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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.56
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (EPHB2)
Anatomy Link Frequency
monocytes 2
EPHB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 12 93.76 High High
b2 receptor 3 91.92 High High
chemokine 5 84.48 Quite High
Pain 1 66.68 Quite High
cINOD 1 64.80 Quite High
Inflammation 1 63.80 Quite High
dexamethasone 4 62.88 Quite High
Disease Link Frequency Relevance Heat
Retinal Diseases 1 80.44 Quite High
Breast Cancer 1 78.60 Quite High
Malignant Neoplastic Disease 1 74.64 Quite High
Pressure And Volume Under Development 1 67.16 Quite High
Pain 1 66.68 Quite High
Increased Venous Pressure Under Development 1 66.44 Quite High
INFLAMMATION 2 64.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stimulation of hRPE cells by monocytes resulted in prominent increases in p38, ERK1/2 and JNK/SAPK phosphorolation, IkappaBalpha degradation, and NF-kappaB nuclear translocation.
Positive_regulation (increases) of Localization (translocation) of ERK in monocytes
1) Confidence 0.49 Published 2003 Journal Exp. Eye Res. Section Abstract Doc Link 12697421 Disease Relevance 0.14 Pain Relevance 0.25
Intracellular effects of B2 stimulation were the following: (a) the increase of free intracellular Ca(2+) concentration by a mechanism dependent upon the phospholipase C (PLC) activity; (b) the cytosol-to-membrane translocation of conventional (PKC)-alpha and -beta isozymes, novel PKC-delta, -epsilon, and -eta isozymes; (c) the phosphorylation of the extracellular-regulated kinase 1 and 2 (ERK1/2); and (d) the stimulation of the expression of c-Fos protein.
Positive_regulation (upon) of Localization (translocation) of ERK
2) Confidence 0.49 Published 2004 Journal J. Cell. Physiol. Section Abstract Doc Link 15281091 Disease Relevance 0.42 Pain Relevance 0.52

General Comments

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