INT109851

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Context Info
Confidence 0.57
First Reported 2003
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 3.55
Pain Relevance 3.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2RX3) transport (P2RX3) Golgi apparatus (P2RX3)
Anatomy Link Frequency
urinary bladder 1
nerve 1
body 1
P2RX3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 107 98.56 Very High Very High Very High
Inflammation 36 98.44 Very High Very High Very High
Neuropathic pain 11 97.76 Very High Very High Very High
Perioperative pain 1 96.80 Very High Very High Very High
Osteoarthritis 45 95.88 Very High Very High Very High
IPN 8 95.80 Very High Very High Very High
Lasting pain 23 94.04 High High
adenocard 10 93.84 High High
antagonist 16 91.00 High High
Neuropeptide 2 88.88 High High
Disease Link Frequency Relevance Heat
Pain 135 98.56 Very High Very High Very High
Overactive Bladder 9 98.56 Very High Very High Very High
INFLAMMATION 44 98.44 Very High Very High Very High
Neuropathic Pain 26 97.76 Very High Very High Very High
Post Operative Pain 1 96.80 Very High Very High Very High
Frailty 48 95.88 Very High Very High Very High
Inflammatory Pain 8 95.80 Very High Very High Very High
Injury 11 86.40 High High
Hypersensitivity 5 84.80 Quite High
Pressure And Volume Under Development 1 65.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of P2X3 receptors is effective in reducing pain behaviors in animal models of chronic inflammatory and neuropathic pain.
Negative_regulation (Inhibition) of P2X3 associated with pain, inflammation and neuropathic pain
1) Confidence 0.57 Published 2005 Journal Curr Opin Investig Drugs Section Abstract Doc Link 15675605 Disease Relevance 1.36 Pain Relevance 1.04
For P2X receptors, there is a significant body of information indicating that inhibition of P2X3 receptors may be useful for relieving inflammatory and neuropathic pain.
Negative_regulation (inhibition) of P2X3 in body associated with inflammation and neuropathic pain
2) Confidence 0.57 Published 2007 Journal Handb Exp Pharmacol Section Abstract Doc Link 17087128 Disease Relevance 0.81 Pain Relevance 0.96
The present study indicates that in HEK293-hP2X3 cells, TCE, but not ethanol, potently inhibits ligand-gated P2X3 receptors and, in addition, moderately interferes with G protein-coupled P2Y1 and P2Y4 receptors.
Negative_regulation (inhibits) of P2X3
3) Confidence 0.41 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12694404 Disease Relevance 0 Pain Relevance 0.24
There was a significant decrease in P2X3 immunoreactivity in responders to RTX, indicating a potential pathophysiological role for the P2X3 expressing fibres.


Negative_regulation (decrease) of P2X3
4) Confidence 0.41 Published 2004 Journal Eur. Urol. Section Body Doc Link 15245821 Disease Relevance 0 Pain Relevance 0
In the 5 patients who responded to RTX, there was a significant decrease in P2X3-positive fibres (p=0.032), whereas in non-responders, P2X3-IR nerve fibre density did not change significantly.
Negative_regulation (decrease) of P2X3 in nerve
5) Confidence 0.36 Published 2004 Journal Eur. Urol. Section Body Doc Link 15245821 Disease Relevance 0 Pain Relevance 0
This was correlated with loss of both P2X3 and VR1 receptors in the urinary bladder [164].


Negative_regulation (loss) of P2X3 in urinary bladder
6) Confidence 0.27 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 0.93 Pain Relevance 0.93
This has been substantiated by the development by Abbott of a small molecule that selectively blocks P2X3 subunit-containing P2X receptors, and which is effective in a range of animal models of neuropathic and chronic inflammatory pain.
Negative_regulation (blocks) of P2X3 subunit associated with ipn and neuropathic pain
7) Confidence 0.09 Published 2003 Journal Curr Opin Investig Drugs Section Abstract Doc Link 14619405 Disease Relevance 0.45 Pain Relevance 0.44

General Comments

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