INT109935

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Context Info
Confidence 0.68
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 35
Total Number 38
Disease Relevance 13.13
Pain Relevance 4.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPK8) nucleoplasm (MAPK8) mitochondrion (MAPK8)
nucleus (MAPK8) response to stress (MAPK8) cytoplasm (MAPK8)
Anatomy Link Frequency
Caco-2 4
chondrocytes 2
monocytes 2
colon 2
brains 2
MAPK8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 10 99.84 Very High Very High Very High
Nicotine 192 99.78 Very High Very High Very High
Inflammation 187 96.12 Very High Very High Very High
cytokine 58 94.56 High High
Inflammatory response 21 93.80 High High
Hippocampus 1 93.80 High High
Osteoarthritis 106 92.52 High High
Kinase C 10 89.04 High High
antagonist 41 86.88 High High
chemokine 38 83.52 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 203 99.72 Very High Very High Very High
Alzheimer's Dementia 36 99.28 Very High Very High Very High
Breast Cancer 104 99.12 Very High Very High Very High
Colon Cancer 26 98.96 Very High Very High Very High
Stress 105 96.80 Very High Very High Very High
INFLAMMATION 225 96.12 Very High Very High Very High
Osteoarthritis 107 92.52 High High
Cancer 800 90.72 High High
Skin Cancer 141 89.36 High High
Amyloid Plaque 35 87.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ROS in turn exerted feedback regulation on JNK activation, as shown by the observations that cyclosporin A and the antioxidant N-acetylcysteine significantly inhibited the phosphorylation of JNK induced by morphine.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of JNK associated with morphine
1) Confidence 0.68 Published 2009 Journal FEBS J. Section Abstract Doc Link 19292871 Disease Relevance 0.38 Pain Relevance 0.75
In addition, significant upregulation of VEGF-C mRNA (Figure 7B) and a decreased level of phosphorylated JNK (Figure 7C) were also induced in H157 cells treated with siRNA-podoplanin.
Positive_regulation (induced) of Phosphorylation (phosphorylated) of JNK
2) Confidence 0.50 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.17 Pain Relevance 0
As a result, significant upregulation of VEGF-C mRNA (Figure 6C) and a decreased level of phosphorylated JNK (Figure 6D) were induced in EBC1-P4 cells treated with siRNA-podoplanin.
Positive_regulation (induced) of Phosphorylation (phosphorylated) of JNK
3) Confidence 0.50 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.07 Pain Relevance 0
A decreased level of phosphorylated JNK but not of total JNK was induced by siRNA-mediated podoplanin knockdown (Figures 6D and 7C), suggesting that podoplanin could induce JNK phosphorylation.
Positive_regulation (induced) of Phosphorylation (phosphorylated) of JNK
4) Confidence 0.50 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.26 Pain Relevance 0.04
Stimulation of hRPE cells by monocytes resulted in prominent increases in p38, ERK1/2 and JNK/SAPK phosphorolation, IkappaBalpha degradation, and NF-kappaB nuclear translocation.
Positive_regulation (increases) of Phosphorylation (phosphorolation) of JNK in monocytes
5) Confidence 0.49 Published 2003 Journal Exp. Eye Res. Section Abstract Doc Link 12697421 Disease Relevance 0.14 Pain Relevance 0.24
The level of phosphorylated JNK was evidently increased in the brains of AD patients when compared with control brains, whereas there was no significant difference in JNK expression level (Fig. 7A), consistent with previous reports (36, 37).


Positive_regulation (increased) of Phosphorylation (phosphorylated) of JNK in brains associated with alzheimer's dementia
6) Confidence 0.46 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.74 Pain Relevance 0.05
Furthermore, Trolox attenuated indomethacin-induced increased phosphorylation in ERK, p38 MAPK, JNK, and AKT.
Positive_regulation (indomethacin-induced) of Phosphorylation (phosphorylation) of JNK
7) Confidence 0.38 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17341418 Disease Relevance 0.61 Pain Relevance 0.05
Furthermore, Trolox attenuated indomethacin-induced increased phosphorylation in ERK, p38 MAPK, JNK, and AKT.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of JNK
8) Confidence 0.38 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17341418 Disease Relevance 0.60 Pain Relevance 0
Inhibition of ERK1/2 with U0126 induces apoptosis but fails to activate JNK phosphorylation or down-regulate beta-catenin protein expression.
Neg (fails) Positive_regulation (activate) of Phosphorylation (phosphorylation) of JNK associated with apoptosis
9) Confidence 0.37 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16546990 Disease Relevance 1.12 Pain Relevance 0.12
Pharmacologic activation of PKG with YC-1 increases JNK phosphorylation and induces apoptosis in colon cancer cells without modulating ERK1/2 phosphorylation or beta-catenin protein expression.
Positive_regulation (increases) of Phosphorylation (phosphorylation) of JNK in colon associated with colon cancer and apoptosis
10) Confidence 0.37 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16546990 Disease Relevance 1.12 Pain Relevance 0.14
A decreased level of phosphorylated JNK but not of total JNK was induced by siRNA-mediated podoplanin knockdown (Figures 6D and 7C), suggesting that podoplanin could induce JNK phosphorylation.
Positive_regulation (mediated) of Phosphorylation (phosphorylated) of JNK
11) Confidence 0.36 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.26 Pain Relevance 0.04
By contrast, as shown in Figure 6B, not only the phosphorylated JNK but also the total JNK levels were apparently increased in stable transformants exogenously expressing podoplanin.
Positive_regulation (increased) of Phosphorylation (phosphorylated) of JNK
12) Confidence 0.36 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.20 Pain Relevance 0.04
Western blot analysis revealed that EBC1-Ps had higher JNK phosphorylation levels than EBC1-Vs, and sp600125-treated EBC1-Ps showed similar levels of phosphorylated JNK as in EBC1-Vs (Figure 6B).
Positive_regulation (levels) of Phosphorylation (phosphorylation) of JNK
13) Confidence 0.36 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.05 Pain Relevance 0
In addition, significant upregulation of VEGF-C mRNA (Figure 7B) and a decreased level of phosphorylated JNK (Figure 7C) were also induced in H157 cells treated with siRNA-podoplanin.
Positive_regulation (upregulation) of Phosphorylation (phosphorylated) of JNK
14) Confidence 0.36 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.17 Pain Relevance 0
We found increased phosphorylation of JNK and p38 in samples stimulated with IL-1?
Positive_regulation (increased) of Phosphorylation (phosphorylation) of JNK
15) Confidence 0.34 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212570 Disease Relevance 0.38 Pain Relevance 0.19
By contrast, as shown in Figure 6B, not only the phosphorylated JNK but also the total JNK levels were apparently increased in stable transformants exogenously expressing podoplanin.
Positive_regulation (increased) of Phosphorylation (phosphorylated) of JNK
16) Confidence 0.34 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.20 Pain Relevance 0.04
Interestingly, we revealed that the expression of P-glycoprotein was down regulated dose-dependently in R-HepG2 cells at 2 h after Pa-PDT treatment (Figure 4A), with induction of phosphorylated JNK and down-regulation of a PDT-resistant protein p-Erk when compared to the control that was treated with 0.4 ?
Positive_regulation (induction) of Phosphorylation (phosphorylated) of JNK
17) Confidence 0.31 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2731730 Disease Relevance 0.13 Pain Relevance 0
stimulated JNK phosphorylation (Panel A) and activity (Panels B and C).
Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of JNK
18) Confidence 0.25 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0 Pain Relevance 0
stimulated JNK phosphorylation and activity as expected, and this was inhibited by the pre-treatment with SLIGKV-OH.
Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of JNK
19) Confidence 0.25 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0 Pain Relevance 0
We found increased phosphorylation of JNK and p38 in samples stimulated with IL-1?
Positive_regulation (samples) of Phosphorylation (phosphorylation) of JNK
20) Confidence 0.25 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212570 Disease Relevance 0.38 Pain Relevance 0.19

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