INT10992

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Context Info
Confidence 0.76
First Reported 1992
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 32
Total Number 34
Disease Relevance 22.22
Pain Relevance 3.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PARP1) nuclear envelope (PARP1) transferase activity, transferring glycosyl groups (PARP1)
intracellular (PARP1) DNA binding (PARP1) nucleolus (PARP1)
Anatomy Link Frequency
cleavage 11
poly 3
MNCs 3
plasma 2
chondrocytes 1
PARP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 142 100.00 Very High Very High Very High
cytokine 38 100.00 Very High Very High Very High
Osteoarthritis 153 99.04 Very High Very High Very High
Pain 7 97.28 Very High Very High Very High
dexamethasone 44 96.48 Very High Very High Very High
Angina 20 96.36 Very High Very High Very High
qutenza 7 95.44 Very High Very High Very High
rheumatoid arthritis 25 92.04 High High
metalloproteinase 12 90.92 High High
antagonist 13 89.80 High High
Disease Link Frequency Relevance Heat
Apoptosis 932 100.00 Very High Very High Very High
INFLAMMATION 167 100.00 Very High Very High Very High
Injury 48 99.96 Very High Very High Very High
Death 203 99.46 Very High Very High Very High
Cancer 376 99.28 Very High Very High Very High
Breast Cancer 94 99.24 Very High Very High Very High
Osteoarthritis 167 99.04 Very High Very High Very High
Stress 128 98.66 Very High Very High Very High
Bordatella Infection 5 97.86 Very High Very High Very High
Pain 6 97.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpressed PARP-1 promotes PARP-1/NF-kappaB/DNA complex formation, thereby enhancing the expression of TNF-alpha and IL-6 in circulating MNCs of UA patients.


Gene_expression (Overexpressed) of PARP in MNCs
1) Confidence 0.76 Published 2008 Journal Arch. Med. Res. Section Body Doc Link 18996291 Disease Relevance 0 Pain Relevance 0
RESULTS: PARP activity and PARP-1 expression in circulating MNCs were increased and positively correlated with plasma TNF-alpha and IL-6, respectively, in UA patients.
Gene_expression (expression) of PARP in plasma
2) Confidence 0.76 Published 2008 Journal Arch. Med. Res. Section Body Doc Link 18996291 Disease Relevance 0.08 Pain Relevance 0
CONCLUSIONS: Activation and overexpression of PARP-1 are demonstrated in circulating MNCs of UA patients.
Gene_expression (overexpression) of PARP in MNCs
3) Confidence 0.76 Published 2008 Journal Arch. Med. Res. Section Body Doc Link 18996291 Disease Relevance 0 Pain Relevance 0
Activation and overexpression of PARP-1 in circulating mononuclear cells promote TNF-alpha and IL-6 expression in patients with unstable angina.
Gene_expression (overexpression) of PARP in mononuclear cells associated with angina
4) Confidence 0.76 Published 2008 Journal Arch. Med. Res. Section Title Doc Link 18996291 Disease Relevance 0.37 Pain Relevance 0.50
RESULTS: PARP activity and PARP-1 expression in circulating MNCs were increased and positively correlated with plasma TNF-alpha and IL-6, respectively, in UA patients.
Gene_expression (expression) of PARP in plasma
5) Confidence 0.66 Published 2008 Journal Arch. Med. Res. Section Body Doc Link 18996291 Disease Relevance 0.08 Pain Relevance 0
After the tolfenamic acid treatment for 48 h, the cleaved PARP (85 kDa) was clearly detected in the cells exposed to 75 and 100 µM of tolfenamic acid whereas the cleaved PARP was not observed in DMSO-treated KB cells.
Gene_expression (detected) of PARP
6) Confidence 0.56 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901767 Disease Relevance 0.35 Pain Relevance 0.03
The results of this study demonstrate that platycodon D mediates ROS production, and that this mediation is followed by a decrease in mitochondrial membrane potential (MMP, DJm), activation of caspase-3, and cleavage of poly (ADP-ribose) polymerase (PARP).
Gene_expression (cleavage) of PARP in poly
7) Confidence 0.46 Published 2009 Journal Biomed. Pharmacother. Section Abstract Doc Link 18804340 Disease Relevance 0.81 Pain Relevance 0.14
Furthermore, it has been shown that PARP-1 protein expression is tissue- and/ or cell-type specific [51], and there are tissue and species differences in requirements for NAD+??
Gene_expression (expression) of PARP-1
8) Confidence 0.43 Published 2010 Journal Journal of Nucleic Acids Section Body Doc Link PMC2915624 Disease Relevance 0.62 Pain Relevance 0
Notably, capsaicin blocked breast cancer cell migration in vitro and decreased by 50% the size of MDA-MB231 breast cancer tumors growing orthotopically in immunodeficient mice without noticeable drug side effects. in vivo activation of ERK was clearly decreased, as well as expression of HER-2 and cyclin D1, whereas caspase activity and PARP cleavage products were increased in tumors of drug-treated mice.
Gene_expression (products) of PARP in cleavage associated with qutenza, cancer and breast cancer
9) Confidence 0.38 Published 2010 Journal Oncogene Section Abstract Doc Link 19855437 Disease Relevance 0.90 Pain Relevance 0.47
Moreover, our data are consistent with prior observations suggesting that RHOB, a member of the Rho GTP-binding protein, is overexpressed in OA [17], [18] and the positive association in the expression levels of RHOB and PARP-1 [19].
Gene_expression (levels) of PARP-1 associated with osteoarthritis
10) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012157 Disease Relevance 1.08 Pain Relevance 0.47
Moreover, our data are consistent with prior observations suggesting that RHOB, a member of the Rho GTP-binding protein, is overexpressed in OA [17], [18] and the positive association in the expression levels of RHOB and PARP-1 [19].
Gene_expression (expression) of PARP-1 associated with osteoarthritis
11) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012157 Disease Relevance 1.09 Pain Relevance 0.47
m and release of Cyto c were observed in NCTD-treated cells, resulting in caspase-9 and caspase-3 activation and PARP cleavage and, finally, apoptosis.
Gene_expression (cleavage) of PARP in cleavage associated with apoptosis
12) Confidence 0.33 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2987898 Disease Relevance 0.76 Pain Relevance 0
On molecular level, synergistic effects on apoptosis induction upon combined treatment were reflected by increased cleavage of the caspase-3 substrate PARP.
Gene_expression (cleavage) of PARP in cleavage associated with apoptosis
13) Confidence 0.32 Published 2006 Journal Radiat Oncol Section Body Doc Link PMC1475859 Disease Relevance 1.26 Pain Relevance 0
M ErPC led to appearance of the cleaved PARP fragment (89 kDa), indicative for caspase-3 activation.
Gene_expression (appearance) of PARP fragment
14) Confidence 0.32 Published 2006 Journal Radiat Oncol Section Body Doc Link PMC1475859 Disease Relevance 0.97 Pain Relevance 0
Furthermore, we observed that resveratrol as well as ALLN inhibited IL-1beta-induced apoptosis, caspase-3 activation and PARP cleavage in human articular chondrocytes.
Gene_expression (cleavage) of PARP in chondrocytes associated with apoptosis
15) Confidence 0.30 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18606398 Disease Relevance 0.86 Pain Relevance 0.29
Western blot analysis was used to evaluate the level of Cyto-C, Bcl-2, Bax, Bid, caspase 3, -9, -8 and PARP expression

Results

Gene_expression (expression) of PARP
16) Confidence 0.29 Published 2010 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC2987898 Disease Relevance 0.64 Pain Relevance 0
M) that increased PARP cleavage (Figure 5a).
Gene_expression (cleavage) of PARP in cleavage
17) Confidence 0.24 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0 Pain Relevance 0.04
In contrast, from 2 h onwards, cleavage of the PARP was reduced in U2OS-h-GAAP compared to that in U2OS-neo cells (Figure 6D).
Gene_expression (cleavage) of PARP in cleavage
18) Confidence 0.23 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1803007 Disease Relevance 0.53 Pain Relevance 0
In case of severe DNA injury, overactivation of PARP-1 depletes the cellular stores of NAD+, an essential cofactor in the glycolytic pathway, the tricarboxylic acid cycle, and the mitochondrial electron transport chain.
Gene_expression (overactivation) of PARP associated with injury
19) Confidence 0.22 Published 2008 Journal Interdisciplinary Toxicology Section Body Doc Link PMC2993477 Disease Relevance 0.98 Pain Relevance 0.11
AST caused overexpression of NAG-1, leading to PARP cleavage and apoptosis.
Gene_expression (cleavage) of PARP in cleavage associated with apoptosis
20) Confidence 0.22 Published 2009 Journal Int. J. Cancer Section Abstract Doc Link 19384947 Disease Relevance 0.41 Pain Relevance 0.15

General Comments

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