INT109915

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Context Info
Confidence 0.86
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.92
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPK8) nucleoplasm (MAPK8) mitochondrion (MAPK8)
nucleus (MAPK8) response to stress (MAPK8) cytoplasm (MAPK8)
Anatomy Link Frequency
monocytes 1
MAPK8 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 75 89.96 High High
chemokine 5 82.36 Quite High
cINOD 1 61.84 Quite High
Inflammation 35 61.68 Quite High
dexamethasone 4 59.92 Quite High
Eae 3 55.48 Quite High
cerebral cortex 1 36.96 Quite Low
Hippocampus 1 36.16 Quite Low
imagery 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 68 99.00 Very High Very High Very High
Stress 102 98.28 Very High Very High Very High
Shock 1 96.84 Very High Very High Very High
Disease 193 88.28 High High
Apoptosis 24 79.68 Quite High
Retinal Diseases 1 79.28 Quite High
Toxicity 1 73.08 Quite High
Targeted Disruption 1 65.92 Quite High
INFLAMMATION 36 61.68 Quite High
Down Syndrome 16 38.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stimulation of hRPE cells by monocytes resulted in prominent increases in p38, ERK1/2 and JNK/SAPK phosphorolation, IkappaBalpha degradation, and NF-kappaB nuclear translocation.
Protein_catabolism (degradation) of JNK in monocytes
1) Confidence 0.86 Published 2003 Journal Exp. Eye Res. Section Abstract Doc Link 12697421 Disease Relevance 0.14 Pain Relevance 0.24
Upon dual Tyr-Thr phosphorylation JNK and p38 are activated under environmental stresses such as UV radiation, heat shock, and oxidative stress, while ERK is activated by mitogens and growth factors to promote cell survival, differentiation and cell cycle regulation [9], [24].
Protein_catabolism (dual) of JNK associated with stress and shock
2) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 1.62 Pain Relevance 0.10
p42/44 MAP Kinase and JNK pathways do not influence LPS induced TNFalpha synthesis
Protein_catabolism (pathways) of JNK
3) Confidence 0.14 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2819999 Disease Relevance 0.16 Pain Relevance 0

General Comments

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