INT109932

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Context Info
Confidence 0.86
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.14
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (EPHB2)
Anatomy Link Frequency
monocytes 1
L929 1
EPHB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 5 82.80 Quite High
cINOD 1 61.84 Quite High
dexamethasone 4 59.92 Quite High
Glutamate 3 30.56 Quite Low
tetrodotoxin 11 5.00 Very Low Very Low Very Low
Kinase C 6 5.00 Very Low Very Low Very Low
depression 5 5.00 Very Low Very Low Very Low
Glutamate receptor 4 5.00 Very Low Very Low Very Low
nMDA receptor 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retinal Diseases 1 79.72 Quite High
INFLAMMATION 1 61.44 Quite High
Cancer 12 50.00 Quite Low
Glioma 6 5.00 Very Low Very Low Very Low
Depression 5 5.00 Very Low Very Low Very Low
Adhesions 3 5.00 Very Low Very Low Very Low
Adenocarcinoma 2 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 2 5.00 Very Low Very Low Very Low
Epilepsy 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stimulation of hRPE cells by monocytes resulted in prominent increases in p38, ERK1/2 and JNK/SAPK phosphorolation, IkappaBalpha degradation, and NF-kappaB nuclear translocation.
Protein_catabolism (degradation) of ERK in monocytes
1) Confidence 0.86 Published 2003 Journal Exp. Eye Res. Section Abstract Doc Link 12697421 Disease Relevance 0.14 Pain Relevance 0.24
Blocking the ERK1/2 pathway with MEK1 inhibitor PD98059 (25 ?
Protein_catabolism (pathway) of ERK1
2) Confidence 0.86 Published 2009 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2667352 Disease Relevance 0 Pain Relevance 0
Effects of VPA on individual cell motility and the degree of Erk1/2 phosphorylation in L929 cells
Protein_catabolism (degree) of Erk1 in L929
3) Confidence 0.86 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0 Pain Relevance 0

General Comments

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