INT109929

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Context Info
Confidence 0.81
First Reported 2003
Last Reported 2011
Negated 1
Speculated 4
Reported most in Abstract
Documents 102
Total Number 112
Disease Relevance 39.98
Pain Relevance 16.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPK8) nucleoplasm (MAPK8) mitochondrion (MAPK8)
nucleus (MAPK8) response to stress (MAPK8) cytoplasm (MAPK8)
Anatomy Link Frequency
Caco-2 3
chondrocytes 2
brain 2
colon 1
epithelial cells 1
MAPK8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 921 100.00 Very High Very High Very High
Osteoarthritis 739 100.00 Very High Very High Very High
Morphine 10 99.52 Very High Very High Very High
dexamethasone 126 99.44 Very High Very High Very High
Nicotine 673 99.38 Very High Very High Very High
Paracetamol 10 99.34 Very High Very High Very High
qutenza 26 99.12 Very High Very High Very High
Rheumatism 2 99.12 Very High Very High Very High
cINOD 62 98.98 Very High Very High Very High
cytokine 362 98.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1060 100.00 Very High Very High Very High
Osteoarthritis 749 100.00 Very High Very High Very High
Stress 356 100.00 Very High Very High Very High
Diabetes Mellitus 10 99.74 Very High Very High Very High
Apoptosis 742 99.54 Very High Very High Very High
Obesity 25 99.46 Very High Very High Very High
Breast Cancer 208 99.12 Very High Very High Very High
Rheumatic Diseases 18 99.12 Very High Very High Very High
Colon Cancer 37 98.96 Very High Very High Very High
Arthritis 59 98.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ROS in turn exerted feedback regulation on JNK activation, as shown by the observations that cyclosporin A and the antioxidant N-acetylcysteine significantly inhibited the phosphorylation of JNK induced by morphine.
Phosphorylation (phosphorylation) of JNK associated with morphine
1) Confidence 0.81 Published 2009 Journal FEBS J. Section Abstract Doc Link 19292871 Disease Relevance 0.38 Pain Relevance 0.69
Stimulation of hRPE cells by monocytes resulted in prominent increases in p38, ERK1/2 and JNK/SAPK phosphorolation, IkappaBalpha degradation, and NF-kappaB nuclear translocation.
Phosphorylation (phosphorolation) of JNK in monocytes
2) Confidence 0.79 Published 2003 Journal Exp. Eye Res. Section Abstract Doc Link 12697421 Disease Relevance 0.14 Pain Relevance 0.24
In the present study we used immunoblotting techniques to examine the effects of acute and repeated restraint stress on the phosphorylation state of three MAPKs, the extracellular signal-regulated kinase Erk1/2, c-Jun-N-terminal kinase/stress-activated protein kinase (JNK/SAPK) and p38 MAPK, in different brain regions.
Spec (examine) Phosphorylation (phosphorylation) of JNK in brain associated with stress
3) Confidence 0.79 Published 2003 Journal Brain Res. Section Abstract Doc Link 12850571 Disease Relevance 0.46 Pain Relevance 0.18
Immunofluorescence staining and Western blot using anti-phospho-JNK antibody showed that JNK was phosphorylated at Thr183 and Tyr185 in the activation T-loop in cells treated with H2O2 when compared with that in control cells (Fig. 5, A and B, lane 2), as well as in HEK293T cells (data not shown).
Phosphorylation (phosphorylated) of JNK
4) Confidence 0.75 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.23 Pain Relevance 0
The level of phosphorylated JNK was evidently increased in the brains of AD patients when compared with control brains, whereas there was no significant difference in JNK expression level (Fig. 7A), consistent with previous reports (36, 37).


Phosphorylation (phosphorylated) of JNK in brains associated with alzheimer's dementia
5) Confidence 0.75 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.74 Pain Relevance 0.05
It has been reported that JNK can phosphorylate the ?
Phosphorylation (phosphorylate) of JNK
6) Confidence 0.75 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.08 Pain Relevance 0
It is possible that JNK phosphorylates APP and thereby makes it a better substrate for ?
Phosphorylation (phosphorylates) of JNK
7) Confidence 0.75 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.18 Pain Relevance 0.04
AEA triggered phosphorylation of c-Jun NH(2)-terminal kinase (JNK) and p38 mitogen activated protein kinase.
Phosphorylation (phosphorylation) of JNK
8) Confidence 0.66 Published 2003 Journal Thromb. Haemost. Section Abstract Doc Link 12719786 Disease Relevance 0.82 Pain Relevance 0.20
The phosphorylation of p38 MAPK and c-Jun NH2-terminal kinase (JNK) were detected after capsaicin stimulation. p38 MAPK is involved in capsaicin-induced IL-6 production, as shown by the use of specific inhibitors of this kinase.
Phosphorylation (phosphorylation) of JNK associated with qutenza
9) Confidence 0.63 Published 2005 Journal J Endod Section Abstract Doc Link 16123700 Disease Relevance 0.17 Pain Relevance 0.88
The phosphorylation of p38 MAPK and c-Jun NH2-terminal kinase (JNK) were detected after capsaicin stimulation. p38 MAPK is involved in capsaicin-induced IL-6 production, as shown by the use of specific inhibitors of this kinase.
Phosphorylation (phosphorylation) of c-Jun NH2-terminal kinase associated with qutenza
10) Confidence 0.63 Published 2005 Journal J Endod Section Abstract Doc Link 16123700 Disease Relevance 0.16 Pain Relevance 0.88
Furthermore, Trolox attenuated indomethacin-induced increased phosphorylation in ERK, p38 MAPK, JNK, and AKT.
Phosphorylation (phosphorylation) of JNK
11) Confidence 0.63 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17341418 Disease Relevance 0.55 Pain Relevance 0
Pharmacologic activation of PKG with YC-1 increases JNK phosphorylation and induces apoptosis in colon cancer cells without modulating ERK1/2 phosphorylation or beta-catenin protein expression.
Phosphorylation (phosphorylation) of JNK in colon associated with colon cancer and apoptosis
12) Confidence 0.61 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16546990 Disease Relevance 1.11 Pain Relevance 0.14
Inhibition of ERK1/2 with U0126 induces apoptosis but fails to activate JNK phosphorylation or down-regulate beta-catenin protein expression.
Phosphorylation (phosphorylation) of JNK associated with apoptosis
13) Confidence 0.61 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16546990 Disease Relevance 1.12 Pain Relevance 0.12
In this study, we have demonstrated the kinetics of phosphorylation and nuclear
               accumulation of JNK1, WOX1 and transcription factors during the acute and chronic
               phases of sciatic nerve transection in rats and in p53 knockout mice. 
Phosphorylation (phosphorylation) of JNK1 in sciatic nerve associated with targeted disruption and sciatic nerve
14) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771921 Disease Relevance 0.87 Pain Relevance 0.05
Moreover, IL-6 also induced phosphorylation of JNK1/2, p38MAPK, and ERK1/2 for 24 h and activated the degradation of I?
Phosphorylation (phosphorylation) of JNK1
15) Confidence 0.61 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0 Pain Relevance 0.10
By transfection of TAK1 siRNA, TNFalpha-induced phosphorylation of IkappaBalpha, JNK1/2, and p38MAPK, as well as IL-6 or IL-8 expression, were repressed.
Phosphorylation (phosphorylation) of JNK1
16) Confidence 0.61 Published 2009 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 19410630 Disease Relevance 0.39 Pain Relevance 0.19
Instead, we demonstrate that leflunomide (20 microM) inhibited the APAP-induced early (3 h) activation (phosphorylation) of JNK1/2, thus inhibiting phosphorylation of the anti-apoptotic protein Bcl-2 and preventing P-Bcl-2-mediated induction of the mPT.
Phosphorylation (phosphorylation) of JNK associated with paracetamol, leflunomide and apoptosis
17) Confidence 0.61 Published 2006 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 16979204 Disease Relevance 0.73 Pain Relevance 0.96
Both CAP and WIN induced transient increases in Erk1/2, p38, JNK1/2 MAPK and Akt/PI-3K phosphorylation status resulting in cell proliferation and migration increases which mirrored those elicited by EGF.
Phosphorylation (phosphorylation) of JNK1
18) Confidence 0.61 Published 2010 Journal Exp. Eye Res. Section Abstract Doc Link 20619260 Disease Relevance 0.14 Pain Relevance 0.63
Western blot analysis revealed that EBC1-Ps had higher JNK phosphorylation levels than EBC1-Vs, and sp600125-treated EBC1-Ps showed similar levels of phosphorylated JNK as in EBC1-Vs (Figure 6B).
Phosphorylation (phosphorylated) of JNK
19) Confidence 0.59 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0 Pain Relevance 0
As a result, significant upregulation of VEGF-C mRNA (Figure 6C) and a decreased level of phosphorylated JNK (Figure 6D) were induced in EBC1-P4 cells treated with siRNA-podoplanin.
Phosphorylation (phosphorylated) of JNK
20) Confidence 0.59 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.07 Pain Relevance 0

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