INT109833

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Context Info
Confidence 0.48
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 13
Disease Relevance 8.83
Pain Relevance 2.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (GNB3) plasma membrane (GNB3) GTPase activity (GNB3)
signal transducer activity (GNB3)
Anatomy Link Frequency
sympathetic 1
bowel 1
GNB3 (Homo sapiens)
GNB3 - C825T (6)
Pain Link Frequency Relevance Heat
nud 324 100.00 Very High Very High Very High
depression 7 99.60 Very High Very High Very High
Serotonin 13 97.16 Very High Very High Very High
Angina 2 96.24 Very High Very High Very High
abdominal pain 6 95.76 Very High Very High Very High
spastic colon 44 94.08 High High
Neurotransmitter 2 84.96 Quite High
Triptan 1 83.84 Quite High
Clonidine 9 75.36 Quite High
Raphe 1 71.36 Quite High
Disease Link Frequency Relevance Heat
Dyspepsia 322 100.00 Very High Very High Very High
Hypertension 9 99.76 Very High Very High Very High
Syndrome 271 99.60 Very High Very High Very High
Depression 7 99.60 Very High Very High Very High
Gastroesophageal Reflux Disease 60 99.48 Very High Very High Very High
Gastrointestinal Disease 42 97.72 Very High Very High Very High
Weight Gain 1 96.40 Very High Very High Very High
Cv General 3 Under Development 2 96.24 Very High Very High Very High
Abdominal Pain 6 95.76 Very High Very High Very High
Vomiting 6 94.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We evaluated the association of the GNB3 C825T polymorphism with GERD and GERD subgroups classified according to esophageal acid exposure time, symptom-reflux correlation, or coexistence of FD and/or irritable bowel syndrome (IBS) symptoms.
GNB3 (C825T) Binding (association) of in bowel associated with spastic colon, gastroesophageal reflux disease and nud
1) Confidence 0.48 Published 2009 Journal Am. J. Gastroenterol. Section Abstract Doc Link 19174793 Disease Relevance 1.16 Pain Relevance 0.37
CONCLUSIONS: GERD is associated with GNB3 C825T.
GNB3 (C825T) Binding (associated) of
2) Confidence 0.48 Published 2009 Journal Am. J. Gastroenterol. Section Body Doc Link 19174793 Disease Relevance 0.14 Pain Relevance 0
We demonstrated an association between homozygous GNB3 825T and EPS-like dyspepsia.
GNB3 Binding (association) of associated with syndrome and nud
3) Confidence 0.45 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2825227 Disease Relevance 1.52 Pain Relevance 0.25
We have therefore examined the effects of lifestyle modification on top of current treatment and also associated with the GNB3 C825T polymorphism, which has established association to sympathetic activation and the precipitation of angina.
GNB3 (C825T) Spec (examined) Binding (associated) of in sympathetic associated with angina
4) Confidence 0.36 Published 2006 Journal Am. Heart J. Section Abstract Doc Link 16569552 Disease Relevance 0.34 Pain Relevance 0.17
The 825T allele of a common C825T polymorphism in the gene, GNB3, encoding the G beta 3 subunit, was found to be associated with increased intracellular signal transduction via G protein-coupled receptors.
GNB3 Binding (associated) of
5) Confidence 0.35 Published 2003 Journal Kidney Int. Suppl. Section Abstract Doc Link 12694337 Disease Relevance 0.23 Pain Relevance 0.11
GNB3 C825T polymorphism has been associated with treatment response in various antipsychotic drugs [25] as well as clozapine induced weight gain [26].
GNB3 (C825T) Binding (associated) of associated with weight gain
6) Confidence 0.35 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC1888684 Disease Relevance 0.62 Pain Relevance 0.29
A logistic regression analysis was performed to test the influence of several factors in the association between the GNB3 C825T polymorphism genotype distribution and dyspepsia.
GNB3 C825T (C825T) Binding (association) of associated with nud
7) Confidence 0.35 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2825227 Disease Relevance 0.53 Pain Relevance 0.15
Furthermore, meal-unrelated dyspepsia has been associated with both the homozygous GNB3 825T and C genotypes from the US [15].
GNB3 Binding (associated) of associated with nud
8) Confidence 0.35 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2825227 Disease Relevance 1.00 Pain Relevance 0.28
Further studies are needed to evaluate, in detail, the association between GNB3 polymorphism and symptoms in subjects who visit primary, secondary or tertiary care centers.
GNB3 Binding (association) of
9) Confidence 0.33 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2825227 Disease Relevance 0.92 Pain Relevance 0.15
We also investigated the association between GNB3 polymorphism and each of eight different types of dyspeptic symptoms.
GNB3 Binding (association) of
10) Confidence 0.33 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2825227 Disease Relevance 1.11 Pain Relevance 0.28
In this study, we assessed the potential association of symptoms of dyspepsia with GNB3 C825T allele status.
GNB3 C825T (C825T) Binding (association) of associated with nud
11) Confidence 0.33 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2825227 Disease Relevance 0.77 Pain Relevance 0.21
The T allele of the C825T polymorphism in the gene encoding the G-protein beta 3 subunit (GNB3) is associated with hypertension.
GNB3 Binding (associated) of associated with hypertension
12) Confidence 0.29 Published 2003 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 12844135 Disease Relevance 0.16 Pain Relevance 0.28
The T allele of the C825T polymorphism in the gene encoding the G-protein beta 3 subunit (GNB3) is associated with hypertension.
G-protein beta 3 subunit Binding (associated) of associated with hypertension
13) Confidence 0.25 Published 2003 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 12844135 Disease Relevance 0.16 Pain Relevance 0.28

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