INT109908

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Context Info
Confidence 0.73
First Reported 2003
Last Reported 2009
Negated 0
Speculated 2
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 3.86
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPK8) nucleoplasm (MAPK8) mitochondrion (MAPK8)
nucleus (MAPK8) response to stress (MAPK8) cytoplasm (MAPK8)
Anatomy Link Frequency
monocytes 2
Plaques 2
astrocytes 1
nucleus 1
MAPK8 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 17 97.86 Very High Very High Very High
corticosteroid 8 97.56 Very High Very High Very High
Kinase C 6 96.80 Very High Very High Very High
dexamethasone 18 95.96 Very High Very High Very High
metalloproteinase 162 94.88 High High
Osteoarthritis 176 93.32 High High
Hippocampus 2 92.96 High High
Inflammation 147 92.68 High High
Inflammatory mediators 10 88.72 High High
Inflammatory response 11 86.16 High High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 76 100.00 Very High Very High Very High
Amyloid Plaque 70 100.00 Very High Very High Very High
Stress 44 99.98 Very High Very High Very High
Apoptosis 22 96.88 Very High Very High Very High
Osteoarthritis 184 93.32 High High
INFLAMMATION 179 92.68 High High
Retinal Diseases 2 92.64 High High
Drug Induced Neurotoxicity 23 89.52 High High
Dysesthesia 13 77.92 Quite High
Ganglion Cysts 2 75.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stimulation of hRPE cells by monocytes resulted in prominent increases in p38, ERK1/2 and JNK/SAPK phosphorolation, IkappaBalpha degradation, and NF-kappaB nuclear translocation.
Localization (translocation) of JNK in monocytes
1) Confidence 0.73 Published 2003 Journal Exp. Eye Res. Section Abstract Doc Link 12697421 Disease Relevance 0.14 Pain Relevance 0.25
This study investigates chemokine secretion induced by co-culture of hRPE cells and monocytes and illustrates the roles of p38 kinase, ERK, JNK/SAPK and NF-kappaB-inducing kinase signaling pathways for hRPE IL-8 and MCP-1 secretion induced in hRPE by co-culture with monocytes.
Localization (secretion) of JNK in monocytes associated with chemokine
2) Confidence 0.73 Published 2003 Journal Exp. Eye Res. Section Abstract Doc Link 12697421 Disease Relevance 0.09 Pain Relevance 0.12
JNK Is Activated in Brain Areas Surrounding Senile Plaques of AD Animal Model—To investigate the relation between JNK and A?
Spec (investigate) Localization (relation) of JNK in Plaques associated with alzheimer's dementia and amyloid plaque
3) Confidence 0.69 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.56 Pain Relevance 0.05
JNK Is Activated in Brain Areas Surrounding Senile Plaques of AD Animal Model—To investigate the relation between JNK and A?
Spec (investigate) Localization (relation) of JNK in Plaques associated with alzheimer's dementia and amyloid plaque
4) Confidence 0.69 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.57 Pain Relevance 0.05
ASMC were pre-incubated for 1 hour with specific inhibitors for ERK (PD98059), JNK (SP600125), p38 MAPK (SB203580) or for PI3-K (wortmannin and LY294002), or with the corticosteroid, dexamethasone, and then co-treated with IL-1?
Localization (for) of JNK associated with corticosteroid and dexamethasone
5) Confidence 0.42 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0 Pain Relevance 0.58
Downstream nuclear events in JNK, p38, and NF-?
Localization (events) of JNK
6) Confidence 0.33 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 0 Pain Relevance 0
These findings support the hypothesis that the JNK and p38 MAPKs as well as the NF-?
Localization (support) of JNK
7) Confidence 0.31 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656251 Disease Relevance 0.25 Pain Relevance 0.13
Indeed, our recent studies have shown that activation of the p38, ERK, and JNK MAP kinases is required for the chondrogenic induction and maintenance of TGF-?
Localization (kinases) of JNK
8) Confidence 0.21 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154434 Disease Relevance 0.23 Pain Relevance 0
B, while leptin-induced PGE2 production was reduced by inhibitors of JNK, p38, and Erk1/2 MAPkinases and transcription factor NF-?
Localization (/) of JNK
9) Confidence 0.17 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.47 Pain Relevance 0.43
Oxidative stress releases GSTP1 from JNK, which in turn activates the expression of GSTP1 and other genes involved in apoptosis and cytoprotection [39].
Localization (releases) of JNK associated with stress and apoptosis
10) Confidence 0.12 Published 2007 Journal J Transl Med Section Body Doc Link PMC2245909 Disease Relevance 0.88 Pain Relevance 0.10
cascades (Erk, Jnk, and p38 MAP kinase) in astrocytes by a PPAR-?
Localization (kinase) of Jnk in astrocytes
11) Confidence 0.06 Published 2008 Journal PPAR Research Section Body Doc Link PMC2367430 Disease Relevance 0.27 Pain Relevance 0.30
It has been demonstrated that during reperfusion, oxidative stress leads to activation and translocation of JNK to the nucleus, where phosphorylation of transcription factors, such as c-Jun occurs.


Localization (translocation) of JNK in nucleus associated with stress
12) Confidence 0.05 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.40 Pain Relevance 0.15

General Comments

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