INT109848

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Context Info
Confidence 0.62
First Reported 2003
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 26
Total Number 26
Disease Relevance 6.71
Pain Relevance 4.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (P2RY1) aging (P2RY1) plasma membrane (P2RY1)
signal transducer activity (P2RY1)
Anatomy Link Frequency
platelets 9
1321N1 2
monocytes 1
lymphocytes 1
Sympathetic 1
P2RY1 (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 115 99.90 Very High Very High Very High
agonist 166 99.72 Very High Very High Very High
substance P 4 99.20 Very High Very High Very High
antagonist 229 98.68 Very High Very High Very High
Calcitonin gene-related peptide 8 98.56 Very High Very High Very High
Immobilon 9 97.80 Very High Very High Very High
Pain 37 97.60 Very High Very High Very High
Action potential 10 96.36 Very High Very High Very High
aspirin 294 92.84 High High
Lasting pain 1 92.24 High High
Disease Link Frequency Relevance Heat
Anaplastic Astrocytoma 12 99.72 Very High Very High Very High
Polycystic Ovary Syndrome 9 98.92 Very High Very High Very High
Targeted Disruption 62 98.60 Very High Very High Very High
Pain 39 97.60 Very High Very High Very High
Myocardial Infarction 157 96.96 Very High Very High Very High
Acute Coronary Syndrome 27 96.44 Very High Very High Very High
Cv Unclassified Under Development 41 94.12 High High
Heart Rate Under Development 71 93.52 High High
Increased Venous Pressure Under Development 245 93.44 High High
Peripheral Arterial Disease 18 93.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
P2Y1 is a Gq protein linked ADP receptor expressed in platelets that mediates shape change [25,26].
Gene_expression (expressed) of ADP receptor in platelets
1) Confidence 0.62 Published 2005 Journal Thromb J Section Body Doc Link PMC1192820 Disease Relevance 0.48 Pain Relevance 0.34
P2Y1 is a Gq protein linked ADP receptor expressed in platelets that mediates shape change [25,26].
Gene_expression (expressed) of P2Y1 in platelets
2) Confidence 0.62 Published 2005 Journal Thromb J Section Body Doc Link PMC1192820 Disease Relevance 0.49 Pain Relevance 0.34
RT-PCR and immunocytochemistry indicated the additional presence of endogenous P2Y1 and to some extent P2Y4 receptors.
Gene_expression (presence) of P2Y1
3) Confidence 0.62 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12694404 Disease Relevance 0 Pain Relevance 0.13
It is also plausible that the second ADP receptor expressed on human platelets, P2Y1, may be involved in the insufficient inhibition of ADP-mediated platelet activation after clopidogrel treatment.
Gene_expression (expressed) of ADP receptor in platelet
4) Confidence 0.62 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096644 Disease Relevance 0.37 Pain Relevance 0.05
Animal studies have shown a correlation between function and overexpression of P2Y1 protein, but we could not find this association in our clinical material [27].
Gene_expression (overexpression) of P2Y1
5) Confidence 0.62 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096644 Disease Relevance 0.15 Pain Relevance 0.15
P2Y1 and P2Y12 receptor expression on both RNA and protein level were determined, as well as the P2Y12 H1 or H2 haplotypes.
Gene_expression (expression) of P2Y1
6) Confidence 0.62 Published 2006 Journal Purinergic Signal Section Abstract Doc Link PMC2096644 Disease Relevance 0.17 Pain Relevance 0.05
It is also plausible that the second ADP receptor expressed on human platelets, P2Y1, may be involved in the insufficient inhibition of ADP-mediated platelet activation after clopidogrel treatment.
Gene_expression (expressed) of P2Y1 in platelet
7) Confidence 0.62 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096644 Disease Relevance 0.37 Pain Relevance 0.03
The U87 cells mainly express P2Y1 purinergic receptors [39] and it has recently been reported that agonist-mediated endocytosis of P2Y1 purinergic receptors occurs over a period of 30 minutes, with recycling of endocytosed receptors occurring over a period of approximately 60 minutes [40].
Gene_expression (express) of P2Y1 associated with agonist
8) Confidence 0.58 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2955562 Disease Relevance 0 Pain Relevance 0.22
The blocking of the P2Y1 receptor with MRS 2179 (10 ?
Gene_expression (receptor) of P2Y1
9) Confidence 0.54 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096644 Disease Relevance 0 Pain Relevance 0.09
Sequential detection of P2Y1 and P2Y12 (at 1:200 dilution) and GAPDH (at 1:500 dilution) was performed according to the following procedure in the above-mentioned order.
Gene_expression (detection) of P2Y1
10) Confidence 0.54 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096644 Disease Relevance 0 Pain Relevance 0.05
Residual platelet ADP reactivity after clopidogrel treatment is dependent on activation of both the unblocked P2Y1 and the P2Y12 receptor and is correlated with protein expression of P2Y12

Two ADP receptors have been identified on human platelets: P2Y1 and P2Y12.

Gene_expression (expression) of P2Y1 in platelet
11) Confidence 0.54 Published 2006 Journal Purinergic Signal Section Title Doc Link PMC2096644 Disease Relevance 0.17 Pain Relevance 0.04
Figure 2The relative expression and GAPDH-normalized expression of P2Y12 (a) and P2Y1 (b) protein correlated with the percentage of P-selectin positive platelets after stimulation with 1 ?
Gene_expression (expression) of P2Y1 in platelets
12) Confidence 0.48 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096644 Disease Relevance 0.07 Pain Relevance 0.06
In (b) there is no significant correlation of P-selectin positive platelets and P2Y1 protein expression (r2=0.002, P=0.88, n=14) (pos plts positive platelets)
Gene_expression (expression) of P2Y1 in platelets associated with polycystic ovary syndrome
13) Confidence 0.48 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096644 Disease Relevance 0.10 Pain Relevance 0
1321N1 human astrocytoma cells stably expressing the human P2Y1, P2Y2, P2Y4, and P2Y6 receptors were grown in DMEM containing 4.5 g/l glucose, 5% fetal bovine serum and 600 µg/ml G-418.
Gene_expression (expressing) of P2Y1 in 1321N1 associated with anaplastic astrocytoma
14) Confidence 0.37 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096529 Disease Relevance 0.39 Pain Relevance 0.07
The platelets also express P2Y1 receptors that have been shown in knockout mice to be of similar importance as P2Y12 receptors [200, 203].
Gene_expression (express) of P2Y1 in platelets associated with targeted disruption
15) Confidence 0.33 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 0.32 Pain Relevance 0.05
Changes in fluorescence data corresponding to concentrations of intracellular Ca2+ were normalized to the response of the cognate agonists (2MeSADP for P2Y1 receptor, ATP for P2Y2 receptor, UTP for P2Y4 receptor, and UDP for P2Y6 receptor).
Gene_expression (receptor) of P2Y1 associated with agonist
16) Confidence 0.32 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096529 Disease Relevance 0 Pain Relevance 0.22
Dulbecco's modified Eagle's medium (DMEM), fetal bovine serum G-418, and other cell culture reagents were obtained from the Tissue Culture Facility at the University of North Carolina, or from Gibco-BRL Life Technologies (Rockville, MD). 1321N1 human astrocytoma cells stably expressing the P2Y1, P2Y2, P2Y4, or P2Y6 receptors, and wild-type 1321N1 cell were obtained from the University of North Carolina at Chapel Hill.


Gene_expression (expressing) of P2Y1 in 1321N1 associated with anaplastic astrocytoma
17) Confidence 0.32 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096529 Disease Relevance 0.41 Pain Relevance 0.10
The identity of the nucleobases in these dinucleotides was not responsible for the presence or lack of activity except for the necessity of adenosine for P2Y1 agonism and uridine for P2Y6 agonism.
Gene_expression (agonism) of P2Y1 associated with adenocard
18) Confidence 0.28 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096529 Disease Relevance 0 Pain Relevance 0.38
Sympathetic nerves express inhibitory P2Y and P1 (A1) receptors indicating a P2 receptor-mediated negative feedback loop both directly by ATP and its degradation product adenosine [34, 35].
Gene_expression (express) of P2Y in Sympathetic associated with adenocard
19) Confidence 0.26 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 0.48 Pain Relevance 0.27
At the mRNA level, the P2Y12 receptor is the highest expressed ADP receptor and the second highest expressed P2 receptor in human VSMC [46].
Gene_expression (expressed) of ADP receptor
20) Confidence 0.26 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 0.46 Pain Relevance 0

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