INT109920

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Context Info
Confidence 0.43
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.21
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PTK2B) protein complex assembly (PTK2B) response to stress (PTK2B)
cytoplasm (PTK2B) signal transducer activity (PTK2B) cytosol (PTK2B)
Anatomy Link Frequency
plasma 1
PTK2B (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 4 98.88 Very High Very High Very High
chemokine 104 88.96 High High
cINOD 1 86.96 High High
Central nervous system 4 23.68 Low Low
Inflammation 10 5.00 Very Low Very Low Very Low
antagonist 9 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
Opioid 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pituitary Cancer 2 98.48 Very High Very High Very High
Cancer 220 95.56 Very High Very High Very High
Apoptosis 111 93.04 High High
Death 8 89.32 High High
Reticuloendotheliosis 1 88.08 High High
INFLAMMATION 14 86.72 High High
Lung Cancer 6 79.48 Quite High
Carcinoma 96 77.80 Quite High
Sarcoma 2 68.36 Quite High
Skin Cancer 2 67.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, we used the Oncomine (http://www.oncomine.org/) data analysis tool to interrogate gene expression data reported by Asgharzadeh et al. (2006) for 19 genes that were upregulated by demethylation but did not show detectable CpG methylation (SNN, RASD1, ARPC4, PTK2B, TFAP4, ZFP36L2, ARHGDIA, suppressor of lin-12-like (SEL1L), LTBP3, smoothelin (SMTH), ST3 ?
Positive_regulation (upregulated) of PTK2B
1) Confidence 0.43 Published 2008 Journal Endocrine-Related Cancer Section Body Doc Link PMC2519165 Disease Relevance 0.27 Pain Relevance 0
Activation of extracellular signal-regulated protein kinase, endothelial nitric oxide synthase, and protein kinase B were assessed by Western blot analysis.
Positive_regulation (Activation) of protein kinase B
2) Confidence 0.32 Published 2009 Journal Anesthesiology Section Body Doc Link 19104173 Disease Relevance 0 Pain Relevance 0
These results suggest that activation of DEX-sensitive, CSA-resistant MEK/ERK and p38 pathways, and activation of NF-kappaB, PKC, and PTK are essential for IL-8 and MCP-1 expression by hRPE cells.
Positive_regulation (activation) of PTK associated with dexamethasone
3) Confidence 0.31 Published 2003 Journal Exp. Eye Res. Section Abstract Doc Link 12697421 Disease Relevance 0.09 Pain Relevance 0.35
Interestingly, ERK1/2 activation may involve either the classical Ras/Raf/MEK pathway or the activation of the cytosolic, Ca++-dependent tyrosine kinase Pyk2 [11].
Positive_regulation (activation) of Pyk2
4) Confidence 0.08 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 0.58 Pain Relevance 0.08
Active PI3K generates the phosphorylated lipid phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3), leading to the recruitment and activation of other kinases such as Akt (protein kinase B) to the plasma membrane.
Positive_regulation (activation) of protein kinase B in plasma
5) Confidence 0.07 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.27 Pain Relevance 0

General Comments

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