INT109910

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Context Info
Confidence 0.74
First Reported 2002
Last Reported 2010
Negated 4
Speculated 3
Reported most in Body
Documents 104
Total Number 128
Disease Relevance 76.10
Pain Relevance 43.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CCL16) extracellular region (CCL16) cell-cell signaling (CCL16)
Anatomy Link Frequency
lens capsules 9
capsules 7
skin 7
endometrium 6
monocytes 5
CCL16 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 4476 100.00 Very High Very High Very High
cytokine 643 100.00 Very High Very High Very High
rheumatoid arthritis 3746 99.90 Very High Very High Very High
Inflammation 1161 99.74 Very High Very High Very High
Morphine 222 99.72 Very High Very High Very High
Central nervous system 268 99.58 Very High Very High Very High
Inflammatory response 43 99.56 Very High Very High Very High
Multiple sclerosis 309 99.48 Very High Very High Very High
endometriosis 1612 99.44 Very High Very High Very High
Arthritis 53 98.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 562 100.00 Very High Very High Very High
Epstein-barr Virus 10 100.00 Very High Very High Very High
Syndrome 87 99.92 Very High Very High Very High
Rheumatoid Arthritis 3748 99.90 Very High Very High Very High
Arthritis 13 99.74 Very High Very High Very High
Anaplastic Astrocytoma 4 99.64 Very High Very High Very High
Central Nervous System Disease 240 99.58 Very High Very High Very High
Demyelinating Disease 399 99.48 Very High Very High Very High
Capsule Opacification 2187 99.46 Very High Very High Very High
Endometriosis 1863 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overall there was a significant elevation in eutopic endometrial glandular CCL16 expression in women with endometriosis compared to controls (n = 3; P = 0.049).
Gene_expression (expression) of CCL16 associated with endometriosis
1) Confidence 0.74 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 0.53 Pain Relevance 0.30
These combined data clearly show that the expression of CCL16 and CCL21 is disturbed at least in some patients with endometriosis.
Gene_expression (expression) of CCL16 associated with endometriosis
2) Confidence 0.74 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 0.68 Pain Relevance 0.48
CCL16 protein was detected in the glandular epithelium of all but one of the 32 tissues examined and CCL21 protein was evident in glands in all tissues.
Gene_expression (detected) of CCL16 protein in glands
3) Confidence 0.74 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 0.56 Pain Relevance 0.44
The data from this pathway-specific gene array thus provides new evidence for the broad dysregulation of chemokine expression in both eutopic endometrial epithelium and ectopic lesions of women with endometriosis.
Gene_expression (expression) of chemokine in epithelium associated with endometriosis and chemokine
4) Confidence 0.64 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 1.03 Pain Relevance 0.63
To provide a global chemokine expression profile in eutopic endometrium from normal women and endometriosis patients, and to overcome patient to patient variability, total RNA extracted from LCM glandular epithelial cells was pooled from 4 individuals in each group (Table 1).
Gene_expression (expression) of chemokine in endometrium associated with endometriosis and chemokine
5) Confidence 0.64 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 0.24 Pain Relevance 0.21
Of 77 genes profiled on the cDNA gene arrays, expression of 22 chemokine and receptors were reproducibly (two separate runs) upregulated in pooled endometrium from women with endometriosis compared with controls (Table 2).
Gene_expression (expression) of chemokine in endometrium associated with endometriosis and chemokine
6) Confidence 0.64 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 0.31 Pain Relevance 0.25
For this study, selected tissue samples, derived only from women in the mid-secretory phase (POD 6–10) were assessed for chemokine expression.
Gene_expression (expression) of chemokine associated with chemokine
7) Confidence 0.64 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 0.49 Pain Relevance 0.21
However, the level of chemokine expression did not correlate with the severity of the endometriosis.
Gene_expression (expression) of chemokine associated with endometriosis and chemokine
8) Confidence 0.64 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 1.27 Pain Relevance 0.55
As there are no reports of chemokine expression profiling in endometriosis, the present study is the first to provide a comprehensive list of potential candidate chemokines and receptors in laser-captured glandular epithelium in eutopic endometrium from women with endometriosis.
Gene_expression (expression) of chemokine in endometrium associated with endometriosis and chemokine
9) Confidence 0.64 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 0.47 Pain Relevance 0.43
Real-time PCR verified that there were differences in the mRNA encoding CCL16 and CCL21, the two chemokines selected for further study, but that there was considerable heterogeneity in expression in individual endometriosis subjects.
Gene_expression (expression) of CCL16 associated with endometriosis and chemokine
10) Confidence 0.64 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 0.55 Pain Relevance 0.44
CCL21 mRNA was more abundant than that of CCL16 and was markedly elevated in eutopic glands from one endometriosis patient (mean, 0.61 fg/pg 18S RNA) (Figure 2B).
Gene_expression (abundant) of CCL16 in glands associated with endometriosis
11) Confidence 0.64 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 0.61 Pain Relevance 0.37
The invasive trophoblast and the eutopic endometrium strongly express chemokine receptors (CCR1, CCR10, CCR5, CCR7, CXCR4, CXCR6 and XCR) and chemokines contribute to the positioning, adhesion and migration of trophoblast [55-58].
Gene_expression (express) of chemokine in endometrium associated with chemokine and adhesions
12) Confidence 0.57 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 1.14 Pain Relevance 0.63
Immunoreactive CCL16 and CCL21 were predominantly confined to glands in eutopic and ectopic endometrium: leukocytes also stained.
Gene_expression (confined) of CCL16 in endometrium
13) Confidence 0.57 Published 2007 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1884154 Disease Relevance 0.61 Pain Relevance 0.49
For the further verification of gene array and real time RT-PCR data, frozen sections from 3 of the 4 same endometriosis patients and control subjects, along with tissue sections from an additional 8 normal and 7 endometriosis subjects, were used for the immunohistochemical comparison of chemokine (CCL16 and CCL21) protein expression (n = 12 and 10 respectively per group).
Gene_expression (expression) of CCL16 associated with chemokine and endometriosis
14) Confidence 0.57 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 0.38 Pain Relevance 0.19
In laser captured glands from control subjects, CCL16 and CCL21 mRNA were uniformly undetectable or at low levels.
Gene_expression (undetectable) of CCL16 in glands
15) Confidence 0.57 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 0.55 Pain Relevance 0.37
Immunoreactive CCL16 was overall higher in glands in ectopic vs. eutopic endometrium from the same woman (P < 0.05).
Gene_expression (higher) of CCL16 in glands
16) Confidence 0.57 Published 2007 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1884154 Disease Relevance 0.57 Pain Relevance 0.46
Gene profiling was conducted using the GeArray Q Series Human Chemokine and Receptor Gene Array (SuperArray Bioscience Corp., Bethesda, USA) consisting of 77 chemokine and chemokine receptor cDNA probes, printed in quadruplicate on a nylon membrane.
Gene_expression (using) of Chemokine associated with chemokine
17) Confidence 0.56 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 0.14 Pain Relevance 0.19
Gene profiling was conducted using the GeArray Q Series Human Chemokine and Receptor Gene Array (SuperArray Bioscience Corp., Bethesda, USA) consisting of 77 chemokine and chemokine receptor cDNA probes, printed in quadruplicate on a nylon membrane.
Gene_expression (using) of chemokine associated with chemokine
18) Confidence 0.56 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 0.15 Pain Relevance 0.19
No significant differences were detected for either CCL16 or CCL21 between mean glandular staining intensity in endometrium from normal women compared with eutopic endometrium from women with endometriosis (Figure 3).
Neg (No) Gene_expression (detected) of CCL16 in endometrium associated with endometriosis
19) Confidence 0.56 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 0.53 Pain Relevance 0.45
Aberrant chemokine expression in the uterine lumen may interfere with blastocyst implantation and hence provide one rationale for the infertility that is often associated with endometriosis.
Gene_expression (expression) of chemokine in lumen associated with endometriosis, chemokine and reprotox - general 3
20) Confidence 0.50 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 1.14 Pain Relevance 0.68

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