INT109925

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Context Info
Confidence 0.65
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 16
Disease Relevance 12.46
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (RPE) cytosol (RPE) small molecule metabolic process (RPE)
carbohydrate metabolic process (RPE)
Anatomy Link Frequency
photoreceptors 4
eye 1
lung 1
RPE (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 4 98.06 Very High Very High Very High
cINOD 2 97.68 Very High Very High Very High
Inflammation 35 93.32 High High
chemokine 8 84.96 Quite High
anesthesia 4 66.36 Quite High
ischemia 1 59.28 Quite High
adenocard 18 56.00 Quite High
agonist 27 53.52 Quite High
potassium channel 14 50.60 Quite High
cva 8 49.60 Quite Low
Disease Link Frequency Relevance Heat
Choroideremia 498 100.00 Very High Very High Very High
Heart Rate Under Development 29 100.00 Very High Very High Very High
Congenital Anomalies 14 100.00 Very High Very High Very High
Age-related Macular Degeneration 457 99.84 Very High Very High Very High
Atelectasis 2 99.76 Very High Very High Very High
Disease 395 99.72 Very High Very High Very High
Stress 60 99.68 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 100 98.84 Very High Very High Very High
Retina Disease 110 98.44 Very High Very High Very High
Targeted Disruption 36 98.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, anti-inflammatory drugs dexamethasone (DEX) and cyclosporin A (CSA) both blocked activation of JNKS/SAPK and the cell-cell contact induced production of hRPE IL-8 and MCP-1, while activation of p38 and ERK was only inhibited by DEX, but not by CSA.
Gene_expression (production) of RPE associated with inflammation, cinod and dexamethasone
1) Confidence 0.65 Published 2003 Journal Exp. Eye Res. Section Abstract Doc Link 12697421 Disease Relevance 0.15 Pain Relevance 0.40
10, Dako), mouse anti-human CD42b:RPE-Cy5 and mouse anti-human CD38:RPE or mouse anti-human CD66:RPE.
Gene_expression (anti) of RPE
2) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.17 Pain Relevance 0.03
10, Dako), mouse anti-human CD42b:RPE-Cy5 and mouse anti-human CD38:RPE or mouse anti-human CD66:RPE.
Gene_expression (anti) of RPE
3) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.17 Pain Relevance 0.03
100, to detect the activated GPIIb/IIIa receptor, Becton Dickinson, San Jose, CA), mouse anti-human CD42b:RPE-Cy5 and mouse anti-human CD38:RPE (1?
Gene_expression (human) of RPE
4) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.16 Pain Relevance 0
This case demonstrates that delayed contralateral pulmonary edema with only radiographic evidence can emerge 4 days after resolution of RPE of a collapsed lung.
Gene_expression (resolution) of RPE in lung associated with atelectasis and heart rate under development
5) Confidence 0.59 Published 2009 Journal Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists Section Abstract Doc Link 19527970 Disease Relevance 1.67 Pain Relevance 0.11
Currently, it is accepted that when [K+]SRS is raised from 2mM to 5mM, RPE basal to apical 36Cl?
Gene_expression (raised) of RPE
6) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481396 Disease Relevance 0.09 Pain Relevance 0.03
Similarly, protocols for RPE production from ESCs are being refined, and functional studies on human ESC-derived RPE demonstrate their physiological viability [162].
Gene_expression (production) of RPE
7) Confidence 0.20 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962903 Disease Relevance 0.21 Pain Relevance 0
Derivation of iPSCs from patients with diseases causing outer retinal degeneration, alongside in vitro gene correction with a robust differentiation method for producing photoreceptor and RPE cells from these cells, could provide a source of autologous cells for transplantation.
Gene_expression (producing) of RPE in photoreceptor associated with disease and retina disease
8) Confidence 0.18 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962903 Disease Relevance 1.25 Pain Relevance 0.03
Geographic atrophy can develop following fading of drusen, in areas of RPE attenuation, following flattening of an RPE detachment, or after involution of choroidal neovascularization (CNV).
Gene_expression (detachment) of RPE associated with ocular toxicity (including many sub-types), age-related macular degeneration and geographic atrophy
9) Confidence 0.18 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2693968 Disease Relevance 2.36 Pain Relevance 0.03
Can we efficiently differentiate iPSCs to photoreceptors and RPE?
Gene_expression (differentiate) of RPE in photoreceptors
10) Confidence 0.15 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962903 Disease Relevance 0.35 Pain Relevance 0.03
A2E, which accumulates in the STGD eye, is also found in the RPE in AMD and perturbs efflux of cholesterol from RPE endosomes/lysosomes, causing cholesterol and cholesteryl ester deposit accumulation [61,126,127].
Gene_expression (found) of RPE in eye associated with age-related macular degeneration and disease
11) Confidence 0.15 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962903 Disease Relevance 1.09 Pain Relevance 0
Generation of photoreceptor and RPE cells from patient-specific iPSC lines overcomes the need for immunosuppression and will likely reduce the risk of rejection of grafted tissue within the neurally depleted region.
Gene_expression (Generation) of RPE in photoreceptor
12) Confidence 0.14 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962903 Disease Relevance 0.92 Pain Relevance 0
A knock-in mouse carrying a Ser156Cys mutation in the orthologous murine TIMP3 gene shows clinical features of human SFD, including abnormalities and elevated TIMP3 in Bruch's membrane and RPE [68,81], providing an experimental system in which to investigate SFD pathophysiology.
Gene_expression (features) of RPE associated with targeted disruption and congenital anomalies
13) Confidence 0.07 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962903 Disease Relevance 0.99 Pain Relevance 0
Rab27 is also present at high levels in the RPE and choriocapillaris and its under-prenylation could contribute to the degenerative process.
Gene_expression (levels) of RPE
14) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.84 Pain Relevance 0
Rab27 is also present at high levels in the RPE and choriocapillaris and its under-prenylation could contribute to the degenerative process.
Gene_expression (present) of RPE
15) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.84 Pain Relevance 0
The RPE and photoreceptors in a chronic disorder such as CHM are probably constantly subjected to the stress caused by the lysosomal dysfunction and accumulate sub-toxic changes with age, which lead to the development of disease.
Gene_expression (subjected) of RPE in photoreceptors associated with stress, choroideremia and disease
16) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 1.06 Pain Relevance 0

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