloheximide did not lead to any further decrease in TRPV4 levels in the cells.
Negative_regulation (decrease) of TRPV4
10) Confidence 0.40 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
Angiotensin Stimulation Leads to Internalization and Functional Down-regulation of TRPV4
Negative_regulation (regulation) of TRPV4
11) Confidence 0.40 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
-arrestin 1 in angiotensin-induced internalization and down-regulation of TRPV4 but also imply that the physical interaction between TRPV4 and ?
Negative_regulation (regulation) of TRPV4
12) Confidence 0.40 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
We pretreated rVSMCs with MG132 (to inhibit proteasomal degradation) followed by angiotensin stimulation and subsequent immunoprecipitation of TRPV4.
Negative_regulation (immunoprecipitation) of TRPV4
13) Confidence 0.40 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
Further, intracolonic administration of the PAR(4) agonist, but not the control peptide, was able to significantly inhibit PAR(2) agonist- and transcient receptor potential vanilloid-4 (TRPV4) agonist-induced allodynia and hyperalgesia in response to colorectal distension.
Negative_regulation (inhibit) of TRPV4 associated with hyperalgesia, allodynia and agonist
14) Confidence 0.40 Published 2009 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19413681 Disease Relevance 0.40 Pain Relevance 0.75
At 34 or 42 degrees C, barrier recovery was delayed compared with the un-occluded area. 4Alpha-phorbol 12,13-didecanone, an activator of TRPV4, accelerated barrier recovery, whereas ruthenium red, a blocker of TRPV4, delayed barrier recovery.
Negative_regulation (blocker) of TRPV4
15) Confidence 0.39 Published 2007 Journal J. Invest. Dermatol. Section Abstract Doc Link 17068482 Disease Relevance 0 Pain Relevance 0.14
Loss of shear stress-induced vasodilation in TRPV4?
Negative_regulation (Loss) of TRPV4 associated with stress and increased venous pressure under development
16) Confidence 0.38 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1959246 Disease Relevance 1.18 Pain Relevance 0.09
In an immunohistochemical study, TRPV4 was localized in basal and intermediate urothelial cell layers of mice bladders, and TRPV4 expression was also confirmed in primary cell cultures.
Negative_regulation (localized) of TRPV4 in urothelial cell
17) Confidence 0.37 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948364 Disease Relevance 0.11 Pain Relevance 0.36
Flow-dependent potassium secretion is a calcium-dependent process that is completely abolished in TRPV4 knockout mice (Taniguchi et al., 2007).
Negative_regulation (abolished) of TRPV4 associated with targeted disruption
18) Confidence 0.36 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.38 Pain Relevance 0
Indeed, mice lacking TRPV3 or TRPV4 have been reported to exhibit abnormal thermo-related behaviors [25, 28].
Negative_regulation (lacking) of TRPV4
19) Confidence 0.36 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2745623 Disease Relevance 0 Pain Relevance 0.26
However, mice deficient of TRPV2 and TRPV1 or TRPV3 or TRPV4 show no major impairment of noxious heat sensing.
Negative_regulation (deficient) of TRPV4
20) Confidence 0.34 Published 2009 Journal Exp Brain Res Section Abstract Doc Link 19404626 Disease Relevance 0.41 Pain Relevance 0.76

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