INT109924

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Context Info
Confidence 0.73
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.07
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (EPHB2)
Anatomy Link Frequency
nucleus 2
monocytes 1
EPHB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 16 96.24 Very High Very High Very High
Osteoarthritis 63 92.76 High High
Inflammation 28 92.12 High High
bradykinin 12 91.00 High High
b2 receptor 3 89.16 High High
chemokine 7 84.48 Quite High
endometriosis 108 79.52 Quite High
cINOD 6 64.80 Quite High
Pain 3 63.92 Quite High
dexamethasone 4 62.88 Quite High
Disease Link Frequency Relevance Heat
Osteoarthritis 66 92.76 High High
INFLAMMATION 38 92.12 High High
Retinal Diseases 1 79.72 Quite High
Endometriosis 138 79.52 Quite High
Apoptosis 267 79.08 Quite High
Breast Cancer 1 75.84 Quite High
Malignant Neoplastic Disease 3 71.88 Quite High
Cancer 8 68.80 Quite High
Death 113 65.36 Quite High
Pressure And Volume Under Development 1 64.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stimulation of hRPE cells by monocytes resulted in prominent increases in p38, ERK1/2 and JNK/SAPK phosphorolation, IkappaBalpha degradation, and NF-kappaB nuclear translocation.
Localization (translocation) of ERK in monocytes
1) Confidence 0.73 Published 2003 Journal Exp. Eye Res. Section Abstract Doc Link 12697421 Disease Relevance 0.14 Pain Relevance 0.25
Intracellular effects of B2 stimulation were the following: (a) the increase of free intracellular Ca(2+) concentration by a mechanism dependent upon the phospholipase C (PLC) activity; (b) the cytosol-to-membrane translocation of conventional (PKC)-alpha and -beta isozymes, novel PKC-delta, -epsilon, and -eta isozymes; (c) the phosphorylation of the extracellular-regulated kinase 1 and 2 (ERK1/2); and (d) the stimulation of the expression of c-Fos protein.
Localization (translocation) of ERK
2) Confidence 0.73 Published 2004 Journal J. Cell. Physiol. Section Abstract Doc Link 15281091 Disease Relevance 0.40 Pain Relevance 0.50
The following primary antibodies were used: AXL (polyclonal, dilution 1:50, Santa Cruz Biotech., Santa Cruz, CA, USA), SHC1 (polyclonal, dilution 1:300, Santa Cruz Biotech.), phospho-Erk1/2 (monoclonal, dilution 1:50 Santa Cruz Biotech.), PI3KCA (polyclonal, dilution 1:50, Abgent, San Diego, CA, USA), phospho-Akt (Ser473) (clone 736E11, dilution 1:50, Cell Signaling Technology, Danvers, MA, USA), phospho-mTOR (Ser 2448) (clone 49F9, dilution 1:50, Cell Signaling Technology).
Localization (phospho) of Erk1
3) Confidence 0.73 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 0.34 Pain Relevance 0.10
B, while leptin-induced PGE2 production was reduced by inhibitors of JNK, p38, and Erk1/2 MAPkinases and transcription factor NF-?
Localization (/) of Erk1
4) Confidence 0.73 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.46 Pain Relevance 0.43
Ras-ERK1/2 activation leads to ERK1/2 translocation to the nucleus where they phosporylate Elk-1 and regulate the activity of transcription factors and co-activators, such as c-fos and CREB Binding Protein (CBP), involved in the control of gene expression.
Localization (translocation) of ERK1 in nucleus
5) Confidence 0.68 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.36 Pain Relevance 0
Ras-ERK1/2 activation leads to ERK1/2 translocation to the nucleus where they phosporylate Elk-1 and regulate the activity of transcription factors and co-activators, such as c-fos and CREB Binding Protein (CBP), involved in the control of gene expression.
Localization (translocation) of ERK in nucleus
6) Confidence 0.68 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.36 Pain Relevance 0

General Comments

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