INT109916

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Context Info
Confidence 0.45
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 2.28
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAP2K6) nucleoplasm (MAP2K6) signal transduction (MAP2K6)
cytoskeleton (MAP2K6) nucleus (MAP2K6) response to stress (MAP2K6)
Anatomy Link Frequency
chondrocytes 6
MAP2K6 (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 4 100.00 Very High Very High Very High
Osteoarthritis 412 99.60 Very High Very High Very High
cINOD 1 89.88 High High
cytokine 32 87.60 High High
chemokine 5 79.48 Quite High
Arthritis 32 69.36 Quite High
rheumatoid arthritis 16 57.60 Quite High
Inflammation 64 50.32 Quite High
Pain 8 44.08 Quite Low
metalloproteinase 24 25.64 Quite Low
Disease Link Frequency Relevance Heat
Osteoarthritis 416 99.60 Very High Very High Very High
INFLAMMATION 57 89.64 High High
Targeted Disruption 12 89.60 High High
Experimental Arthritis 4 69.36 Quite High
Arthritis 36 66.80 Quite High
Stress 4 65.08 Quite High
Rheumatoid Arthritis 16 57.60 Quite High
Retinal Diseases 1 47.16 Quite Low
Pain 4 44.08 Quite Low
Disease 20 41.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-induced activation of MKK3 and MKK6 in human OA chondrocytes, cells were pretreated with PE (6.25 to 100 ?
Positive_regulation (induced) of Positive_regulation (activation) of MKK6 in chondrocytes associated with osteoarthritis
1) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.71 Pain Relevance 0.33
-induced activation of MKK3 and MKK6 in primary human OA chondrocytes.
Positive_regulation (induced) of Positive_regulation (activation) of MKK6 in chondrocytes associated with osteoarthritis
2) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.49 Pain Relevance 0.24
-induced activation of MKK3 and MKK6 in human OA chondrocytes
Positive_regulation (induced) of Positive_regulation (activation) of MKK6 in chondrocytes associated with osteoarthritis
3) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.60 Pain Relevance 0.30
This suggests that substrate selectivity might contribute to the distinct functional profiles of MKK activation.
Spec (might) Positive_regulation (contribute) of Positive_regulation (activation) of MKK
4) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.39 Pain Relevance 0.19
These results suggest that activation of DEX-sensitive, CSA-resistant MEK/ERK and p38 pathways, and activation of NF-kappaB, PKC, and PTK are essential for IL-8 and MCP-1 expression by hRPE cells.
Positive_regulation (essential) of Positive_regulation (activation) of MEK associated with dexamethasone
5) Confidence 0.11 Published 2003 Journal Exp. Eye Res. Section Abstract Doc Link 12697421 Disease Relevance 0.09 Pain Relevance 0.38

General Comments

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