INT109921

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 5.07
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPK9) nucleoplasm (MAPK9) mitochondrion (MAPK9)
nucleus (MAPK9) transcription factor binding (MAPK9) response to stress (MAPK9)
Anatomy Link Frequency
monocytes 1
brain 1
MOLT-4 1
MAPK9 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 22 97.04 Very High Very High Very High
Enkephalin 13 96.80 Very High Very High Very High
Visceral pain 1 93.84 High High
long-term potentiation 1 87.24 High High
Hippocampus 1 86.32 High High
chemokine 11 82.20 Quite High
cINOD 1 59.76 Quite High
dexamethasone 4 57.84 Quite High
Dorsal horn 5 19.60 Low Low
Spinal cord 195 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 21 100.00 Very High Very High Very High
Apoptosis 59 99.48 Very High Very High Very High
Shock 7 99.00 Very High Very High Very High
INFLAMMATION 23 97.04 Very High Very High Very High
Cancer 25 94.20 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

1 93.84 High High
Colon Cancer 8 91.64 High High
Metastasis 3 87.28 High High
Retinal Diseases 1 79.12 Quite High
Myeloid Leukemia 25 76.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, it increased the phosphorylation level of c-Jun N-terminal kinase and induced apoptosis in MOLT-4 cells.
Phosphorylation (phosphorylation) of c-Jun N-terminal kinase in MOLT-4 associated with apoptosis
1) Confidence 0.67 Published 2009 Journal Cancer Sci. Section Abstract Doc Link 19141128 Disease Relevance 1.34 Pain Relevance 1.04
This decrease was maintained at 4 days post-transplant where hMNP-transplanted animals had 59.4% less phosphorylation of SAPK than controls (p<0.05).
Phosphorylation (phosphorylation) of SAPK
2) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912300 Disease Relevance 0.35 Pain Relevance 0.07
At 7 days post-transplant SAPK phosphorylation increased in hMNP-transplanted animals, however, no significant difference was observed between groups.
Phosphorylation (phosphorylation) of SAPK
3) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912300 Disease Relevance 0.47 Pain Relevance 0.10
hMNP transplantation altered intracellular signaling pathways (Fig. 5e,f). 1 day following transplantation, we observed an 86.3% decrease in phosphorylation of stress-associated protein kinase (SAPK) in hMNP-transplanted animals (p<0.001).
Phosphorylation (phosphorylation) of SAPK associated with stress
4) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912300 Disease Relevance 0.29 Pain Relevance 0.03
hMNP transplantation altered intracellular signaling pathways (Fig. 5e,f). 1 day following transplantation, we observed an 86.3% decrease in phosphorylation of stress-associated protein kinase (SAPK) in hMNP-transplanted animals (p<0.001).
Phosphorylation (phosphorylation) of stress-associated protein kinase associated with stress
5) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912300 Disease Relevance 0.29 Pain Relevance 0.03
Similarly, at 10 days post-transplant the two groups equilibrated and SAPK phosphorylation was not significantly different.
Phosphorylation (phosphorylation) of SAPK
6) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912300 Disease Relevance 0.59 Pain Relevance 0.12
Stimulation of hRPE cells by monocytes resulted in prominent increases in p38, ERK1/2 and JNK/SAPK phosphorolation, IkappaBalpha degradation, and NF-kappaB nuclear translocation.
Phosphorylation (phosphorolation) of SAPK in monocytes
7) Confidence 0.35 Published 2003 Journal Exp. Eye Res. Section Abstract Doc Link 12697421 Disease Relevance 0.14 Pain Relevance 0.24
In the present study we used immunoblotting techniques to examine the effects of acute and repeated restraint stress on the phosphorylation state of three MAPKs, the extracellular signal-regulated kinase Erk1/2, c-Jun-N-terminal kinase/stress-activated protein kinase (JNK/SAPK) and p38 MAPK, in different brain regions.
Spec (examine) Phosphorylation (phosphorylation) of SAPK in brain associated with stress
8) Confidence 0.35 Published 2003 Journal Brain Res. Section Abstract Doc Link 12850571 Disease Relevance 0.46 Pain Relevance 0.18
As expected, we observed that PEITC specifically inhibited the activating phosphorylation of SAPK induced by hyperosmotic shock using sorbitol (Figure 8, Panel A), consistent with the inhibition seen by in vitro kinase assay.
Phosphorylation (phosphorylation) of SAPK associated with shock
9) Confidence 0.13 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2071920 Disease Relevance 0.52 Pain Relevance 0
Finally, the proteosome inhibitor bortezomib or the MEK pathway inhibitor PD184352 when used in combination with SAHA also affects multiple signalling pathways, including induction of Jun Kinase (JNK) phosphorylation, inactivation of AKT and abrogation of NF-?
Phosphorylation (phosphorylation) of Jun Kinase
10) Confidence 0.06 Published 2010 Journal Invest New Drugs Section Body Doc Link PMC3003795 Disease Relevance 0.53 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox