INT109822

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Context Info
Confidence 0.55
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 1.98
Pain Relevance 2.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpv4) plasma membrane (Trpv4) cilium (Trpv4)
transmembrane transport (Trpv4)
Anatomy Link Frequency
kidney 3
tail 2
urothelial cells 2
MDCK 2
ganglia 1
Trpv4 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 10 99.12 Very High Very High Very High
agonist 20 99.04 Very High Very High Very High
trigeminal ganglion 2 97.64 Very High Very High Very High
imagery 4 96.24 Very High Very High Very High
Inflammation 9 92.24 High High
Mechanosensation 4 89.92 High High
TRP channel 37 89.80 High High
nociceptor 3 85.92 High High
unmyelinated 2 83.84 Quite High
Nerve growth factor 1 83.60 Quite High
Disease Link Frequency Relevance Heat
Pain 9 99.12 Very High Very High Very High
Nociception 2 97.92 Very High Very High Very High
Ganglion Cysts 4 97.64 Very High Very High Very High
Pancreatitis 5 97.20 Very High Very High Very High
Targeted Disruption 19 96.56 Very High Very High Very High
INFLAMMATION 8 92.24 High High
Inflammatory Pain 1 78.64 Quite High
Neurogenic Inflammation 1 56.56 Quite High
Pressure And Volume Under Development 9 44.52 Quite Low
Overactive Bladder 16 29.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the addition of angiotensin in addition to cycloheximide did not lead to any further decrease in TRPV4 levels in the cells.
Negative_regulation (decrease) of Gene_expression (levels) of TRPV4
1) Confidence 0.55 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
In the present study, we show that disrupting the Trpv4 gene in mice markedly reduced the sensitivity of the tail to pressure and acidic nociception.
Negative_regulation (reduced) of Gene_expression (disrupting) of Trpv4 gene in tail associated with nociception
2) Confidence 0.43 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12692122 Disease Relevance 0.10 Pain Relevance 0.15
The functional expression of TRPV4 in urothelial cells was evidenced by using the selective agonist 4?
Negative_regulation (evidenced) of Gene_expression (expression) of TRPV4 in urothelial cells associated with agonist
3) Confidence 0.42 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948364 Disease Relevance 0 Pain Relevance 0.33
Deletion of trpv4 or trpa1 suppressed c-Fos expression and pain behavior, and deletion of trpa1 attenuated pancreatitis.
Negative_regulation (suppressed) of Gene_expression (Deletion) of trpv4 associated with pain and pancreatitis
4) Confidence 0.42 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20539005 Disease Relevance 1.59 Pain Relevance 1.34
After identifying two siRNA oligonucleotides that efficiently reduced expression of canine TRPV4 (Fig. 3 A), we generated polyclonal MDCK cells expressing TRPV4 siRNA under the control of the TET repressor; the expression of siRNA in individual cells was monitored by the concomitant expression of GFP (Fig. 3, B and C).
Negative_regulation (reduced) of Gene_expression (expression) of TRPV4 in MDCK
5) Confidence 0.42 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.10 Pain Relevance 0.07
Real-time PCR also demonstrated a significant down-regulation in TRPV4 mRNA expression in the inner ear ganglia and kidney after KM treatment.
Negative_regulation (down-regulation) of Gene_expression (expression) of TRPV4 in kidney
6) Confidence 0.41 Published 2005 Journal Hear. Res. Section Abstract Doc Link 15721568 Disease Relevance 0.10 Pain Relevance 0.22
It is also possible that decreased Ca2+ influx upon prestimulation with angiotensin results, in part, from cross-desensitization of TRPV4.

?

Spec (possible) Negative_regulation (possible) of Gene_expression (desensitization) of TRPV4
7) Confidence 0.40 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0.08
In the pathological condition, the expression of TRPV3, TRPV4, TRPM5, and TRPA1 was markedly reduced and recovery took a long time.
Negative_regulation (reduced) of Gene_expression (expression) of TRPV4
8) Confidence 0.39 Published 2010 Journal Acta Oto-Laryngologica Section Body Doc Link PMC2981077 Disease Relevance 0 Pain Relevance 0.13
Real-time PCR also demonstrated a significant down-regulation in TRPV4 mRNA expression in the inner ear ganglia and kidney after KM treatment.
Negative_regulation (down-regulation) of in ganglia Gene_expression (expression) of TRPV4 in kidney
9) Confidence 0.14 Published 2005 Journal Hear. Res. Section Abstract Doc Link 15721568 Disease Relevance 0.10 Pain Relevance 0.22

General Comments

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