INT109926

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.87
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPK8) nucleoplasm (MAPK8) mitochondrion (MAPK8)
nucleus (MAPK8) response to stress (MAPK8) cytoplasm (MAPK8)
Anatomy Link Frequency
monocytes 4
nucleus 2
MAPK8 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 13 97.86 Very High Very High Very High
Inflammatory mediators 2 89.68 High High
Inflammatory response 8 87.12 High High
cINOD 3 64.80 Quite High
dexamethasone 11 62.88 Quite High
cytokine 31 62.72 Quite High
Inflammation 54 50.00 Quite Low
rheumatoid arthritis 2 9.20 Low Low
Arthritis 10 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 4 99.98 Very High Very High Very High
Retinal Diseases 2 92.64 High High
Osteoarthritis 4 90.04 High High
INFLAMMATION 71 89.28 High High
Adhesions 12 61.44 Quite High
Aging 23 50.00 Quite Low
Osteoporosis 43 42.44 Quite Low
Arthritis 11 18.12 Low Low
Disease 23 14.00 Low Low
Rheumatoid Arthritis 2 9.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stimulation of hRPE cells by monocytes resulted in prominent increases in p38, ERK1/2 and JNK/SAPK phosphorolation, IkappaBalpha degradation, and NF-kappaB nuclear translocation.
Positive_regulation (increases) of Localization (translocation) of JNK in monocytes
1) Confidence 0.49 Published 2003 Journal Exp. Eye Res. Section Abstract Doc Link 12697421 Disease Relevance 0.14 Pain Relevance 0.25
This study investigates chemokine secretion induced by co-culture of hRPE cells and monocytes and illustrates the roles of p38 kinase, ERK, JNK/SAPK and NF-kappaB-inducing kinase signaling pathways for hRPE IL-8 and MCP-1 secretion induced in hRPE by co-culture with monocytes.
Positive_regulation (induced) of Localization (secretion) of JNK in monocytes associated with chemokine
2) Confidence 0.49 Published 2003 Journal Exp. Eye Res. Section Abstract Doc Link 12697421 Disease Relevance 0.09 Pain Relevance 0.12
Indeed, our recent studies have shown that activation of the p38, ERK, and JNK MAP kinases is required for the chondrogenic induction and maintenance of TGF-?
Positive_regulation (activation) of Localization (kinases) of JNK
3) Confidence 0.14 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154434 Disease Relevance 0.23 Pain Relevance 0
It has been demonstrated that during reperfusion, oxidative stress leads to activation and translocation of JNK to the nucleus, where phosphorylation of transcription factors, such as c-Jun occurs.


Positive_regulation (leads) of Localization (translocation) of JNK in nucleus associated with stress
4) Confidence 0.04 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.40 Pain Relevance 0.15

General Comments

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