INT109861

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Context Info
Confidence 0.78
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 11
Total Number 13
Disease Relevance 5.67
Pain Relevance 4.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Rhoa) mitochondrion (Rhoa) cell morphogenesis (Rhoa)
intracellular (Rhoa) GTPase activity (Rhoa) cytoplasm (Rhoa)
Anatomy Link Frequency
dorsal 1
hepatocytes 1
smooth muscle 1
spinal cord 1
muscles 1
Rhoa (Rattus norvegicus)
Rhoa - G14V (1)
Pain Link Frequency Relevance Heat
Inflammation 12 100.00 Very High Very High Very High
Neuritis 32 97.84 Very High Very High Very High
Spinal cord 200 96.48 Very High Very High Very High
Hippocampus 24 96.12 Very High Very High Very High
Peripheral nervous system 4 95.72 Very High Very High Very High
dexamethasone 6 94.64 High High
agonist 2 89.40 High High
tetrodotoxin 2 89.36 High High
Peripheral nerve injury 1 76.96 Quite High
Neuropathic pain 1 75.76 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 7 99.84 Very High Very High Very High
Syndrome 4 99.32 Very High Very High Very High
Experimental Autoimmune Neuritis 32 98.08 Very High Very High Very High
Apoptosis 86 94.48 High High
Spinal Cord Injury 99 93.72 High High
Primary Sclerosing Cholangitis 5 91.36 High High
Injury 16 89.80 High High
Hepatocellular Cancer 8 88.68 High High
Frailty 5 83.12 Quite High
Infection 12 82.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of RhoA by inflammatory macrophages and T cells in rat experimental autoimmune neuritis.
Gene_expression (Expression) of RhoA in T cells associated with inflammation, experimental autoimmune neuritis and neuritis
1) Confidence 0.78 Published 2007 Journal J. Cell. Mol. Med. Section Title Doc Link 17367505 Disease Relevance 0.76 Pain Relevance 0.83
In this study, RhoA expression has been investigated in the dorsal/ventral roots of EAN rats by immunohistochemistry.
Gene_expression (expression) of RhoA in ventral roots associated with neuritis
2) Confidence 0.67 Published 2007 Journal J. Cell. Mol. Med. Section Abstract Doc Link 17367505 Disease Relevance 0.75 Pain Relevance 0.66
Expression of alpha-smooth muscle actin (an indicator of the myofibroblastic phenotype), ERK activation and membrane translocation of the Ras superfamily member RhoA were analysed by immunoblotting.
Spec (analysed) Gene_expression (Expression) of RhoA in smooth muscle
3) Confidence 0.59 Published 2003 Journal Biochem. Pharmacol. Section Abstract Doc Link 12694870 Disease Relevance 0.64 Pain Relevance 0.14
Further, P2X4R+ cells coexpressed the intracellular regulators of signalling cascades, COX-1 (>20%), COX-2 (>5%), RhoA (>60%) and RhoB (>10%).
Gene_expression (coexpressed) of RhoA
4) Confidence 0.54 Published 2005 Journal J. Neuroimmunol. Section Abstract Doc Link 15885321 Disease Relevance 0.76 Pain Relevance 0.26
Both anococcygeus and retractor penis showed a similar expression of RhoA, ROKalpha, and ROKbeta at the protein level as well as the mRNA for RhoGEFs.
Gene_expression (expression) of RhoA in anococcygeus
5) Confidence 0.47 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 15857612 Disease Relevance 0 Pain Relevance 0.04
The results indicate that the RhoA/ROK-mediated Ca(2+) sensitization pathway is expressed in anococcygeus and retractor penis muscles and enhances contractions produced by receptor-dependent and independent mechanisms.
Gene_expression (expressed) of RhoA in muscles
6) Confidence 0.47 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 15857612 Disease Relevance 0 Pain Relevance 0.09
They were transfected with recombinant adenoviruses to express constitutive active (CA) or dominant negative (DN) forms of RhoA, Rac1, or Cdc42 under the control of the CAG promoter, along with marker genes (?
Gene_expression (express) of RhoA
7) Confidence 0.36 Published 2009 Journal Mol Brain Section Body Doc Link PMC2789715 Disease Relevance 0.28 Pain Relevance 0.23
Recombinant adenoviruses expressing constitutive active (CA) or dominant negative (DN) forms of Cdc42, Rac1 or RhoA, together with marker genes (lacZ for CA and GFP for DN) under the control of a CAG promoter were constructed as previously described using Adenovirus Expression Vector Kit (Code 6150: TaKaRa New York, NY) [58].
Gene_expression (expressing) of RhoA
8) Confidence 0.32 Published 2009 Journal Mol Brain Section Body Doc Link PMC2789715 Disease Relevance 0.09 Pain Relevance 0
Recombinant adenovirus-mediated expression of dominant-negative forms of RhoA and Rac1 increased the survival of transplanted cells more then two-fold in the intact spinal cord.
Gene_expression (expression) of RhoA in spinal cord associated with spinal cord
9) Confidence 0.28 Published 2009 Journal Mol Brain Section Body Doc Link PMC2789715 Disease Relevance 0.79 Pain Relevance 0.25
Expression of RhoA by inflammatory macrophages and T cells in rat experimental autoimmune neuritis.
Gene_expression (Expression) of RhoA in inflammatory macrophages associated with inflammation, experimental autoimmune neuritis and neuritis
10) Confidence 0.26 Published 2007 Journal J. Cell. Mol. Med. Section Title Doc Link 17367505 Disease Relevance 0.76 Pain Relevance 0.83
Transient expression of myc-G14V-RhoA, a dominant-active mutant of RhoA [79] was achieved by transfection using the Nucleofector II device (Lonza, Basel) and an optimized protocol for mouse hepatocytes.
Gene_expression (expression) of RhoA (G14V) in hepatocytes
11) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2975642 Disease Relevance 0.09 Pain Relevance 0.05
On the other hand, transfecting cells with myc-G14V-RhoA, the constitutively active form of RhoA exhibiting remarkably reduced intrinsic GTPase activity and unresponsiveness to RhoA GTPase-activating protein [34], resulted in random oscillations of peroxisomes that were indistinguishable from those observed after Nocodazole treatment (Fig. 1B).
Gene_expression (transfecting) of RhoA
12) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2975642 Disease Relevance 0 Pain Relevance 0
In this study, RhoA expression has been investigated in the dorsal/ventral roots of EAN rats by immunohistochemistry.
Gene_expression (expression) of RhoA in dorsal associated with neuritis
13) Confidence 0.23 Published 2007 Journal J. Cell. Mol. Med. Section Abstract Doc Link 17367505 Disease Relevance 0.75 Pain Relevance 0.66

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