INT109933

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Context Info
Confidence 0.41
First Reported 2003
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.68
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPK9) nucleoplasm (MAPK9) mitochondrion (MAPK9)
nucleus (MAPK9) transcription factor binding (MAPK9) response to stress (MAPK9)
MAPK9 (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 4 99.38 Very High Very High Very High
cINOD 1 99.00 Very High Very High Very High
chemokine 5 87.60 High High
cytokine 2 5.00 Very Low Very Low Very Low
Immobilon 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 12 99.32 Very High Very High Very High
INFLAMMATION 3 98.88 Very High Very High Very High
Stress 20 55.32 Quite High
Retinal Diseases 1 55.28 Quite High
Apoptosis 32 25.00 Low Low
Cancer 14 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Pox Virus Infection 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, anti-inflammatory drugs dexamethasone (DEX) and cyclosporin A (CSA) both blocked activation of JNKS/SAPK and the cell-cell contact induced production of hRPE IL-8 and MCP-1, while activation of p38 and ERK was only inhibited by DEX, but not by CSA.
Negative_regulation (blocked) of Positive_regulation (activation) of SAPK associated with inflammation, cinod and dexamethasone
1) Confidence 0.41 Published 2003 Journal Exp. Eye Res. Section Abstract Doc Link 12697421 Disease Relevance 0.15 Pain Relevance 0.40
As expected, we observed that PEITC specifically inhibited the activating phosphorylation of SAPK induced by hyperosmotic shock using sorbitol (Figure 8, Panel A), consistent with the inhibition seen by in vitro kinase assay.
Negative_regulation (inhibited) of Positive_regulation (induced) of SAPK associated with shock
2) Confidence 0.09 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2071920 Disease Relevance 0.52 Pain Relevance 0
These results demonstrate that MEKK1 is directly modified and inhibited by ITCs, and that this correlates with inhibition of downstream activation of SAPK.
Negative_regulation (inhibition) of Positive_regulation (activation) of SAPK
3) Confidence 0.09 Published 2007 Journal BMC Cancer Section Abstract Doc Link PMC2071920 Disease Relevance 0 Pain Relevance 0

General Comments

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