INT109852

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Context Info
Confidence 0.35
First Reported 2002
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.04
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (P2RY1) aging (P2RY1) plasma membrane (P2RY1)
signal transducer activity (P2RY1)
Anatomy Link Frequency
endothelium 1
platelet 1
A11 1
P2RY1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 27 97.48 Very High Very High Very High
Potency 1 80.76 Quite High
noradrenaline 18 78.44 Quite High
Inflammation 42 76.00 Quite High
antagonist 40 70.04 Quite High
adenocard 27 58.56 Quite High
Neuropeptide 9 54.48 Quite High
Pain 13 41.12 Quite Low
Root ganglion neuron 1 40.00 Quite Low
Migraine 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 122 98.20 Very High Very High Very High
Hemorrhage 4 88.76 High High
Stress 32 83.68 Quite High
Cv Unclassified Under Development 18 80.32 Quite High
Reperfusion Injury 2 79.52 Quite High
Thrombosis 18 76.44 Quite High
INFLAMMATION 42 76.00 Quite High
Hypoxia 12 72.16 Quite High
Targeted Disruption 30 70.04 Quite High
Injury 4 29.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The receptors with known ligands in group A11 are the P2Y receptors, which bind pyrimidine as well as purine nucleotides (Figure 5).
P2Y Binding (bind) of in A11
1) Confidence 0.35 Published 2002 Journal Genome Biol Section Body Doc Link PMC133447 Disease Relevance 0 Pain Relevance 0.03
Characterization of P2X3, P2Y1 and P2Y4 receptors in cultured HEK293-hP2X3 cells and their inhibition by ethanol and trichloroethanol.
P2Y1 Binding (Characterization) of
2) Confidence 0.34 Published 2003 Journal J. Neurochem. Section Title Doc Link 12694404 Disease Relevance 0 Pain Relevance 0.12
This platelet hypofunction was reversible and associated with P2Y1 receptor desensitisation.
P2Y1 Binding (associated) of in platelet
3) Confidence 0.21 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 0.63 Pain Relevance 0.16
The released ATP then binds to P2Y receptors on the endothelium and stimulates vasodilatation.
P2Y Binding (binds) of in endothelium associated with increased venous pressure under development
4) Confidence 0.16 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 0.41 Pain Relevance 0.03

General Comments

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