INT109906

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Context Info
Confidence 0.54
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 1.68
Pain Relevance 2.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MAPK1) mitochondrion (MAPK1) Golgi apparatus (MAPK1)
DNA binding (MAPK1) protein complex (MAPK1) response to stress (MAPK1)
Anatomy Link Frequency
monocytes 3
epithelial cells 1
astrocytes 1
MAPK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 24 98.20 Very High Very High Very High
corticosteroid 16 97.56 Very High Very High Very High
dexamethasone 28 96.80 Very High Very High Very High
metalloproteinase 313 94.88 High High
COX-2 inhibitor 6 89.60 High High
antagonist 10 85.84 High High
Inflammation 107 75.92 Quite High
COX2 1 71.28 Quite High
Inflammatory mediators 12 65.04 Quite High
cINOD 17 64.80 Quite High
Disease Link Frequency Relevance Heat
Retinal Diseases 3 93.32 High High
Osteoarthritis 4 89.12 High High
Cancer 75 84.00 Quite High
Reprotox - General 1 37 77.52 Quite High
Colon Cancer 43 76.96 Quite High
INFLAMMATION 140 75.92 Quite High
Sprains And Strains 27 74.20 Quite High
Apoptosis 74 70.76 Quite High
Melanoma 5 67.80 Quite High
Inflammatory Breast Neoplasms 8 57.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B p65 and p50 were significantly enriched at predicted binding elements on promoter regions of MAPK1, CDK5, SLC2A1, IGF1R, TUBB, BRAF, DROSHA, ITGB4, MT1X and MT1E, when compared with the no antibody ChIP-qPCR control and the nonspecific occupancy at ACTB (Figure 3B, C and 3D).
Localization (occupancy) of MAPK1
1) Confidence 0.54 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.26 Pain Relevance 0
This study investigates chemokine secretion induced by co-culture of hRPE cells and monocytes and illustrates the roles of p38 kinase, ERK, JNK/SAPK and NF-kappaB-inducing kinase signaling pathways for hRPE IL-8 and MCP-1 secretion induced in hRPE by co-culture with monocytes.
Localization (secretion) of ERK in monocytes associated with chemokine
2) Confidence 0.49 Published 2003 Journal Exp. Eye Res. Section Abstract Doc Link 12697421 Disease Relevance 0.09 Pain Relevance 0.12
Stimulation of hRPE cells by monocytes resulted in prominent increases in p38, ERK1/2 and JNK/SAPK phosphorolation, IkappaBalpha degradation, and NF-kappaB nuclear translocation.
Localization (translocation) of p38 in monocytes
3) Confidence 0.49 Published 2003 Journal Exp. Eye Res. Section Abstract Doc Link 12697421 Disease Relevance 0.14 Pain Relevance 0.25
This study investigates chemokine secretion induced by co-culture of hRPE cells and monocytes and illustrates the roles of p38 kinase, ERK, JNK/SAPK and NF-kappaB-inducing kinase signaling pathways for hRPE IL-8 and MCP-1 secretion induced in hRPE by co-culture with monocytes.
Localization (secretion) of p38 in monocytes associated with chemokine
4) Confidence 0.49 Published 2003 Journal Exp. Eye Res. Section Abstract Doc Link 12697421 Disease Relevance 0.09 Pain Relevance 0.12
Protein expression was measured by 4°C overnight immunoblotting with diluted antibodies: extracellular signal-regulated kinase 2 (mouse monoclonal ERK2, 1:1000; Santa Cruz Biotechnology, Santa Cruz, CA), phosphorylated ERK1/2 (mouse monoclonal pERK, 1:500; Santa Cruz Biotechnology), COX-2 (goat polyclonal, 1:500; Santa Cruz Biotechnology) iNOS (rabbit polyclonal, 1:500; Santa Cruz Biotechnology) and phosphorylated CREB (rabbit polyclonal, 1:1000; AbCam, Cambridge, MA).
Localization (1:1000) of ERK2
5) Confidence 0.45 Published 2005 Journal Cell Commun Signal Section Body Doc Link PMC1198236 Disease Relevance 0 Pain Relevance 0
ASMC were pre-incubated for 1 hour with specific inhibitors for ERK (PD98059), JNK (SP600125), p38 MAPK (SB203580) or for PI3-K (wortmannin and LY294002), or with the corticosteroid, dexamethasone, and then co-treated with IL-1?
Localization (for) of p38 MAPK associated with corticosteroid and dexamethasone
6) Confidence 0.42 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0 Pain Relevance 0.58
ASMC were pre-incubated for 1 hour with specific inhibitors for ERK (PD98059), JNK (SP600125), p38 MAPK (SB203580) or for PI3-K (wortmannin and LY294002), or with the corticosteroid, dexamethasone, and then co-treated with IL-1?
Localization (for) of ERK associated with corticosteroid and dexamethasone
7) Confidence 0.42 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0 Pain Relevance 0.58
Indeed, our recent studies have shown that activation of the p38, ERK, and JNK MAP kinases is required for the chondrogenic induction and maintenance of TGF-?
Localization (kinases) of ERK
8) Confidence 0.18 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154434 Disease Relevance 0.23 Pain Relevance 0
Similarly, COX-2-specific inhibitors reduce angiogenesis by inhibiting mitogen activated protein kinase (extracellular signal regulated kinase [ERK]2) activity and by interfering with nuclear translocation of ERK [14].
Localization (translocation) of ERK
9) Confidence 0.18 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1797025 Disease Relevance 0.34 Pain Relevance 0.04
The ERK signalling pathway is activated by V. parahaemolyticus and leads to IL-8 secretion by intestinal epithelial cells
Localization (leads) of ERK in epithelial cells
10) Confidence 0.13 Published 2010 Journal BMC Microbiol Section Body Doc Link PMC3022711 Disease Relevance 0.20 Pain Relevance 0
Preparation of RV homogenates for ERK 1/2, JNK, phospho PKC ?
Localization (Preparation) of ERK
11) Confidence 0.09 Published 2005 Journal BMC Physiol Section Body Doc Link PMC1142330 Disease Relevance 0.05 Pain Relevance 0.03
cascades (Erk, Jnk, and p38 MAP kinase) in astrocytes by a PPAR-?
Localization (kinase) of Erk in astrocytes
12) Confidence 0.02 Published 2008 Journal PPAR Research Section Body Doc Link PMC2367430 Disease Relevance 0.27 Pain Relevance 0.30

General Comments

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