INT109950

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.37
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 4.06
Pain Relevance 1.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Pitpnm1) lipid particle (Pitpnm1) Golgi apparatus (Pitpnm1)
endoplasmic reticulum (Pitpnm1) intracellular (Pitpnm1) cytoplasm (Pitpnm1)
Anatomy Link Frequency
hepatocytes 2
Pitpnm1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 33 98.16 Very High Very High Very High
adenocard 1 87.64 High High
Quantitative sensory testing 32 82.52 Quite High
Inflammation 1 75.00 Quite High
cINOD 2 50.84 Quite High
fifth nerve 3 50.00 Quite Low
aspirin 1 45.36 Quite Low
Pain 15 5.00 Very Low Very Low Very Low
Pain threshold 4 5.00 Very Low Very Low Very Low
Paresthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 6 99.96 Very High Very High Very High
Toxicity 8 99.76 Very High Very High Very High
Apoptosis 21 99.50 Very High Very High Very High
Death 7 98.48 Very High Very High Very High
Necrosis 8 97.12 Very High Very High Very High
Cancer 2 97.04 Very High Very High Very High
Injury 9 93.96 High High
Parkinson's Disease 2 83.96 Quite High
Overdose 2 79.40 Quite High
Hepatocellular Cancer 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
METHODS: Male CD-1 mice were given intraperitoneally acetaminophen (350 mg/kg) without or with cyclosporin A (50 mg/kg), a specific inhibitor of MPT.
Negative_regulation (inhibitor) of MPT
1) Confidence 0.37 Published 2005 Journal J. Hepatol. Section Body Doc Link 15629515 Disease Relevance 0.09 Pain Relevance 0
In the presence of fructose plus glycine, CsA decreased apoptosis and delayed but did not prevent the MPT.
Negative_regulation (prevent) of MPT associated with apoptosis
2) Confidence 0.36 Published 2004 Journal Hepatology Section Abstract Doc Link 15486922 Disease Relevance 0.48 Pain Relevance 0.66
The oxidative phase occurs with increased oxidative stress, loss of mitochondrial membrane potential, MPT, and toxicity.
Negative_regulation (loss) of MPT associated with stress and toxicity
3) Confidence 0.35 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15466245 Disease Relevance 0.78 Pain Relevance 0.44
Acetaminophen (10 micromol/L) induced necrotic killing in approximately 50% of hepatocytes after 6 h and cyclosporin A (CsA), MPT inhibitor, temporarily decreased necrotic killing after 6 h, but cytoprotection was lost after 16 h.
Negative_regulation (inhibitor) of MPT in hepatocytes associated with paracetamol
4) Confidence 0.34 Published 2007 Journal J. Gastroenterol. Hepatol. Section Abstract Doc Link 17567465 Disease Relevance 0.71 Pain Relevance 0.71
In necrotic killing models to rat hepatocytes, salicylate (1 mM) enhanced calcium ionophore (Br-A23187)- and tert-butylhydroperoxide (t-BuOOH)-induced cell death, which was blocked or delayed by cyclosporin A (CsA, 2 microM), a specific inhibitor of the MPT.
Negative_regulation (inhibitor) of MPT in hepatocytes associated with death
5) Confidence 0.05 Published 2003 Journal Toxicol. Sci. Section Abstract Doc Link 12700412 Disease Relevance 1.27 Pain Relevance 0
MPT decreased only within the first 4 weeks.
Negative_regulation (decreased) of MPT
6) Confidence 0.02 Published 2010 Journal Head Face Med Section Body Doc Link PMC2984556 Disease Relevance 0 Pain Relevance 0.08
Coincubation with either cyclosporin A (an MPT inhibitor) or the combination of fructose-1,6-diphosphate (a glycolysis substrate) and oligomycin (an ATPase inhibitor) prevented the decrease in DeltaPsim, ATP depletion, and cell death.
Negative_regulation (inhibitor) of MPT associated with death
7) Confidence 0.00 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16617166 Disease Relevance 0.73 Pain Relevance 0.09

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox