INT10983

Context Info Confidence 0.45 First Reported 1980 Last Reported 2010 Negated 0 Speculated 1 Reported most in Abstract Documents 7 Total Number 8 Disease Relevance 4.21 Pain Relevance 0.52

lipid binding (Apoa2) protein folding (Apoa2) transport (Apoa2) extracellular space (Apoa2) extracellular region (Apoa2) cellular_component (Apoa2)

Anatomy Link Frequency ventricle 1 cardiovascular system 1 brain 1 skin 1 Apoa2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat anesthesia 5 97.20 Angina 2 95.84 Kinase C 10 87.88 Bioavailability 5 62.20 cva 3 56.56 aspirin 1 54.20 antagonist 7 36.24 Inflammation 5 5.00 Migraine 2 5.00 Calcium channel 2 5.00

Disease Link Frequency Relevance Heat Coronary Stenosis 20 100.00 Disorder Of Lipid Metabolism 18 100.00 Myocardial Infarction 8 100.00 Hypertension 9 99.42 Injury 6 98.68 Stress 15 96.12 Cv General 3 Under Development 5 95.84 Wound Healing 5 93.52 Increased Venous Pressure Under Development 27 87.88 Renal Disease 4 81.44

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Angiotensin (AII) is associated with increased vascular smooth muscle growth and we have found increased levels of tissue AII during healing of wounded skin.

AII Binding (associated) of in skin

1) Confidence 0.45 Published 1992 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 1530605 Disease Relevance 0.16 Pain Relevance 0.08

Intracranial injection of angiotensin II (AII) at three brain sites elicited near simultaneous dipsogenic and pressor effects in rats.

AII Binding (injection) of in brain

2) Confidence 0.35 Published 1980 Journal Am. J. Physiol. Section Abstract Doc Link 7435651 Disease Relevance 0 Pain Relevance 0

These results strongly suggest that hypertension in fructose-treated rats is associated with increased in vitro vascular reactivity to AII and PE in the early stages of hypertension.

AII Binding (associated) of associated with hypertension

3) Confidence 0.30 Published 1996 Journal Clin. Exp. Hypertens. Section Abstract Doc Link 8869002 Disease Relevance 0.35 Pain Relevance 0

Specific binding of 125I-AII was significantly decreased at 12, 18 and 24 hours in the wounded tissue compared to control tissue from the same rat.

AII Binding (binding) of

4) Confidence 0.29 Published 1992 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 1530605 Disease Relevance 0.17 Pain Relevance 0.10

The levels of 125I-Sar1.Ile8-AII bound to membrane preparations of the wound tissues decreased at early time points (from 0.5 to 4 h), increased from day 1 to day 7, and returned to nonsurgical levels by day 10.

Ile8-AII Binding (bound) of associated with injury

5) Confidence 0.20 Published 1996 Journal J Invest Surg Section Abstract Doc Link 8981218 Disease Relevance 0.53 Pain Relevance 0.09

Conclusions for this patient group (with low HDL-cholesterol): HDL3-cholesterol, and not HDL2-cholesterol, is informative for CAS; HDL(3)-cholesterol, apo-AI, or apo-AII, as well as CAS and PMI, are associated with LVEF.

apo-AII Binding (associated) of associated with coronary stenosis, myocardial infarction and disorder of lipid metabolism

6) Confidence 0.02 Published 1987 Journal J. Lab. Clin. Med. Section Abstract Doc Link 3098880 Disease Relevance 1.51 Pain Relevance 0

We examined the association of cholesterol levels in serum lipoprotein fractions, as well as of serum apolipoprotein-AI (apo-AI) and apo-AII levels, with coronary artery stenosis (CAS) and left ventricle function in a group of 43 patients with angina pectoris (33 men and 10 women) subjected to angiography.

apo-AII Spec (examined) Binding (association) of in ventricle associated with coronary stenosis, angina and disorder of lipid metabolism

7) Confidence 0.02 Published 1987 Journal J. Lab. Clin. Med. Section Abstract Doc Link 3098880 Disease Relevance 0.72 Pain Relevance 0.10

In these effects an activated ET is likely to mediate the activity of the AII through NOX activation as AII-evoked expression of ET-1 in adventitial fibroblasts appears to be mediated, at least in part, by NOX.66 The mitochondrial ROS is responsible to mediate the activity of ET-1 in the cardiovascular system.67 The vascular activity of AII is closely related to ET-1, coronary vasoconstriction by ?

AII Binding (activity) of in cardiovascular system associated with increased venous pressure under development

8) Confidence 0.02 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941789 Disease Relevance 0.77 Pain Relevance 0.16

General Comments

This test has worked.