INT109869

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Context Info
Confidence 0.16
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.45
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ugt2b)
Anatomy Link Frequency
liver 1
Ugt2b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 167 99.16 Very High Very High Very High
Dopamine 1 49.88 Quite Low
cINOD 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
halothane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 19 90.72 High High
Overdose 9 86.88 High High
Liver Failure 1 85.92 High High
Stress 2 63.72 Quite High
Hepatotoxicity 5 54.72 Quite High
Apoptosis 16 50.00 Quite Low
Drug Induced Neurotoxicity 6 44.24 Quite Low
Alzheimer's Dementia 1 37.40 Quite Low
Death 46 33.92 Quite Low
Acute Liver Failure 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The compounds showed a broad range of in vivo hepatic extraction ratios (rat, 0.05-0.93; humans, 0.03-0.76) and were metabolized by hepatic P450, UDP-glucuronosyltransferase, sulfotransferase, and/or esterase.
UDP-glucuronosyltransferase Binding (metabolized) of
1) Confidence 0.16 Published 2003 Journal Drug Metab. Dispos. Section Abstract Doc Link 12695346 Disease Relevance 0 Pain Relevance 0.09
Acetaminophen is mainly metabolised, in the liver, via conjugation by sulphotransferase and UDP-glucuronosyltransferase and then excreted, but a small fraction of it is metabolised by CYP2E1 [7], [35].
UDP-glucuronosyltransferase Binding (conjugation) of in liver associated with paracetamol
2) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000821 Disease Relevance 0.45 Pain Relevance 1.03

General Comments

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