INT109838

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Context Info
Confidence 0.67
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 5.26
Pain Relevance 4.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkce) Golgi apparatus (Prkce) endoplasmic reticulum (Prkce)
enzyme binding (Prkce) cytoplasm (Prkce) cytosol (Prkce)
Anatomy Link Frequency
myocardium 2
neurons 1
DRG 1
Prkce (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 6 100.00 Very High Very High Very High
dorsal root ganglion 10 99.84 Very High Very High Very High
Periaqueductal grey 8 99.68 Very High Very High Very High
ischemia 12 98.78 Very High Very High Very High
Opioid 4 98.76 Very High Very High Very High
Eae 8 98.48 Very High Very High Very High
opioid receptor 10 98.24 Very High Very High Very High
Lasting pain 1 98.08 Very High Very High Very High
Pain 12 97.96 Very High Very High Very High
Inflammation 14 95.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 12 99.84 Very High Very High Very High
Urological Neuroanatomy 8 99.68 Very High Very High Very High
Cv Unclassified Under Development 12 98.78 Very High Very High Very High
Injury 6 98.48 Very High Very High Very High
Pain 4 98.08 Very High Very High Very High
INFLAMMATION 10 95.88 Very High Very High Very High
Nociception 4 95.88 Very High Very High Very High
Herpes Simplex Virus 1 92.24 High High
Hyperalgesia 4 82.12 Quite High
Neuropathic Pain 8 75.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that phosphorylation of Cx43 by PKC-epsilon plays a crucial role in delta-opioid-induced suppression of GJ permeability in ischemic myocardium and that this modulation of the GJ is possibly an adjunct mechanism of infarct size limitation afforded by preischemic delta-opioid receptor activation.
Phosphorylation (phosphorylation) of PKC-epsilon in myocardium associated with opioid receptor and opioid
1) Confidence 0.67 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 17513490 Disease Relevance 0.36 Pain Relevance 0.50
Delta-opioid receptor activation before ischemia reduces gap junction permeability in ischemic myocardium by PKC-epsilon-mediated phosphorylation of connexin 43.
Phosphorylation (phosphorylation) of PKC-epsilon in myocardium associated with ischemia and opioid receptor
2) Confidence 0.67 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Title Doc Link 17513490 Disease Relevance 0.47 Pain Relevance 0.55
A double-labeling study showed that phosphorylation of PKCepsilon was expressed predominantly in VR1 immunoreactivity positive small diameter DRG neurons mediating the nociceptive information from peripheral tissue to spinal cord.
Phosphorylation (phosphorylation) of PKCepsilon in neurons associated with nociception, dorsal root ganglion and spinal cord
3) Confidence 0.21 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12694383 Disease Relevance 1.38 Pain Relevance 0.88
Quantitative analysis showed that phosphorylation of PKCepsilon in DRG neurons was significantly up-regulated after carrageen- and Complete Freund's Adjuvant-induced inflammation, while it was markedly down-regulated after chronic constriction injury.
Phosphorylation (phosphorylation) of PKCepsilon in DRG associated with dorsal root ganglion, inflammation, eae and injury
4) Confidence 0.21 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12694383 Disease Relevance 1.15 Pain Relevance 0.62
Phosphorylation of the vanilloid receptor (TRPV1) by protein kinase C epsilon (PKCepsilon) plays an important role in the development of chronic pain.
Phosphorylation (Phosphorylation) of PKCepsilon associated with kinase c and lasting pain
5) Confidence 0.19 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18973552 Disease Relevance 0.32 Pain Relevance 0.59
A single oral administration of SJW produced a significant decrease of the PKCgamma (131.8+/-10.0) and PKCepsilon (105.2+/-12.0) phosphorylation in the PAG area due to the presence of hypericin.
Phosphorylation (phosphorylation) of PKCepsilon associated with periaqueductal grey
6) Confidence 0.08 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20045676 Disease Relevance 0.76 Pain Relevance 0.89
Mechanistic studies showed a robust over-expression and hyperphosphorylation of the PKCgamma (227.0+/-15.0% of control) and PKCepsilon (213.9+/-17.0) isoforms in the rat PAG area.
Phosphorylation (hyperphosphorylation) of PKCepsilon associated with periaqueductal grey
7) Confidence 0.07 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20045676 Disease Relevance 0.81 Pain Relevance 0.91

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