INT109859

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Context Info
Confidence 0.54
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.09
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Rhoa) mitochondrion (Rhoa) cell morphogenesis (Rhoa)
intracellular (Rhoa) GTPase activity (Rhoa) cytoplasm (Rhoa)
Anatomy Link Frequency
smooth muscle 1
platelet 1
Rhoa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 4 84.16 Quite High
cytokine 2 66.60 Quite High
addiction 6 61.88 Quite High
fibrosis 2 61.64 Quite High
dexamethasone 6 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Primary Sclerosing Cholangitis 10 91.36 High High
Apoptosis 4 89.80 High High
Hepatocellular Cancer 8 78.36 Quite High
Pancreatitis 4 63.40 Quite High
Fibrosis 2 61.64 Quite High
Stress 2 52.24 Quite High
Adhesions 2 50.32 Quite High
Volume Depletion And Dehydration 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of alpha-smooth muscle actin (an indicator of the myofibroblastic phenotype), ERK activation and membrane translocation of the Ras superfamily member RhoA were analysed by immunoblotting.
Localization (translocation) of RhoA in smooth muscle
1) Confidence 0.54 Published 2003 Journal Biochem. Pharmacol. Section Abstract Doc Link 12694870 Disease Relevance 0.61 Pain Relevance 0.13
Immunoblot experiments indicated that lovastatin suppressed both Ras-mediated ERK 1/2 activation and platelet-derived growth factor-induced membrane translocation of RhoA.
Localization (translocation) of RhoA in platelet
2) Confidence 0.54 Published 2003 Journal Biochem. Pharmacol. Section Abstract Doc Link 12694870 Disease Relevance 0.30 Pain Relevance 0.08
Activated RhoA may uncouple peroxisomes from microtubules as typical microtubule-dependent long-range saltations are no longer observed.


Localization (saltations) of RhoA
3) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2975642 Disease Relevance 0 Pain Relevance 0
This localization of RhoA to discrete domains of the peroxisomal membrane is reminiscent to the distribution of Pex11?
Localization (localization) of RhoA
4) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2975642 Disease Relevance 0.18 Pain Relevance 0.03

General Comments

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