INT109964

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Context Info
Confidence 0.31
First Reported 2003
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.95
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (AKR1B1) carbohydrate metabolic process (AKR1B1) response to stress (AKR1B1)
cytoplasm (AKR1B1) cytosol (AKR1B1) extracellular space (AKR1B1)
AKR1B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
diclofenac 3 96.76 Very High Very High Very High
cINOD 1 96.28 Very High Very High Very High
headache 13 91.24 High High
depression 7 69.24 Quite High
Migraine 77 67.12 Quite High
Opioid 14 54.56 Quite High
withdrawal 2 54.00 Quite High
addiction 2 52.48 Quite High
sSRI 2 49.72 Quite Low
antidepressant 1 47.56 Quite Low
Disease Link Frequency Relevance Heat
Adverse Drug Reaction 211 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 1 97.52 Very High Very High Very High
Headache 68 91.24 High High
Hypoglycemia 1 86.96 High High
Renal Failure 6 75.88 Quite High
Bladder Cancer 1 72.88 Quite High
Toxicity 1 70.48 Quite High
Depression 6 69.24 Quite High
Vomiting 6 64.36 Quite High
Constipation 4 63.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ADR due to digoxin is an example of a pharmacokinetic interaction.
ADR Binding (interaction) of associated with adverse drug reaction
1) Confidence 0.31 Published 2003 Journal Ned Tijdschr Geneeskd Section Abstract Doc Link 12701389 Disease Relevance 0.80 Pain Relevance 0.14
In patient episodes associated with an ADR, the number of medicines taken was significantly higher (median 9, Q1–Q3 6–13) than in those episodes not associated with an ADR (median 6, Q1–Q3 4–10; U?
ADR Neg (not) Binding (associated) of
2) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2635959 Disease Relevance 1.31 Pain Relevance 0.19
In patient episodes associated with an ADR, the number of medicines taken was significantly higher (median 9, Q1–Q3 6–13) than in those episodes not associated with an ADR (median 6, Q1–Q3 4–10; U?
ADR Binding (associated) of
3) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2635959 Disease Relevance 1.06 Pain Relevance 0.03
In a review that analysed studies carried out between 1995 and 2000, the association between ADR of some drugs and the presence of at least one enzyme with a variant allele known to cause poor metabolism has been evidenced.
ADR Spec (analysed) Binding (association) of
4) Confidence 0.08 Published 2007 Journal J Headache Pain Section Body Doc Link PMC2779399 Disease Relevance 0.59 Pain Relevance 0.28
Knowledge about the association of receptor site blockade with a specific ADR, varied from 37% to 76% of respondents.
ADR Binding (association) of
5) Confidence 0.02 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3008836 Disease Relevance 0.19 Pain Relevance 0.07

General Comments

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