INT109960

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.74
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (ABCC8) ATPase activity (ABCC8) plasma membrane (ABCC8)
carbohydrate metabolic process (ABCC8) transmembrane transport (ABCC8)
Anatomy Link Frequency
forearm 1
T cells 1
ABCC8 (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 5 98.36 Very High Very High Very High
rheumatoid arthritis 19 87.24 High High
cytokine 12 82.28 Quite High
anesthesia 1 80.80 Quite High
Inflammation 11 69.88 Quite High
Infliximab 9 50.00 Quite Low
member 8 1 27.12 Quite Low
cINOD 8 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
methotrexate 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperinsulinism 3 100.00 Very High Very High Very High
Diabetes Mellitus 32 93.40 High High
Rheumatoid Arthritis 19 87.24 High High
INFLAMMATION 11 69.88 Quite High
Crystal Associated Disease 97 68.48 Quite High
Adhesions 12 62.08 Quite High
Ocular Toxicity (including Many Sub-types) 1 61.76 Quite High
Diabetic Nephropathy 4 53.28 Quite High
Hyperuricemia 14 53.12 Quite High
Disease 14 52.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On activating KCNJ11 or ABCC8 mutations, the response of the channel to ATP reduces, thereby preventing channel closure and consequent insulin secretion.
Positive_regulation (activating) of ABCC8
1) Confidence 0.49 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2571058 Disease Relevance 0.81 Pain Relevance 0
In line with these findings, there was increased infiltration by macrophages, including CD163+ resident tissue macrophages and MRP8+ and MRP14+ infiltrating macrophages, as well as T cells in responders vs non-responders.
Positive_regulation (increased) of MRP8 in T cells
2) Confidence 0.21 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564801 Disease Relevance 0.48 Pain Relevance 0.23
Excessive consumption of alcohol (particularly beer), sweetened soft drinks, fructose, meat, and seafood can also increase levels of serum urate (sUr).12
Positive_regulation (increase) of sUr associated with alcohol
3) Confidence 0.20 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2817937 Disease Relevance 0.29 Pain Relevance 0.05
This study was undertaken to investigate if a nonpharmacologic increase in forearm blood flow (FBF) could increase forearm glucose uptake (FGU) during hyperinsulinemia.
Positive_regulation (increase) of hyperinsulinemia in forearm associated with hyperinsulinism
4) Confidence 0.03 Published 2003 Journal Metab. Clin. Exp. Section Abstract Doc Link 12701051 Disease Relevance 0.16 Pain Relevance 0.08

General Comments

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