INT109881

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Context Info
Confidence 0.47
First Reported 2003
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 12.97
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (F8) oxidoreductase activity (F8) extracellular region (F8)
cell adhesion (F8)
Anatomy Link Frequency
endothelial cells 4
plasma 2
platelet 2
foramen ovale 2
F8 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1 100.00 Very High Very High Very High
Inflammatory response 2 99.22 Very High Very High Very High
cva 91 98.00 Very High Very High Very High
epidural 6 96.96 Very High Very High Very High
analgesia 6 96.60 Very High Very High Very High
Inflammation 10 94.16 High High
Migraine 1 78.64 Quite High
headache 4 46.64 Quite Low
depression 2 13.76 Low Low
corticosteroid 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperhomocysteinemia 2 99.88 Very High Very High Very High
Vasculitis 2 99.86 Very High Very High Very High
Psychosis 46 99.84 Very High Very High Very High
Systemic Lupus Erythematosus 6 99.12 Very High Very High Very High
INFLAMMATION 12 99.02 Very High Very High Very High
Adhesions 3 98.92 Very High Very High Very High
Leukemia 2 98.80 Very High Very High Very High
Disease 38 98.48 Very High Very High Very High
Congenital Anomalies 6 98.08 Very High Very High Very High
Thrombosis 171 98.02 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, in type 1, the increased synthesis of von Willebrand factor (vWF) and factor VIII (FVIII:C) during pregnancy can lead to a correction of biological abnormalities and may allow epidural analgesia to be performed for delivery.
Positive_regulation (increased) of Gene_expression (synthesis) of factor VIII associated with congenital anomalies, epidural and analgesia
1) Confidence 0.47 Published 2007 Journal Int J Obstet Anesth Section Abstract Doc Link 17509867 Disease Relevance 0.27 Pain Relevance 0.40
However, in type 1, the increased synthesis of von Willebrand factor (vWF) and factor VIII (FVIII:C) during pregnancy can lead to a correction of biological abnormalities and may allow epidural analgesia to be performed for delivery.
Positive_regulation (increased) of Gene_expression (synthesis) of FVIII associated with congenital anomalies, epidural and analgesia
2) Confidence 0.34 Published 2007 Journal Int J Obstet Anesth Section Abstract Doc Link 17509867 Disease Relevance 0.27 Pain Relevance 0.40
In a second trial, a B-domain-deleted cDNA was expressed from a moloney murine leukaemia virus-based (retroviral) vector [169], which only produced levels of FVIII expression above 1% sporadically, concluding that efficient retroviral transduction would probably require higher doses and some degree of mitotic induction.
Positive_regulation (levels) of Gene_expression (expression) of FVIII associated with leukemia
3) Confidence 0.29 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.16 Pain Relevance 0
Acute inflammatory responses associated with vascular injury often result in elevated cytokines, platelet count, fibrinogen, and VWF-Factor VIII levels over the normal limit.
Positive_regulation (result) of Gene_expression (levels) of Factor VIII in platelet associated with inflammatory response, vasculitis and cytokine
4) Confidence 0.13 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2876854 Disease Relevance 1.20 Pain Relevance 0.27
The elevated VWF-Ag and Factor VIII levels seen in our patient also provide evidence for endothelial cell perturbation in SS.
Positive_regulation (elevated) of Gene_expression (levels) of Factor VIII in endothelial cell associated with syndrome
5) Confidence 0.05 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2267466 Disease Relevance 1.49 Pain Relevance 0
We found a trend (median 148% versus 110%, mean 160 ± 72.5 versus 123 ± 62.5; P = 0.062) of increased plasma levels of factor VIII in psychotic patients as compared with healthy volunteers.


Positive_regulation (increased) of Gene_expression (levels) of factor VIII in plasma associated with psychosis
6) Confidence 0.04 Published 2011 Journal BMC Psychiatry Section Abstract Doc Link PMC3022806 Disease Relevance 1.06 Pain Relevance 0.10
We found a trend (t = 1,911; df = 46; p = 0,062; Student's T-test) towards increased levels of factor VIII in patients with psychosis as compared with healthy volunteers.
Positive_regulation (increased) of Gene_expression (levels) of factor VIII associated with psychosis
7) Confidence 0.04 Published 2011 Journal BMC Psychiatry Section Body Doc Link PMC3022806 Disease Relevance 0.81 Pain Relevance 0.11
Current theories suggest that CMV induces thrombosis by enhancing platelet and leukocyte adhesion to infected endothelial cells, or, alternatively, by increasing the circulatory levels of Factor VIII.
Positive_regulation (increasing) of Gene_expression (levels) of Factor VIII in endothelial cells associated with cytomegalovirus infection, adhesions and thrombosis
8) Confidence 0.01 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2615038 Disease Relevance 2.42 Pain Relevance 0
We assessed the occurrence of several prothrombotic states (factor V Leiden, prothrombin G20210A, deficiencies in protein S, protein C and antithrombin, lupus anticoagulant, anticardiolipin antibodies, elevated factor VIII, resistance to activated protein C) and classical risk factors for venous thrombosis in 57 adult patients with cryptogenic stroke and patent foramen ovale and in 104 matched controls.
Positive_regulation (elevated) of Gene_expression (resistance) of factor VIII in foramen ovale associated with patent foramen ovale, stroke, thrombosis related under development and systemic lupus erythematosus
9) Confidence 0.01 Published 2003 Journal Blood Coagul. Fibrinolysis Section Abstract Doc Link 12695749 Disease Relevance 1.30 Pain Relevance 0.16
Factor V Leiden, RR = 50, Antithrombin deficiency, RR = 25, Protein C and S deficiency, RR = 10); acquired conditions (e.g. major surgery or trauma, RR = 5–200; history of venous thromboembolism, RR = 50); and hereditary, environmental, or idiopathic conditions (e.g. hyperhomocysteinemia, and elevated levels of Factor VIII, RR = 3: elevated levels of Factor IX, RR = 2.3).
Positive_regulation (elevated) of Gene_expression (levels) of Factor VIII associated with injury, cva, thrombosis related under development and hyperhomocysteinemia
10) Confidence 0.01 Published 2004 Journal Thromb J Section Body Doc Link PMC526763 Disease Relevance 1.52 Pain Relevance 0.05
Factor V Leiden, RR = 50, Antithrombin deficiency, RR = 25, Protein C and S deficiency, RR = 10); acquired conditions (e.g. major surgery or trauma, RR = 5–200; history of venous thromboembolism, RR = 50); and hereditary, environmental, or idiopathic conditions (e.g. hyperhomocysteinemia, and elevated levels of Factor VIII, RR = 3: elevated levels of Factor IX, RR = 2.3).
Positive_regulation (elevated) of Gene_expression (levels) of Factor VIII associated with injury, cva, thrombosis related under development and hyperhomocysteinemia
11) Confidence 0.01 Published 2004 Journal Thromb J Section Body Doc Link PMC526763 Disease Relevance 1.58 Pain Relevance 0.05
Hypercoagulable states via multiple mechanisms including factor V Leiden and prothrombin mutations, increased levels of factor VIII, IX and XI, deficiencies of antithrombin III, proteins C and S as well as a variety of medical and surgical comorbidities may confer increased risk of CVST.
Positive_regulation (increased) of Gene_expression (levels) of factor VIII associated with intracranial sinus thrombosis
12) Confidence 0.01 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2413258 Disease Relevance 0.88 Pain Relevance 0

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