INT109927

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Context Info
Confidence 0.32
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.24
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPK9) nucleoplasm (MAPK9) mitochondrion (MAPK9)
nucleus (MAPK9) transcription factor binding (MAPK9) response to stress (MAPK9)
Anatomy Link Frequency
monocytes 2
MAPK9 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 10 97.78 Very High Very High Very High
cINOD 2 64.80 Quite High
dexamethasone 8 62.88 Quite High
Disease Link Frequency Relevance Heat
Retinal Diseases 2 92.48 High High
INFLAMMATION 2 64.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study investigates chemokine secretion induced by co-culture of hRPE cells and monocytes and illustrates the roles of p38 kinase, ERK, JNK/SAPK and NF-kappaB-inducing kinase signaling pathways for hRPE IL-8 and MCP-1 secretion induced in hRPE by co-culture with monocytes.
Localization (secretion) of SAPK in monocytes associated with chemokine
1) Confidence 0.32 Published 2003 Journal Exp. Eye Res. Section Abstract Doc Link 12697421 Disease Relevance 0.09 Pain Relevance 0.12
Stimulation of hRPE cells by monocytes resulted in prominent increases in p38, ERK1/2 and JNK/SAPK phosphorolation, IkappaBalpha degradation, and NF-kappaB nuclear translocation.
Localization (translocation) of SAPK in monocytes
2) Confidence 0.32 Published 2003 Journal Exp. Eye Res. Section Abstract Doc Link 12697421 Disease Relevance 0.14 Pain Relevance 0.25

General Comments

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