INT10993

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Context Info
Confidence 0.26
First Reported 1992
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 2.04
Pain Relevance 1.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PARP1) nuclear envelope (PARP1) transferase activity, transferring glycosyl groups (PARP1)
intracellular (PARP1) DNA binding (PARP1) nucleolus (PARP1)
Anatomy Link Frequency
spinal 2
poly 1
NG108-15 1
PARP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 5 98.68 Very High Very High Very High
long-term potentiation 24 98.44 Very High Very High Very High
agonist 4 97.24 Very High Very High Very High
c fibre 6 93.72 High High
Lasting pain 2 93.04 High High
central sensitization 2 91.64 High High
allodynia 1 76.40 Quite High
opiate 2 75.00 Quite High
Neuropathic pain 1 75.00 Quite High
Dorsal horn 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Injury 11 98.44 Very High Very High Very High
Bordatella Infection 2 98.38 Very High Very High Very High
Nociception 2 97.60 Very High Very High Very High
Apoptosis 55 97.44 Very High Very High Very High
Pain 2 93.04 High High
Hepatotoxicity 14 90.00 High High
Neuropathic Pain 2 76.40 Quite High
Body Weight 28 70.76 Quite High
Toxicity 5 67.28 Quite High
Stress 18 27.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blot analysis showed no change either on poly-ADP ribose polymerase (PARP) or p53 transcription factor in CCI and sham rats.
Neg (no) Regulation (change) of poly-ADP ribose polymerase in poly associated with injury
1) Confidence 0.26 Published 2002 Journal Neuroreport Section Abstract Doc Link 11924868 Disease Relevance 1.09 Pain Relevance 0.43
The present study examined the roles of soluble guanylate cyclase (sGC) or ADP-ribosyltransferase (ADPRT), two potential NO targets, in spinal LTP.
Spec (examined) Regulation (roles) of ADPRT in spinal associated with long-term potentiation
2) Confidence 0.11 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16427664 Disease Relevance 0.10 Pain Relevance 0.54
The present study examined the roles of soluble guanylate cyclase (sGC) or ADP-ribosyltransferase (ADPRT), two potential NO targets, in spinal LTP.
Spec (examined) Regulation (roles) of ADP-ribosyltransferase in spinal associated with long-term potentiation
3) Confidence 0.11 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16427664 Disease Relevance 0.10 Pain Relevance 0.54
In addition, anti-apoptotic action of taurine was evaluated by measuring the mitochondrial membrane potential, intracellular ATP level, DNA fragmentation, alterations of the Bcl-2 family proteins, Bim, cytosolic cytochrome C, activities of Apaf-1, caspase 9, caspase 3, and PARP.
Regulation (alterations) of PARP associated with apoptosis
4) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.58 Pain Relevance 0
Exposure of NG108-15 cells to DADLE alone or DADLE plus carbachol had no effect on the capacity of pertussis toxin to ADP-ribosylate membrane proteins in these cells; neither was there any change in the activity of eukaryotic ADP-ribosyltransferase expressed in these cells.
Regulation (change) of eukaryotic ADP-ribosyltransferase in NG108-15 associated with bordatella infection
5) Confidence 0.01 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1530867 Disease Relevance 0.10 Pain Relevance 0.19
The underlying mechanism for the changes in agonist-dependent stimulatory responses or Gpp(NH)p-dependent inhibition of adenylate cyclase remains obscure, but appears not to be mediated by eukaryotic ADP-ribosyltransferase activity or a change in the abundance of G proteins known to regulate adenylate cyclase.
Regulation (change) of eukaryotic ADP-ribosyltransferase associated with agonist
6) Confidence 0.01 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1530867 Disease Relevance 0.08 Pain Relevance 0.19

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