INT109917

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Context Info
Confidence 0.66
First Reported 2003
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 17
Total Number 24
Disease Relevance 11.87
Pain Relevance 2.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CCL16) extracellular region (CCL16) cell-cell signaling (CCL16)
Anatomy Link Frequency
lens capsules 4
capsules 2
lens 2
endometrium 2
joint 2
CCL16 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 471 100.00 Very High Very High Very High
Inflammation 126 99.90 Very High Very High Very High
endometriosis 420 99.40 Very High Very High Very High
rheumatoid arthritis 7 94.92 High High
COX-2 inhibitor 83 85.04 High High
antagonist 1 74.64 Quite High
Inflammatory response 8 73.60 Quite High
cINOD 17 68.80 Quite High
Osteoarthritis 32 65.60 Quite High
cytokine 56 57.44 Quite High
Disease Link Frequency Relevance Heat
Capsule Opacification 669 100.00 Very High Very High Very High
Arthritis 2 99.90 Very High Very High Very High
Endometriosis 486 99.40 Very High Very High Very High
Apoptosis 160 99.04 Very High Very High Very High
Metastasis 7 98.72 Very High Very High Very High
INFLAMMATION 161 98.40 Very High Very High Very High
Cataract 331 98.04 Very High Very High Very High
Cancer 74 97.48 Very High Very High Very High
Autoimmune Disease 13 97.32 Very High Very High Very High
Leukemia 12 96.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overall there was a significant elevation in eutopic endometrial glandular CCL16 expression in women with endometriosis compared to controls (n = 3; P = 0.049).
Positive_regulation (elevation) of Gene_expression (expression) of CCL16 associated with endometriosis
1) Confidence 0.66 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 0.53 Pain Relevance 0.31
Of 77 genes profiled on the cDNA gene arrays, expression of 22 chemokine and receptors were reproducibly (two separate runs) upregulated in pooled endometrium from women with endometriosis compared with controls (Table 2).
Positive_regulation (upregulated) of Gene_expression (expression) of chemokine in endometrium associated with endometriosis and chemokine
2) Confidence 0.58 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 0.32 Pain Relevance 0.25
Overall there was a significant elevation in eutopic endometrial glandular CCL16 expression in women with endometriosis compared to controls (n = 3; P = 0.049).
Positive_regulation (glandular) of Gene_expression (expression) of CCL16 associated with endometriosis
3) Confidence 0.48 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 0.53 Pain Relevance 0.30
Gene profiling was conducted using the GeArray Q Series Human Chemokine and Receptor Gene Array (SuperArray Bioscience Corp., Bethesda, USA) consisting of 77 chemokine and chemokine receptor cDNA probes, printed in quadruplicate on a nylon membrane.
Positive_regulation (conducted) of Gene_expression (using) of chemokine associated with chemokine
4) Confidence 0.42 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 0.15 Pain Relevance 0.19
Gene profiling was conducted using the GeArray Q Series Human Chemokine and Receptor Gene Array (SuperArray Bioscience Corp., Bethesda, USA) consisting of 77 chemokine and chemokine receptor cDNA probes, printed in quadruplicate on a nylon membrane.
Positive_regulation (conducted) of Gene_expression (using) of Chemokine associated with chemokine
5) Confidence 0.42 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 0.14 Pain Relevance 0.19
However, elevations in expression of this normally constitutive chemokine have been reported in cases of chronic inflammation/pathology and autoimmune diseases where a role in inappropriate recruitment of naïve T-cells to non-lymphoid tissue has been proposed [47,48].
Positive_regulation (elevations) of Gene_expression (expression) of chemokine in lymphoid tissue associated with chemokine, autoimmune disease and inflammation
6) Confidence 0.39 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 1.07 Pain Relevance 0.40
These LEC were immunopositive for COX-2, PCNA, and ?
Positive_regulation (for) of Gene_expression (immunopositive) of LEC
7) Confidence 0.15 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765474 Disease Relevance 0.64 Pain Relevance 0
In chronic PCO lesions, the mechanical forces of pseudometaplastic LEC contraction, caused by expression of ?
Positive_regulation (caused) of Gene_expression (contraction) of LEC associated with capsule opacification
8) Confidence 0.15 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765474 Disease Relevance 1.25 Pain Relevance 0.03
Taken together, these results indicated COX-2 expression was upregulated in LEC undergoing EMT.


Positive_regulation (upregulated) of Gene_expression (undergoing) of LEC
9) Confidence 0.15 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765474 Disease Relevance 0.38 Pain Relevance 0
There were few LEC in lens capsules treated with 20 ?
Positive_regulation (were) of Gene_expression (were) of LEC in lens capsules
10) Confidence 0.15 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765474 Disease Relevance 0.49 Pain Relevance 0
To determine if LEC could recover the ability to undergo EMT following treatment with celecoxib or rofecoxib, we immediately treated six capsules with 20 ?
Positive_regulation (recover) of Gene_expression (recover) of LEC in capsules
11) Confidence 0.15 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765474 Disease Relevance 0.14 Pain Relevance 0
These LEC were immunopositive for COX-2, PCNA, and ?
Positive_regulation (for) of Gene_expression (These) of LEC
12) Confidence 0.15 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765474 Disease Relevance 0.64 Pain Relevance 0
Normal LEC expressed significantly lower (p<0.0145) levels of COX-2 mRNA and protein than cataractous LEC.
Positive_regulation (levels) of Gene_expression (expressed) of LEC
13) Confidence 0.15 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765474 Disease Relevance 0.36 Pain Relevance 0
Transfection of LEC with ILK-expressing constructs induces a morphologic change that resembles EMT [4].
Positive_regulation (Transfection) of Gene_expression (Transfection) of LEC
14) Confidence 0.13 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.59 Pain Relevance 0
The lens capsules contained minimal numbers of LEC on phase contrast evaluation of 7.5 ?
Positive_regulation (numbers) of Gene_expression (numbers) of LEC in lens capsules
15) Confidence 0.11 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.22 Pain Relevance 0
There was a positive correlation between concentration of AR-12 used and LEC apoptosis, as determined by decreased cell viability and increased caspase-3 expression in non-confluent LEC.
Positive_regulation (increased) of Gene_expression (expression) of LEC associated with apoptosis
16) Confidence 0.11 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.89 Pain Relevance 0.04
Postoperatively, the primary response of the remaining LEC is to undergo EMT, proliferate, and increase production of aberrant extracellular matrix proteins.
Positive_regulation (undergo) of Gene_expression (response) of LEC in extracellular matrix
17) Confidence 0.11 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.32 Pain Relevance 0
Anterior lens capsules with adherent LEC were excised from each lens for protein extraction and immediately frozen and stored at ?
Positive_regulation (adherent) of Gene_expression (adherent) of LEC in lens
18) Confidence 0.11 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.75 Pain Relevance 0
In support of this, LEC present in our ex vivo PCO model were undergoing EMT and were positive for ILK expression.
Positive_regulation (undergoing) of Gene_expression (present) of LEC associated with capsule opacification
19) Confidence 0.11 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.56 Pain Relevance 0
Our previous studies and other investigations did not find CCL21 expression by LEC in normal human skin.
Neg (not) Spec (find) Positive_regulation (find) of Gene_expression (expression) of LEC in skin
20) Confidence 0.11 Published 2004 Journal BMC Immunol Section Body Doc Link PMC419342 Disease Relevance 0.28 Pain Relevance 0.24

General Comments

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